Patents Assigned to Baylor College of Medicine
  • Publication number: 20210128755
    Abstract: Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.
    Type: Application
    Filed: July 7, 2020
    Publication date: May 6, 2021
    Applicants: Alzeca Biosciences, LLC, Texas Children's Hospital, Baylor College of Medicine
    Inventors: Ananth Annapragada, Qingshan Mu, Carlo Medici
  • Publication number: 20210115017
    Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.
    Type: Application
    Filed: September 24, 2020
    Publication date: April 22, 2021
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Bert W. O'Malley, David Michael Lonard, Yongcheng Song
  • Publication number: 20210106622
    Abstract: The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Applicant: Baylor College of Medicine
    Inventors: Leonid S. METELITSA, Daofeng Liu, Gianpietro Dotti, Andras Heczey
  • Patent number: 10973812
    Abstract: A method for treating a subject having, or at risk of having, ataxia, generally includes administering to the subject an amount of a composition comprising a cholecystokinin receptor (Cck1R) agonist effective to ameliorate at least one symptom or clinical sign of ataxia.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: April 13, 2021
    Assignees: Regents of the University of Minnesota, Baylor College of Medicine
    Inventors: Harry T. Orr, Emily A. L. Wozniak, Huda Y. Zoghbi
  • Publication number: 20210093864
    Abstract: One aspect of the invention provides a computer-implemented method of conveying a visual image to a blind subject fitted with a visual prosthesis. The computer-implemented method includes: mapping a representation of a visual image onto a two-dimensional array of points having a resolution greater than or equal to an electrode resolution of the visual prosthesis; identifying one or more continuous paths along the mapped representation; and controlling the visual prosthesis to sequentially actuate electrodes along the one or more paths. Another aspect of the invention provides a system including: a visual prosthesis comprising multiple electrodes; and an imaging processing device in communication with the visual prosthesis. The imaging processing device can be programmed to receive an image and perform any of the methods described herein.
    Type: Application
    Filed: March 5, 2019
    Publication date: April 1, 2021
    Applicant: Baylor College of Medicine
    Inventors: Michael S. Beauchamp, Daniel Yoshor, William H. Bosking, III
  • Publication number: 20210085209
    Abstract: One aspect provides a method of treating a swallowing, mastication, or speech articulation disorder associated with a CNS lesion, PNS lesion, or lesioned brain region in a patient. The method includes: measuring a magnitude and a spatial extent of activation in a plurality of brain regions of the patient during movement of the tongue by functional magnetic resonance imaging (fMRI); generating a map of an individualized network of brain regions that control tongue movement; identifying at least one intact brain region functionally associated with the lesioned brain region based on the map of the individualized network of brain regions; tracking at least one tongue movement of the patient; providing neuronal feedback to the patient based on a level of activation of the at least one intact brain region identified and the at least one tongue movement; and instructing the patient to change at least one motor behavior of the tongue.
    Type: Application
    Filed: February 8, 2019
    Publication date: March 25, 2021
    Applicant: Baylor College of Medicine
    Inventors: Theodora Dorina Papageorgiou, Emmanouil Froudarakis
  • Patent number: 10952982
    Abstract: The present invention concerns compositions and methods related to utilizing glycine and N-acetylcysteine for a variety of medical conditions (e.g., muscle loss such as sarcopenia, HIV infection and others, organ damage such as those from diabetes and insulin resistance and diabetic nephropathy, cardiac function and failure such as preventing or improving heart failure, fatty liver, cancer prevention, and others) related to reduced levels of glycine, N-acetylcysteine, and/or glutathione.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: March 23, 2021
    Assignees: Societe des Produits Nestle S.A., Baylor College of Medicine
    Inventors: Stephen Kirnon, Eric Freedland, Rajagopal V. Sekhar
  • Publication number: 20210077612
    Abstract: Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.
    Type: Application
    Filed: January 31, 2019
    Publication date: March 18, 2021
    Applicant: Baylor College of Medicine
    Inventors: Carlos A. Ramos, Cliona M. Rooney, Sandhya Sharma, Benjamin Flyun Joon Shin, Alex Salyer
  • Patent number: 10921327
    Abstract: Embodiments of the present disclosure pertain to methods of detecting a thiol in an environment by exposing the environment to a probe molecule that contains a marker and a thiol responsive group. The thiol responsive group reversibly reacts with the thiol in the environment to form a probe-thiol adduct. This in turn causes a ratiometric change in a spectrometric property of the probe molecule and the probe-thiol adduct, which can then be correlated to the presence of the thiol in the environment. The correlation can occur by quantifying the thiol concentration in the environment. In addition, thiol detection can occur in real-time. Further embodiments of the present disclosure pertain to probe molecules that are utilized for detecting a thiol in an environment. In some embodiments, the probe molecule includes a marker and a thiol responsive group. In some embodiments, the probe molecule also includes an organelle targeting moiety.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: February 16, 2021
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Jin Wang, Xiqian Jiang, Jianwei Chen
  • Patent number: 10898699
    Abstract: One aspect of the invention provides a vaginal stent system including: an inflatable vaginal stent and a removable handle. The inflatable vaginal stent include includes: an elastomeric exterior wall and a first fitting located at a base of the inflatable vaginal stent. The removable handle is adapted and configured for insertion, inflation, and removal of the inflatable vaginal stent from a subject's vagina. The removable handle includes a second fitting complementary to the first fitting and adapted and configure to form substantially fluid tight coupling when the handle is coupled to the inflatable vaginal stent. Another aspect of the invention provides a method of fabricating a customized vaginal stent or dilator. The method includes: generating a 3D model of a vaginal stent or dilator; and controlling a 3D printer to fabricate a vaginal stent or dilator according to the 3D model.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: January 26, 2021
