Patents Assigned to Bayer Schering Pharma Aktiengesellschaft
  • Intermediates for the preparation of lipoxin Aanalogs
    Patent number: 7994346
    Abstract: This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: August 9, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Danja Grossbach, William Guilford, Michael Sander
  • Substituted pyridines, and use thereof as Gsk3 inhibitors
    Publication number: 20110190316
    Abstract: The invention relates to substituted pyridines and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of haematological disorders, preferably of leukopenia and neutropenia.
    Type: Application
    Filed: July 21, 2009
    Publication date: August 4, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Stephan Siegel, Andreas Wilmen, Niels Svenstrup, Mark Jean Gnoth, Adrian Tersteegen, Ulrich Rester
  • ESTRATRIENE DERIVATIVES COMPRISING HETEROCYCLIC BIOISOSTERES FOR THE PHENOLIC A-RING
    Publication number: 20110190246
    Abstract: The present invention is directed to novel pyrazolo-estrien and triazolo-estrien-derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain diseases, cardiovascular diseases, cerebrovascular diseases, hormone sensitive cancers and hyperplasia (in tissues including breast, endometrium, and cervix in women and prostate in men), endometriosis, uterine fibroids, osteoarthritis; and as contraceptive agents either alone or in combination with a progestogen or progestogen antagonist. The compounds of the invention are selective estrogen receptor modulators.
    Type: Application
    Filed: July 14, 2009
    Publication date: August 4, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thorsten Blume, Dieter Heldmann, Norbert Schmees, Christiane Otto, Tim Wintermantel, Joachim Kuhnke
  • SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS
    Publication number: 20110190281
    Abstract: This invention relates to novel sulfone 2I3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 13, 2009
    Publication date: August 4, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Martin Hentemann, William Scott, Jill Wood, Jeffrey Johnson, Aniko Redman, Ann-Marie Bullion, Leatte Guernon
  • 4-Chromenonyl-1,4-dihydropyridines and their use
    Patent number: 7989633
    Abstract: The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: August 2, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Alexander Kuhl, Peter Kolkhof, Heike Heckroth, Karl-Heinz Schlemmer, Ingo Flamme, Santiago Figueroa Perez, Heike Gielen-Haertwig, Rolf Grosser, Jens-Kerim Ergüden, Dieter Lang
  • NOVEL POLYMORPHIC FORMS OF METHYL CARBAMATE
    Publication number: 20110183999
    Abstract: The invention relates to novel forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (I), in particular to the modification I, to processes for their preparation, to medicaments comprising them and to their use for fighting diseases.
    Type: Application
    Filed: November 29, 2010
    Publication date: July 28, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Alfons GRUNENBERG, Franz-Josef MAIS, Winfried JOENTGEN, Birgit KEIL
  • 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof
    Publication number: 20110183928
    Abstract: The present application relates to novel 3-cyanoalkyl- and 3-hydroxyalkyl-substituted indole derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
    Type: Application
    Filed: June 18, 2009
    Publication date: July 28, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Kai Thede, Elisabeth Woltering, Peter Kolkhof, Carsten Schmeck, Elisabeth Pook, Alexander Hillisch, Lars Bärfacker, Klemens Lustig, Dieter Lang, Martin Radtke, Rolf Grosser, Astrid Brüns, Michael Gerisch
  • Substituted dibenzoic acid derivatives and use thereof
    Patent number: 7985876
    Abstract: The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
    Type: Grant
    Filed: March 15, 2008
    Date of Patent: July 26, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Michael Hahn, Eva-Maria Becker, Andreas Knorr, Dirk Schneider, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Dieter Lang
  • 9-ALPHA ESTRATRIENE DERIVATIVES AS ER-BETA SELECTIVE LIGANDS FOR THE PREVENTION AND TREATMENT OF INTESTINAL CANCER
    Publication number: 20110178052
    Abstract: Use of 9?-estra-1,3,5(10)-triene derivatives of formula (I) for the prevention and treatment of intestinal cancer, in particular adenoma and adenocarcinoma of the duodenum, ileum, colon, and rectum.
    Type: Application
    Filed: July 9, 2009
    Publication date: July 21, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Karl-Heinrich Fritzemeier, Patrick Diel, Torsten Hertrampf
  • DIARYL UREA FOR TREATING HEART FAILURE
    Publication number: 20110178137
    Abstract: The present invention relates to pharmaceutical compositions and combinations for treating, preventing or managing heart failure and/or connected diseases therewith comprising 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide optionally combined with at least one additional therapeutic agent.
