Patents Assigned to Battelle Pulmonary Therapeutics, Inc.
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Patent number: 6796303Abstract: A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity.Type: GrantFiled: June 3, 2002Date of Patent: September 28, 2004Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: William C. Zimlich, Jr., James E. Dvorsky, David R. Busick, Richard D. Peters
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Patent number: 6705316Abstract: A pulmonary dosing system and method for supplying to a patient a predetermined amount of respirable therapeutically active material is disclosed. The system comprises a patient interface to introduce the material into the patient's lungs and an apparatus for providing pulsed amounts of the material to a plenum chamber. The plenum chamber has a diffuser baffle which increases the efficiency of the dosing system by preventing axial flow of the active material thereby utilizing the available volume of the chamber for holding the aerosolized drug prior to inhalation.Type: GrantFiled: March 11, 2002Date of Patent: March 16, 2004Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: Kevin Sanford Blythe, Anthony Rocco Imondi, Daniel Duane Meek, Andrew O. Ross
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Patent number: 6471943Abstract: A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.Type: GrantFiled: December 30, 1997Date of Patent: October 29, 2002Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: Michael E. Placke, Anthony R. Imondi
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Patent number: 6397838Abstract: A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity.Type: GrantFiled: December 21, 1999Date of Patent: June 4, 2002Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: William C. Zimlich, Jr., James E. Dvorsky, David R. Busick, Richard D. Peters
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Patent number: 6368079Abstract: A piezoelectric micropump is disclosed for pumping fluid from a container to a delivery point in low volumes and at controlled flow rates. The pumping action is created by movement of two or three diaphragms. The movement of each diaphragm is caused by expansion and contraction of an attached piezoelectric actuator. Coordination of the movement of the diaphragms creates unidirectional flow of the fluid. The piezoelectric actuators are cantilevered between the pump body and the diaphragms to provide greater deflection of the diaphragms. The piezoelectric actuators preferably are piezoelectric bimorphs such that the diaphragms can function as both seals and pumps.Type: GrantFiled: December 23, 1998Date of Patent: April 9, 2002Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: Richard D. Peters, Chad E. Bouton, William C. Zimlich, Jr.
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Patent number: 6348209Abstract: A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.Type: GrantFiled: June 6, 2001Date of Patent: February 19, 2002Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: Michael E. Placke, Anthony R. Imondi, Michael J. Brooker, John E. Frye, Praful K. Shah, Douglas R. Flanagan, Jr., Maureen D. Donovan
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Patent number: 6302331Abstract: The invention provides an aerosol delivery method and system for producing a charged electrohydrodynamic (EHD) aerosol, discharging the aerosol and moving the discharged aerosol in a desired direction without substantial wetting of the device. The delivery system may include a spray nozzle for dispensing the fluid to be aerosolized and negatively charging the aerosol droplets, a discharge electrode generally downstream of the spray nozzle for generating a positive ion stream which intercepts and electrically neutralizes the negative aerosol droplets while also imparting a desired movement on the aerosol in a direction generally away from the discharge electrode and a reference electrode between the spray nozzle and the discharge electrode for modifying the electric field between the spray nozzle and the discharge electrode.Type: GrantFiled: April 20, 2000Date of Patent: October 16, 2001Assignee: Battelle Pulmonary Therapeutics, Inc.Inventors: James E. Dvorsky, Songsdhit Chongsiriwatana