Patents Assigned to Baylor College of Medicine
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Patent number: 11826315Abstract: Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.Type: GrantFiled: April 18, 2019Date of Patent: November 28, 2023Assignees: Tvardi Therapeutics, Baylor College of MedicineInventors: Sofia De Achaval, David John Tweardy
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Patent number: 11819483Abstract: Embodiments of the disclosure include certain formulations for methods of treating urea cycle disorders. The methods encompass compositions that comprise benzoate and phenylbutyrate that may be at certain doses and have certain ratios of the components. The benzoate and phenylbutyrate may act synergistically in treatment of the urea cycle disorders, in particular embodiments.Type: GrantFiled: November 16, 2022Date of Patent: November 21, 2023Assignee: Baylor College of MedicineInventors: Juan C. Marini, Sandesh Chakravarthy Sreenath Nagamani
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Patent number: 11821002Abstract: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.Type: GrantFiled: March 7, 2022Date of Patent: November 21, 2023Assignees: Baylor College of Medicine, Wilson Wolf ManufacturingInventors: Juan F. Vera, Cliona M. Rooney, Ann M. Leen, John R. Wilson
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Patent number: 11814687Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.Type: GrantFiled: August 7, 2020Date of Patent: November 14, 2023Assignees: The Broad Institute, Inc., The General Hospital Corporation, Baylor College of Medicine, The Brigham and Women's Hospital, Inc., Northwestern University, The Johns Hopkins University, United States Government as represented by the U.S. Department of Veterans AffairsInventors: Jaegil Kim, Gad Getz, Seth Paul Lerner, David Kwiatkowski, Joshua Meeks, Joaquim Bellmunt, David McConkey
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Publication number: 20230357200Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.Type: ApplicationFiled: June 5, 2023Publication date: November 9, 2023Applicant: BAYLOR COLLEGE OF MEDICINEInventors: Bert W. O'Malley, David Michael Lonard, Yongcheng Song
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Publication number: 20230346765Abstract: Provided herein are methods of using niflumic acid and derivatives thereof for treating a disease or condition associated with elevated serum uric levels in a subject. The methods include administering to the subject an effective amount of a pharmaceutical composition as described herein. The disease or condition associated with elevated serum uric levels can include, for example, gout, hyperuricemia, or cardiovascular disease. Also provided herein are methods of reducing serum uric acid levels in a subject and methods for inhibiting xanthine oxidase activity in a cell. Novel pharmaceutical compositions are also provided herein.Type: ApplicationFiled: March 3, 2021Publication date: November 2, 2023Applicant: Baylor College of MedicineInventors: Changyi Chen, Qizhi Yao, Jian-Ming Lu
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Publication number: 20230337643Abstract: The present disclosure provides a chimeric non-human animal comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to screening and identifying metabolites for any type of drugs, typically small molecule drugs, which might affect human liver functions and any other bodily function.Type: ApplicationFiled: June 15, 2023Publication date: October 26, 2023Applicant: Baylor College of MedicineInventors: Karl-Dimiter BISSIG, Maria DE LAS MERCEDES BARZI DIEGUEZ, Francis Peter PANKOWICZ
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Patent number: 11793543Abstract: An automatic insertion device and method of using the same is provided. A vibrator and an extender are connected to a penetrating member and are both in electrical communication with a controller. A detector identifies a subcutaneous target for insertion and the insertion angle, distance and trajectory for the penetrating member are calculated. The vibrator provides vibrations to the penetrating member and the extender advances the penetrating member for insertion. The vibrator and extender are in electrical communication with one another during the insertion process and adjustments to the insertion speed are made based on feedback of vibrational load encountered by the vibrator during insertion, and adjustments to the vibrations are made based on feedback of insertion load encountered by the extender during insertion. Iterative samples are taken to constantly adjust the operation of one motor based on the operations and feedback from the other motor.Type: GrantFiled: April 1, 2020Date of Patent: October 24, 2023Assignees: Obvius Robotics, Inc., Baylor College of MedicineInventors: Roger B. Bagwell, Ryan S. Clement, Maureen L. Mulvihill, Casey A. Scruggs, Kevin A. Snook, William E. Cohn, James Patrick Herlihy, Kenneth Wayne Rennicks
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Patent number: 11786494Abstract: A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a salt thereof, for example phenylbutyrate or an even numbered congener thereof or a salt thereof, is administered to an individual in need thereof. In various methods, a decrease in plasma levels of branched chain amino acids and branched chain alpha-keto acids is effected to treat individuals suffering from an inborn error in metabolism of amino acids, such as Maple Syrup Urine Disease, for example.Type: GrantFiled: January 10, 2020Date of Patent: October 17, 2023Assignee: Baylor College of MedicineInventor: Brendan Lee
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Publication number: 20230324411Abstract: Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.Type: ApplicationFiled: February 1, 2023Publication date: October 12, 2023Applicants: Texas Children's Hospital, Baylor College of MedicineInventors: Parag Parekh, Ananth Annapragada
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Patent number: 11781178Abstract: Provided herein are compositions and methods for the synthesis, amplification, and in vitro transcription of full-length cDNA, or cDNA fragments. Methods are provided for reverse transcription of RNA and amplification for in vitro transcription. Further provided are method for loading of dendritic cells with the RNA and homologous lysate for immune stimulation.Type: GrantFiled: December 17, 2018Date of Patent: October 10, 2023Assignee: Baylor College of MedicineInventors: William K. Decker, Vanaja Konduri