    Type: Application
    Filed: June 16, 2009
    Publication date: July 21, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Barbara Albrecht-Küpper, Stefan Schäfer, Elodie Kienlen
  • CYLIC POLYAMINES FOR BINDING PHOSPHATIDYLSERINE
    Publication number: 20110177002
    Abstract: The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.
    Type: Application
    Filed: July 14, 2009
    Publication date: July 21, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Sabine Zitzmann-Kolbe, Ulrike Bauder-Wuest, Michael Eisenhut, Doerte Oltmanns
  • ANNELLATED 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20110172221
    Abstract: This invention relates to novel annellated 4-(indazolyl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
    Type: Application
    Filed: May 29, 2009
    Publication date: July 14, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Martin Michels, Markus Follmann, Alexandros Vakalopoulos, Katja Zimmermann, Nicole Teusch, Karen Engel
  • Oxazolidinones for the Treatment of Inflammatory Conditions of the Gastrointestinal Tract
    Publication number: 20110172222
    Abstract: The present invention relates to the use of selective inhibitors of coagulation factor Xa, in particular of oxazolidinones of the formula (I), for the treatment and/or prophylaxis of inflammatory conditions of the gastrointestinal tract such as inflammatory bowel disease (IBD) and celiac disease and/or disorders related to inflammatory bowel disease (IBD) and/or celiac disease such as thromboembolic events (including e.g. pulmonary embolism (PE), arterial and venous thrombosis, myocardial infarction, stroke) as well their use for the preparation of pharmaceutical drugs for the treatment and/or prophylaxis of inflammatory bowel disease (IBD) and/or celiac disease and/or disorders related to inflammatory bowel disease (IBD) and/or celiac disease such as thromboembolic events.
    Type: Application
    Filed: June 23, 2009
    Publication date: July 14, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Georges Von Degenfeld, Elisabeth Perzborn, Wolfgang Thielemann, Susanne Röhrig, Fiona McDonald
  • AMINOACYL PRODRUGS AS AN ACTIVE PHARMACEUTICAL INGREDIENT FOR THROMBOEMBOLIC DISORDERS
    Publication number: 20110172232
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Application
    Filed: June 28, 2008
    Publication date: July 14, 2011
    Applicant: Bayers Schering Pharma Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Michael Härter, Mark Jean Gnoth, Georges Von Degenfeld, Elke Dittrich-Wengenroth, Anja Buchmüller, Susanne Röhrig, Swen Allerheiligen, Elisabeth Perzborn, Christoph Gerdes, Karl-Heinz Schlemmer, Metin Akbaba
  • SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF
    Publication number: 20110166163
    Abstract: The present application relates to novel substituted furopyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
    Type: Application
    Filed: June 3, 2008
    Publication date: July 7, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Thomas Lampe, Raimund Kast, Mario Jeske, Friederike Stoll, Joachim Schuhmacher, Eva-Maria Becker, Hartmut Beck
  • NOVEL [F-18]- LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), USE THEREOF AND METHOD FOR THEIR PRODUCTION
    Publication number: 20110165076
    Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
    Type: Application
    Filed: May 14, 2009
    Publication date: July 7, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Ludger Dinkelborg, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Detlev Sülzle, Norman Koglin
  • Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments
    Publication number: 20110166168
    Abstract: The present invention relates to sulphone-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.
    Type: Application
    Filed: July 18, 2009
    Publication date: July 7, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Bernd Buchmann, Dirk Kosemund, Duy Nguyen, Arne Von Bonin
  • SOLUTIONS FOR PERFUSING AND PRESERVING ORGANS AND TISSUES
    Publication number: 20110159474
    Abstract: The present invention relates to solutions which are suitable for the perfusion and preservation of organs, organ parts, tissues or tissue parts of human or animal origin. The solutions suitable for this contain at least one active agent, which is selected from the group of NO-independent stimulators and activators of soluble guanylate cyclase. The invention furthermore relates to methods for producing the solutions according to the invention, and to the use of the solutions in various types of medical procedures, particularly in the field of transplantation medicine.
    Type: Application
    Filed: May 24, 2008
    Publication date: June 30, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Johannes-Peter Stasch, Reiner Frey
  • DETERMINATION OF FREE FRACTIONS
    Publication number: 20110143363
    Abstract: The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmacologically active compounds in aqueous solutions and serum. The invention also relates to the above methods in which solid particles, coated with a lipophilic medium, are used.
    Type: Application
    Filed: June 14, 2010
    Publication date: June 16, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Joachim SCHUHMACHER, Christian Kohlsdorfer
  • Polynucleotides encoding anticoagulant antibodies
    Patent number: 7960532
    Abstract: This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, an inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: June 14, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: David Light, Kirk McLean