Patents Assigned to Astra Lakemedel Aktiebolag
  • Patent number: 6492352
    Abstract: A method for therapeutic or prophylactic control of Acquired Immunodeficiency Syndrome (AIDS) in which an effective dose of phosphonoformic acid or a therapeutically-acceptable salt thereof is administered to a patent.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: December 10, 2002
    Assignee: Astra Lakemedel Aktiebolag
    Inventor: Bo Fredrik Öberg
  • Patent number: 6476009
    Abstract: The present invention relates to a method of inhibiting the activity of the HIV virus in a human comprising administering to the human an effective dose of phosphonoformic acid or a therapeutically effective salt thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 5, 2002
    Assignee: Astra Lakemedel Aktiebolag
    Inventor: Bo Fredrik Öberg
  • Patent number: 5300660
    Abstract: Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity ##STR1## wherein R.sup.1 is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH.sub.2).sub.m Ph wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group including1) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline2) aminolysis3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R.sup.2 is defined as R.sup.1 above.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: April 5, 1994
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Hans-Jurgen Federsel, Thomas Hogberg, Sten I. Ramsby, Hans E. P. Strom
  • Patent number: 5085868
    Abstract: A dosage form for oral administration of a pharmaceutically active substance characterized in that it includes a encapsulated or embedded pharmaceutically active substance in a pharmaceutically acceptable non-aqueous liquid.
    Type: Grant
    Filed: September 17, 1990
    Date of Patent: February 4, 1992
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Kjell J. Mattsson, Alf G. M. Nicklasson, Rolf Sjoovist
  • Patent number: 4994260
    Abstract: A pharmaceutical mixture with controlled release of actice substance which includes masking of bad taste and stability increasing of active substance characterized in that an encapsulated active substance is combined with a substance controlling the release of active substance from the encapsulation and method for preparing said mixture.
    Type: Grant
    Filed: December 30, 1985
    Date of Patent: February 19, 1991
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Anders G. V. Kallstrand, Kjell J. Mattson, Rolf I. Sjoqvist
  • Patent number: 4956179
    Abstract: An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: September 11, 1990
    Assignees: Astra Lakemedel Aktiebolag, Astra Pharmaceutical Products, Inc.
    Inventors: Peter Bamberg, Bertil A. Ekstrom, Ulf E. Forsgren, Berndt O. H. Sjoberg
  • Patent number: 4898731
    Abstract: An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: February 6, 1990
    Assignees: Astra Lakemedel Aktiebolag, Astra Pharmaceutical Products, Inc.
    Inventors: Peter Bamberg, Bertil A. Ekstrom, Ulf E. Forsgren, Berndt O. H. Sjoberg
  • Patent number: 4889929
    Abstract: Process for the preparation of 1'-ethoxy carbonyloxy ethyl esters of penicillins, wherein a compound of the formula ##STR1## in which A is phenyl, phenoxy or 4-hydroxyphenyl, B is hydrogen, an amino group or a protected amino group and Z is hydrogen or a cation selected from the group of alkali metal, tri (lower alkyl ) ammonium and tetra (lower alkyl) ammonium, is reacted with 1-bromoethyl ethyl carbonate in an organic solvent and when B is a protected amino group the protecting group is split off to yield a primary amino group.There are also provided novel compounds of the formula ##STR2## in which Ph is phenyl and R is CH.sub.3 -- or C.sub.2 H.sub.5 --.
    Type: Grant
    Filed: March 26, 1987
    Date of Patent: December 26, 1989
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Jacob Vaya, David Ladkani, Clara Schoenberger, Joseph Kaspi, Gad Salemnick, Haim Yellin, Stephan Cherkez
  • Patent number: 4870086
    Abstract: Optically pure S-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate, with the structural formula ##STR1## a process for the preparation thereof and the use for inducing local anesthesia.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: September 26, 1989
    Assignee: Astra Lakemedel Aktiebolag
    Inventor: Rune V. Sandberg
  • Patent number: 4820857
    Abstract: The novel compound .alpha.-bromodiethylcarbonate, novel methods for the preparation thereof, its use in the preparation of 1-ethoxycarbonyloxyethyl esters of penicillins and cephalosporins, and improvements in the method for preparing such esters.