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Patent number: 11751759Abstract: One aspect of the invention provides a trocar including: a central cylinder defining a central channel and having a distal end adapted and configured for insertion within a subject; one or more gas outlets located within the central cylinder proximate to the distal end of the trocar; and one or more liquid outlets located within the central cylinder on a proximal side of the one or more gas outlets. The one or more liquid outlets are adapted and configured to dispense a liquid when an endoscope is withdrawn from a fully extended position within the central channel of the trocar to a position proximate to the one or more liquid outlets. Distal advancement of the endoscope to a position adjacent to the one or more gas outlets removes liquid from a distal end of the endoscope.Type: GrantFiled: April 13, 2017Date of Patent: September 12, 2023Assignees: Baylor College of Medicine, Texas Heart InstituteInventors: Bryan M. Burt, Mahmood Khan, William Cohn
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Patent number: 11746359Abstract: The present invention relates to gene therapy delivery and expression systems comprising at least one helper-dependent adenoviral vector containing a nucleic acid sequence encoding for proteoglycan 4 (PRG4) or a biologically active fragment thereof. The invention further relates to a pharmaceutical composition comprising a therapeutically effective amount of at least one helper-dependent adenoviral vector containing said nucleic acid sequence encoding for proteoglycan 4 (PRG4), or a homolog thereof from any other species, or a biologically active fragment thereof. The invention also relates to the use of the novel gene therapy delivery and expression system according to the invention for use in the prevention and/or treatment of camptodactyly-arthropathy-coxa vara-pericarditis (CACP), or a musculoskeletal disorder such as a joint disorder or joint disease.Type: GrantFiled: April 1, 2022Date of Patent: September 5, 2023Assignee: Baylor College of MedicineInventors: Merry Ruan, Kilian Guse, Brendan Lee
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Patent number: 11730711Abstract: Compositions and methods are related to utilizing glycine and N-acetylcysteine for a variety of medical conditions related to reduced levels of glycine, N-acetylcysteine, and/or glutathione, for example, muscle loss such as sarcopenia, HIV infection and other infections, organ damage such as those from diabetes and insulin resistance and diabetic nephropathy, cardiac function and failure such as preventing or improving heart failure, fatty liver, cancer prevention, and other conditions.Type: GrantFiled: February 12, 2021Date of Patent: August 22, 2023Assignees: Baylor College of Medicine, Societe de Produits Nestle S.A.Inventors: Stephen Kirnon, Eric Freedland, Rajagopal V. Sekhar
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Publication number: 20230255606Abstract: Improved nasopharyngeal swabs for COVID-19 or other molecular diagnostic testing are discussed herein. Swab designs for adult use are not suitable for pediatric use. Swabs for pediatric use need to be smaller and more flexible to navigate delicate pediatric nasopharyngeal cavities. A novel use of maxillofacial CT scans to aid in the design of pediatric nasopharyngeal swabs satisfying such criteria is discussed. Further, the novel swabs are also suitable for 3D printing.Type: ApplicationFiled: July 21, 2021Publication date: August 17, 2023Applicants: BAYLOR COLLEGE OF MEDICINE, TEXAS CHILDREN’S HOSPITALInventors: Zbigniew Starosolski, Prasad Admane, James Dunn, Brent Kaziny, Ananth Annapragada
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Patent number: 11725061Abstract: Embodiments of the disclosure include methods and compositions related to chimeric antigen receptors (CAR) that target chondroitin sulfate proteoglycan-4 (CSPG4). T cells transduced with a CSPG4-specific CAR are effective for inhibition of particular cancer cells that express CSPG4. In certain embodiments, the cancer is melanoma, breast cancer, head and neck cancer, mesothelioma, glioblastoma, or renal cancer.Type: GrantFiled: April 27, 2018Date of Patent: August 15, 2023Assignees: The General Hospital Corporation, Baylor College of MedicineInventors: Gianpietro Dotti, Soldano Ferrone
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Patent number: 11717538Abstract: The present invention concerns compositions and methods related to approaches to render ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. In particular embodiments, tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulaotyr/activating signal. In specific embodiments, the T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.Type: GrantFiled: January 15, 2020Date of Patent: August 8, 2023Assignee: Baylor College of MedicineInventors: Ann Marie Leen, Juan F. Vera
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Patent number: 11716974Abstract: The present disclosure provides a chimeric non-human animal comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to screening and identifying metabolites for any type of drugs, typically small molecule drugs, which might affect human liver functions and any other bodily function.Type: GrantFiled: June 27, 2017Date of Patent: August 8, 2023Assignee: Baylor College of MedicineInventors: Karl-Dimiter Bissig, Maria de las Mercedes Barzi Dieguez, Peter Francis Pankowicz
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Publication number: 20230240923Abstract: One aspect of the invention provides a self-contained patient-bed-and-headboard assembly including: a patient bed and a headboard. The patient bed includes: a central region; a head region hingedly attached to the central region; and a foot region hingedly attached to the foot region. Both the head region and the foot region can rotate between: a first position in which the head region and the foot region are substantially upright; and a second position in which the head region and the foot region are coplanar. Both the head region and the foot region each comprise one or more lateral attachment points. The headboard includes one or more complementary attachments points adapted and configured to engage with the one or more lateral attachment points of the head region and the foot region of the patient bed when in the first position.Type: ApplicationFiled: August 30, 2021Publication date: August 3, 2023Applicant: Baylor College of MedicineInventor: Sharmila Anandasabapathy
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Patent number: 11712559Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.Type: GrantFiled: May 14, 2021Date of Patent: August 1, 2023Assignees: William Marsh Rice University, Texas Heart Institute, Baylor College of MedicineInventors: Yuxiang Sun, Aydin Babakhani, Mehdi Razavi, David Burkland, Brian Greet, Mathews John, Hongming Lyu