Patents Assigned to Bayer HealthCare, LLC
  • Publication number: 20180282430
    Abstract: Antibodies are disclosed that bind to and inhibit the anti-coagulant function of TFPI and have a lower affinity for TFPi at pH 6.0 than at pH 7.4. The lower affinity at pH 6 improves circulating half-life (T1/2) due to reduced target mediated clearance, a process by which an antibody/antigen complex, is endocytased and trafficked to the lysosome where both components are degraded. The lower affinity at pH 6.0 results in disruption of the complex prior to lysosome targeting and allows for re-circulation of the antibody. Specific modifications to antibody binding by histidine residue substitution are disclosed along with methods of use.
    Type: Application
    Filed: April 25, 2018
    Publication date: October 4, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: John E. Murphy, Zhuozhi Wang, Ruth Winter
  • Publication number: 20180263904
    Abstract: The present disclosure relates to chewable gel products containing a gel carrier and an active pharmaceutical ingredient (API), where the chewable gel product has an acceptable taste.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 20, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Rachan SIRIHORACHAI, Reginald D. BRADLEY, Paul D. ROSAR, Anthony EKPE
  • Patent number: 10078725
    Abstract: Provided is a method of collecting and managing information relating to medical diagnostic procedures which includes collecting objective information about a plurality of procedures and subjective information about the results of those procedures. The objective information provides information about the parameters of the procedure and the patient who underwent the procedure while the subjective information includes an assessment of the quality of the results of the procedure. This information can be stored in a database. The database can be accessed and the information therein used in connection with understanding the results of past procedures and planning for future procedures.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: September 18, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John F. Kalafut, David A. Mishler, Sridhar R. Balasubramanian, John A. Brosovich, Frederick P. Windham
  • Publication number: 20180251570
    Abstract: This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.
    Type: Application
    Filed: May 16, 2018
    Publication date: September 6, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Zhuozhi WANG, Ruth WINTER, John MURPHY
  • Patent number: 10060758
    Abstract: A syringe for use with a powered injector to inject a fluid into a patient that includes a length of material adapted to transmit or propagate electromagnetic energy therethrough. The length of material includes at least a first indicator positioned along the length of material. The first indicator is adapted to interact with at least a portion of the energy being propagated through the length of material in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: August 28, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, John A. Brosovich, Alan D. Hirschman, Barry Iddon, Michael J. Yanniello
  • Publication number: 20180240548
    Abstract: A system capable of monitoring a replaceable component is provided. The system includes a controller for controlling operation of the system; programming instructions according to which the system is configured to: accept input of a viable life for the component, calculate an accumulated amount of distress experienced by the component based on each set of previously collected use data associated with each previous use of the component, and determine, based in part on the accumulated amount of distress, a used portion of the viable life that the component has experienced as a result of the previous use(s) thereof and an unused portion of the viable life; and a feedback device configured to provide to an operator of the system an indication of at least one of the unused and used portions of the viable life of the component. Methods of monitoring a replaceable component of a system are also provided.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 23, 2018
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Michael SPOHN, Michael SWANTNER, Edward RHINEHART
  • Patent number: 10046106
    Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: August 14, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Raymond C. Hoffman, Arthur E. Uber, III, Bernard J. Hobi, Vincent S. Rossitto, Jaroslaw Wlodarczyk, Matthew Schrauder
  • Patent number: 10039700
    Abstract: Certain aspects of the invention relate to compositions comprising UV blocking agents, a film forming polymer containing acid groups and a neutralizing agent. Such compositions have an increased SPF due to neutralization of at least a portion of the acid groups of the film forming agent by the neutralizing agent. The invention also discloses methods for increasing SPF of a composition as well as methods for using the novel composition.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: August 7, 2018
    Assignees: Bayer HealthCare LLC, Akzo Nobel Chemicals International B.V.
    Inventors: Qiwei He, Michael Timothy Philbin, Gary Theodore Martino, Thomas A. Meyer, Donathan G. Beasley, John H. Wagner
  • Patent number: 10035840
    Abstract: Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 31, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Richard Feldman, Ji-Yun Kim, Haiyan Jiang, Kirk McLean, Junliang Pan, Glenn Pierce, James Wu, Xiao-Yan Zhao
  • Patent number: 10029220
    Abstract: A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: July 24, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Ralph H. Schriver, Andreas Maihoefer, James A. Dedig, Michael A. Spohn, Herbert M. Grubic, Michael J. Swantner, Adam Caruso
  • Patent number: 10022493
    Abstract: A fluid injection system including an injector head having a syringe for delivering a fluid to a patient, a mounting structure pivotally connected to the injector head and configured to support the injector head above a surface, and a control system operationally coupled to the injector head for controlling an injection procedure is disclosed. The fluid injection system is provided with sensors to control various aspects of the fluid injection system, such as the establishment of a reference plane, the determination of a tilt angle of the injector head, and the determination of a temperature of an actuation system of the injector head.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: July 17, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John D. Shearer, Jr., Christopher M. Scutt, Walter J. Grumski, Michael A. Spohn, Jarrell T. McWilliams, Arlie D. Long, III, Richard C. Morton
  • Patent number: 10016618
    Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 10, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Alan D. Hirschman, Arthur E. Uber, III, David M. Reilly, John F. Kalafut, Frederick W. Trombley, III, Steven J. Remis, Scott Griffith, Douglas Descalzi, Richard Dewit, David M. Griffiths, Marc A. Mabie, Mark Trocki
  • Patent number: D822486
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 10, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Peter Brian Clarke, John Philip Kalinowsky, Ryan Boudreaux, James Troy Starkey, Michael Scott Carpenter, Theresa C. DeSantis, Anna Erixon, Lori King, Robert G. Petit, Martin S. Johnson, Steven Jackan, Eric S. Paszkowski
  • Patent number: D822489
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 10, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: John Bischoff, William A. Bachman, Michael Scott Carpenter, Kimberly McCormack
  • Patent number: D827270
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 4, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent
  • Patent number: D827271
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 4, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent
  • Patent number: D827272
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 4, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent
  • Patent number: D827423
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: September 4, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Carolyn A. DeMaere, Karen O'Boyle, Jason R. Ahleman, Kris M. Linkugel, Sean P. Hafer, John S. Hosa
  • Patent number: D827424
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: September 4, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Carolyn A. DeMaere, Karen O'Boyle, Jason R. Ahleman, Kris M. Linkugel, Sean P. Hafer, John S. Hosa
  • Patent number: D827999
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 11, 2018
    Assignee: Bayer HealthCare LLC
    Inventors: Philip C. Yang, Richard Todd Avent