Abstract: An antihemophilic factor derived from human blood plasma, having about 1 to 10 units antihemophilic factor activity per mg of protein and being substantially free of denatured antihemophilic factor is prepared from material having 0.3 to 1.0 unit per mg of protein.

Abstract: Purified plasma albumin is obtained by ion exchange chromatographic procedures and in the absence of process steps involving precipitation or desorption of the albumin.

Abstract: Basic zirconium gels may be used to form complexes with conventional aluminum and/or zirconium antiperspirant systems. The freshly prepared basic zirconium gels provide both a buffer for the highly acidic aluminum-zirconium complexes and an additional source of zirconium as an active ingredient in the antiperspirant. The preferred basic zirconium gels are basic zirconium-amino acid compounds, particularly basic zirconium glycinates, and the compounds are preferably added to aluminum-zirconium systems in the form of a wet gel. The preferred basic zirconium glycinate is formed by first reacting sodium carbonate with glycine, and then reacting the resulting sodium glycinate with a zirconium oxy or zirconium hydroxy compound to precipitate out the zirconium basic glycinate gel. Zirconium basic carbonates, prepared by reacting sodium carbonate with a zirconium oxy or hydroxy salt, are useful in preparing antiperspirant complexes with lower basic aluminum chlorides (e.g.

Abstract: The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

Abstract: A method of obtaining suppression of gastric acid secretion in a mammalian host by the oral administration of calcitonin to the host mammal, including man, to obtain the suppression of gastric acid secretion therein. The method is useful in the treatment of mammals having grastric or duodenal ulcers or other conditions which benefit from the suppression of gastric acidity.

Abstract: Basic zirconium gels may be used to form complexes with conventional aluminum and/or zirconium antiperspirant systems. The freshly prepared basic zirconium gels provide both a buffer for the highly acidic aluminum-zirconium complexes and an additional source of zirconium as an active ingredient in the antiperspirant. The preferred basic zirconium gels are basic zirconium-amino acid compounds, particularly basic zirconium-glycinates, and the compounds are preferably added to aluminum-zirconium systems in the form of a wet gel. The preferred basic zirconium glycinate is formed by first reacting sodium carbonate with glycine, and then reacting the resulting sodium glycinate with a zirconium oxy or zirconium hydroxy compound to precipitate out the zirconium basic glycinate gel. The various complexes of the invention may be used in conventional antiperspirant forms, including aqueous solutions, aerosol sprays, powder-in-oil aerosol sprays, creams, lotions, cream sticks, etc.

Abstract: A process and apparatus are provided for making hollow macrospherical particles. The particles themselves are particularly adapted for use as anti-perspirants. The particles have a diameter between about 10 and 74 microns, preferably predominating between 15 and 44 microns, and a greater than unit density. As such, they are not subject to deep lung penetration. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, diffusing the solution through small pores by centrifugal force such that the resulting hollow particles have a diameter greater than the pore diameter, and drying the solution droplets in a stream of heated air. The apparatus for producing the macrospherical particles comprises a centrifugal atomizer having a porous sintered metal filter ring which is rotated inside a spray drying chamber.

Abstract: Improved antiperspirant stick compositions are provided which comprise a substantially anhydrous, homogeneous mixture of an alcohol soluble astringent basic aluminum compound as the active ingredient in a solid or semi-solid system including an alkylene polyhydric alcohol, a normally solid higher fatty acid amide of an alkylolamine in which the fatty acid radical contains at least 12 carbon atoms and the alkylol groups of the alkylolamine contain from 2 to 3 carbon atoms, and a non-toxic dermatologically acceptable non-aqueous solvent, such as ethanol, for the astringent basic aluminum compound. The mixture provides a highly esthestic, stable and quite effective antiperspirant in stick form suitable for application to the human axilla.

Abstract: Peptides having adrenocorticotropic hormone activity and resin peptides useful in preparation of such peptides, particularly such peptides having asparagine at the carboxyl end thereof and more particularly such peptides having from 19 to 25 amino acids in their amino acid chains. The invention further involves new processes for the preparation of such peptides.

