Patents Assigned to Associazione Veneta Per La Lotta Alla Talassemia
  • Double-stranded synthetic oligonucleotides useful for inducing apoptosis of osteoclasts for the treatment of osteopenic pathologies
    Patent number: 7659258
    Abstract: The invention relates to a synthetic double-stranded oligonucleotide capable of modifying the molecular phenotype of osteoclasts and increasing the expression of the oestrogen alpha receptor gene. Pharmaceutical compositions comprising the oligonucleotide according to the invention are also described, as well as therapeutic applications of that oligonucleotide, in particular for the treatment of osteopenic diseases such as for example osteoporosis. The oligonucleotide according to the invention is characterized in that it comprises the sequence 5?-ATTTATTTTCAATACTGACT-3? (SEQ ID NO: 1) or a fragment or a mutant thereof.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: February 9, 2010
    Assignees: Universita' Degli Studi di Ferrara, Associazione Veneta per la Lotta Alla Talassemia
    Inventors: Roberto Gambari, Letizia Penolazzi, Roberta Piva
  • Use of angelicin and of its structural analogues for the treatment of thalassemia
    Patent number: 7572827
    Abstract: The use of angelicin and its structural analogues for the preparation of a medicament for the therapeutic treatment of beta-thalassaemia is described. A structural analogue which is particularly preferred for this purpose is bergapten.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: August 11, 2009
    Assignees: Universita' Degli Studi Di Ferrara, Associazione Veneta Per La Lotta Alla Talassemia
    Inventors: Nicoletta Bianchi, Monica Borgatti, Roberto Gambari, Ilaria Lampronti
  • Use of rapamycin and structural analogues thereof
    Patent number: 7541380
    Abstract: The use of rapamycin and its structural analogues for the preparation of a medicament for the therapeutic treatment of beta-thalassaemia is described.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: June 2, 2009
    Assignees: Universita' Degli Studi do Ferrara, Associazione Veneta per la Lotta Alla Talassemia
    Inventors: Nicoletta Bianchi, Monica Borgatti, Roberto Gambari, Carlo Mischiati
  • Double-Stranded Synthetic Oligonucleotides Useful For Inducing Apoptosis of Osteoclasts For the Treatment of Osteopenic Pathologies
    Publication number: 20080171717
    Abstract: The invention relates to a synthetic double-stranded oligonucleotide capable of modifying the molecular phenotype of osteoclasts and increasing the expression of the oestrogen alpha receptor gene. Pharmaceutical compositions comprising the oligonucleotide according to the invention are also described, as well as therapeutic applications of that oligonucleotide, in particular for the treatment of osteopenic diseases such as for example osteoporosis. The oligonucleotide according to the invention is characterised in that it comprises the sequence 5?-ATTTATTTTCAATACTGACT-3? or a fragment or a mutant thereof.
    Type: Application
    Filed: March 30, 2006
    Publication date: July 17, 2008
    Applicants: UNIVERSITA' DEGLI STUDI DI FERRARA, ASSOCIAZIONE VENETA PER LA LOTTA ALLA TALASSEMIA
    Inventors: Roberto Gambari, Letizia Penolazzi, Roberta Piva
  • Heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of ?-thalassaemia
    Patent number: 7396851
    Abstract: The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a medicament for the therapeutic treatment of ?-thalassaemia.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: July 8, 2008
    Assignees: Universita' Degli Studi Di Ferrara, Associazione Veneta per La Lotta Alla Talassemia, Associazione per La Lotta Alla Talassemia Di Ferrara
    Inventors: Pier Giovanni Baraldi, Nicoletta Bianchi, Giordana Feriotto, Roberto Gambari, Carlo Mischiati, Romeo Romagnoli
  • Synthetic oligonucleotides as inducers of erythroid differentiation
    Patent number: 7262175
    Abstract: The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human ?-globin gene; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the ?-globin gene and the ??-cluster, for use as an inducer of erythroid differentiation.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: August 28, 2007
    Assignees: Universita' Degli Studi Di Ferrara, Associazione Veneta Per La Lotta Alla Talassemia, Associazione Per La Lotta Alla Talassemia Di Ferrara, Chiesi Farmaceutici S.p.A.
    Inventors: Nicoletta Bianchi, Giordana Feriotto, Roberto Gambari, Carlo Mischiati
  • Novel Use of rapamycin and structural analogues thereof
    Publication number: 20060154950
    Abstract: The use of rapamycin and its structural analogues for the preparation of a medicament for the therapeutic treatment of beta-thalassaemia is described.
    Type: Application
    Filed: July 3, 2003
    Publication date: July 13, 2006
    Applicants: ITA' DEGLI STUDI DI FERRARA, ASSOCIAZIONE VENETA PER LA LOTTA ALLA TALASSEMIA
    Inventors: Nicoletta Bianchi, Monica Borgatti, Roberto Gambari, Carlo Mischiati