    Type: Grant
    Filed: April 13, 1988
    Date of Patent: April 11, 1989
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Derek R. Palmer, Robert G. Tyson
  • Patent number: 4798833
    Abstract: Antivirally active compounds of the formula ##STR1## wherein A is ##STR2## wherein m is 1 or 2,n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1,R.sub.a ' is (CH.sub.2).sub.p OH, NHCONH.sub.2 or COR.sub.a ",R.sub.a " is hydrogen, hydroxy or amino,p is 1 to 4,R.sub.b ' and R.sub.b " are independently selected from hydrogen or (CH.sub.2).sub.p OH,with the proviso that at least one of R.sub.b ' or R.sub.b " is hydrogen; orR.sub.b ' and R.sub.b " together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; pharmaceutical preparations containing the compounds and methods for treatment of virus infections.
    Type: Grant
    Filed: February 6, 1987
    Date of Patent: January 17, 1989
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Karl N. Johansson, Bjorn G. Lindborg, Jan-Olof Noren
  • Patent number: 4789683
    Abstract: Novel therapeutically active compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group or an acyl group, R.sup.3 is a lower alkyl group; an alkenyl group; or a benzyl group optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy, A.sup.1 and A.sup.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, an acyl group, an alkoxycarbonyl group or a dialkylcarbamyl group, provided that when A.sup.1 and A.sup.2 are the same lower alkyl group and R.sup.3 is ethyl, R.sup.1 or R.sup.2 or both are selected among cyano, lower alkyl and acyl; or a physiologically acceptable salt or optical isomers thereof, methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.
    Type: Grant
    Filed: January 8, 1985
    Date of Patent: December 6, 1988
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Gosta L. Florvall, Jan O. G. Lundstrom, Sten I. Ramsby, Sven O. gren
  • Patent number: 4771041
    Abstract: A method for the selective treatment of virus infections in animals and man comprising administering to a host so infected a therapeutically effective amount of phosphonoformic acid or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: September 13, 1988
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Bertil F. H. Eriksson, Ake J. E. Helgstrand, Alfons Misiorny, deceased, Karl H. Misiorny, legal representive, Goran B. Stening, Stig-Ake A. Stridh
  • Patent number: 4665062
    Abstract: A method for the selective treatment of virus infections in animals and man and a method of treating cancer caused by viruses, comprising administering to a host so infected a therapeutically effective amount of phosphonoformic acid or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: May 12, 1987
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Bertil F. H. Eriksson, Ake J. E. Helgstrand, Alfons Misiorny, Goran B. Stening, Stig A. Stridh
  • Patent number: 4656027
    Abstract: The present invention is concerned with masking bad taste in pharmaceutical preparations containing encapsulated drugs with bad taste. The object of the invention is achieved by including a basic substance in the preparation.
    Type: Grant
    Filed: November 2, 1984
    Date of Patent: April 7, 1987
    Assignee: Astra Lakemedel Aktiebolag
    Inventor: Rolf I. Sjoovist
  • Patent number: 4619785
    Abstract: The novel compound .alpha.-bromodiethylcarbonate, its use in the preparation of 1-ethoxycarbonyloxyethyl esters of penicillins and cephalosporins, in particular bacampicillin, and improvements in the method for preparing such esters.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: October 28, 1986
    Assignee: Astra Lakemedel Aktiebolag
    Inventor: Luigi Ratti
  • Patent number: 4612316
    Abstract: Compounds of the formula ##STR1## wherein C.sup.1 and N.sup.4 are in trans configuration to each other, wherein R and Y are defined herein below, as bases and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for treatment of disorders in the central nervous system.
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: September 16, 1986
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Bengt R. Andersson, Folke L. Arvidsson, Per A. E. Carlsson, John S. M. Hjort, Anette M. Johansson, Per L. Lindberg, John L. G. Nilsson, Domingo Sanchez, Kjell A. I. Svensson, Hakan V. Wikstrom
  • Patent number: 4606865
    Abstract: The novel compound .alpha.-bromodiethylcarbonate, novel methods for the preparation thereof, its use in the preparation of 1-ethoxycarbonyloxyethyl esters of penicillins and cephalosporins, and improvements in the method for preparing such esters.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: August 19, 1986
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Derek R. Palmer, Robert G. Tyson
  • Patent number: D288006
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: January 27, 1987
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Nils-Gustaf Bergstrom, Stig B. Lanfelt
  • Patent number: D299168
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: December 27, 1988
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Nils G. Bergstrom, Kenneth Andersson