Abstract: An automated wet sieving apparatus and process are provided comprising a wetting liquid distributor which is coupled by eccentric disks to a motor which drives the distributor in an orbital path for supplying the liquid onto a sieve. Means are provided for creating alternating vacuum and pressure below the sieve. The vacuum draws undersized particles whose size is being determined through the sieve and the pressure loosens blinding particles from the sieve. Preferably, the sieve is cyclically tilted as the wetting liquid is being distributed onto the sieve.

Abstract: An improvement in freeze-drying of skin tissue for use in treating wounds and diseased areas of the body wherein un-frozen skin is partially dried and frozen by drawing a vacuum across the skin before commencing the freeze-dry process, resulting in a novel product which reconstitutes more rapidly and more completely, and more nearly obtains the properties of fresh skin than obtainable by the product produced by the prior art process. In addition to the advantage of more efficient reconstitution, the method shortens the freeze-dry cycle and is less expensive.

Abstract: Antacid tablets prepared by codrying certain basic aluminum bicarbonate-carbonate compositions with di- or trihydroxy alcohols suitable for oral ingestion, to obtain a powder material, and forming such a material suitably along with tablet forming ingredients into tablets which have superior mouth feel and which yield faster reaction velocities than prior antacid tablets.

Abstract: Antacid compositions prepared by drying a wet, compressed aluminum hydroxide gel to solid form which are capable of being readily resuspended to yield an opaque, aqueous suspension which reflects the properties of the original compressed gel, are produced by codrying a hydrous, gelatinous aluminum hydroxide material with a di- or trihydroxy alcohol.

Abstract: Novel aromatic guanidine compounds having the formula: ##STR1## wherein: R.sub.1 is hydroxyl, methyl or hydroxymethyl and R.sub.2 is hydrogen or methyl, are found to have biological activity. The guanidine compounds and their salts are shown to be active as vasoconstrictor agents and create useful pharmaceutical preparations when deployed with a pharmaceutically acceptable carrier for administration to a host, e.g., man, requiring vasoconstrictive therapy.

Abstract: Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R--CH.sub.2 --O--Phe--Asn at one end of an amino acid chain, R being the resin and Phe and Asn being the residues of the amino acids phenylalanine and asparagine; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological acitivity may be derived.

Abstract: Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure ##STR1## in which R is divinylbenzene crosslinked polystyrene and Bz is benzyl, p-methoxybenzyl, p-chlorobenzyl, p-nitrobenzyl, or benzhydryl, and in which phe and glu are residues of the amino acids phenylalanine and glutamic acid; and processes for preparing such peptide amides.Resin peptide amides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptide amides are disclosed which contain amino acid chains in which the amino acid residues differ in kind or sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

Abstract: A process and apparatus are provided for making hollow macrospherical particles. The particles themselves are particularly adapted for use as anti-perspirants. The particles have a diameter between about 10 and 74 microns, preferably predominating between 15 and 44 microns, and a greater than unit density. As such, they are not subject to deep lung penetration. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, diffusing the solution through small pores by centrifugal force such that the resulting hollow particles have a diameter greater than the pore diameter, and drying the solution droplets in a stream of heated air. The apparatus for producing the macrospherical particles comprises a centrifugal atomizer having a porous sintered metal filter ring which is rotated inside a spray drying chamber.

Abstract: A peptide chosen from the group comprising [Ala.sup.1 ]-HPTH-(1-X) and HPTH-(1-X) wherein X is an integer from 27 to 34.

Abstract: Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the cleaved peptides. In general, the processes involve the solid phase synthesis procedures.

Abstract: Novel aromatic guanidine compounds having the formula: ##STR1## wherein: R.sub.1 is hydroxyl, methyl or hydroxymethyl and R.sub.2 is hydrogen or methyl, are found to have biological activity. The guanidine compounds and their salts are shown to be activate as vasoconstrictor agents and create useful pharmaceutical preparations when deployed with a pharmaceutically acceptable carrier for administration to a host, e.g., man, requiring vasoconstrictive therapy.