    Assignee: Baylor College of Medicine
    Inventors: Julie Hakim, Jennifer Elizabeth Dietrich, Peter Alexander Smith, Cara Buskmiller
  • Patent number: 10888830
    Abstract: Provided herein are biomolecular hybridization devices comprising a substrate with a permanently and covalently attached surface of functional groups and an adsorbed monolayer of unmodified, single-stranded oligonucleotides all of which are 10 to about 24 bases in length as a saturated film of constrained oligonucleotides on the surface via direct non-covalent phosphate-surface adsorptive contact of substantially all phosphate groups of each oligonucleotide. The constrained oligonucleotides are effective to dissociably hybridize to a complementary single-stranded nucleic acid with asymmetric, non-helical base pairing and without oligonucleotide dissociation from the surface of the device. Also, provided are methods for hybridizing solution-state target nucleic acids to probe nucleic acids and for identifying a nucleotide sequence to which a nucleotide-binding protein binds using the biomolecular hybridization devices.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: January 12, 2021
    Assignees: Genomics USA, Inc., Baylor College of Medicine
    Inventors: Michael E. Hogan, Joseph G. Utermohlen, Frederick H. Eggers, Krishna Jayaraman
  • Patent number: 10886005
    Abstract: A method and computer system for identifying genes associated with a phenotype includes obtaining data representing mutations in a cohort of subjects exhibiting a phenotype. An evolutionary action (EA) score is calculated for each mutation using the data obtained. For each gene in the cohort, respective distributions of the calculated EA scores are determined for mutations found in the gene. The determined distributions of EA scores are quantitatively compared within the cohort and with random distributions to establish comparison data. Based on the comparison data, distributions of EA scores are identified that are non-random, and linkage of each gene in the cohort to the phenotype is assessed based on the identified non-random distributions to identify genes associated with the phenotype. The phenotype can be a disease, such as cancer, and linkage of each gene in the cohort to the disease can be assessed to identify disease causing genes.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: January 5, 2021
    Assignee: Baylor College of Medicine
    Inventors: Olivier Lichtarge, Teng-Kuei Hsu, Panagiotis Katsonis, Amanda Michele Koire
  • Patent number: 10875841
    Abstract: Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: December 29, 2020
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Bert W. O'Malley, David Michael Lonard, Yongcheng Song
  • Publication number: 20200375447
    Abstract: Force sensing may be integrated with a laryngoscope and information conveyed to the user when an applied force in a patient's mouth may cause dental trauma. By warning the user, the user may be interrupted before dental trauma occurs, allowing the user to adjust the procedure.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 3, 2020
    Applicant: Baylor College of Medicine
    Inventors: Kevin Rody Kotamarti, Aaron Kotamarti
  • Publication number: 20200370133
    Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 26, 2020
    Applicants: The Broad Institute, Inc., The General Hospital Corporation, Baylor College of Medicine, The Brigham and Women?s Hospital, Inc., Northwestern University, The Johns Hopkins University, United States Government as represented by the U.S. Department of Veterans Affairs
    Inventors: Jaegil Kim, Gad Getz, Seth Paul Lerner, David Kwiatkowski, Joshua Meeks, Joaquim Bellmunt, David McConkey
  • Patent number: 10842814
    Abstract: Methods and compositions are provided for inhibiting, preventing, ameliorating and/or reducing damage to DNA in non-cancerous cells in a subject undergoing chemotherapeutic treatment and/or radiation treatment of cancer cells in the subject, comprising administering to the subject one or more compounds of arsenic in a therapeutically effective amount prior to chemotherapeutic treatment and/or radiation treatment.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: November 24, 2020
    Assignees: Board of Regents of the University of Texas System, Baylor College of Medicine
    Inventors: Chul Soo Ha, Zhi-Min Yuan, Hang Su, Edward Paul Hasty, Alison A. Bertuch, Maria Monica Gramatges, Gregory P. Swanson
  • Publication number: 20200323932
    Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 15, 2020
    Applicant: Baylor College of Medicine
    Inventors: Masataka Suzuki, Amanda Rosewell Shaw, Caroline Elaine Porter, Norihiro Watanabe, Malcolm K. Brenner
  • Patent number: 10799333
    Abstract: A magnet assisted surgical device, system, and method employs magnetic sections, catheters, and guidewires to modify tubular stentgrafts in-situ. One example application provides a more reliable way for surgeons to modify stentgrafts insitu to allow blood flow to continue to branching blood vessels that would otherwise be blocked by the stentgraft itself. One such method includes placing a tip section of the device in the desired location, deploying a stentgraft, placing a magnetic device inside the stentgraft, connecting the magnetic device to the tip section, and excising the portion of the stentgraft held between the magnet and the tip section.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: October 13, 2020
    Assignees: Baylor College of Medicine, Texas Heart Institute
    Inventors: Ramyar Gilani, Ourania Preventza, William E. Cohn
  • Patent number: 10786549
    Abstract: Embodiments of the disclosure include methods and compositions related to immunotherapy that targets CD5. In particular embodiments, immune cells engineered to comprise a chimeric antigen receptor (CAR) that targets CD5 are contemplated, and uses thereof. In particular embodiments, the immune cells expressing the CAR do not commit fratricide to any great extent against T cells that express CD5 and which are endogenous to an individual receiving the immune cells.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: September 29, 2020
    Assignee: Baylor College of Medicine
    Inventors: Maksim Mamonkin, Malcolm K. Brenner
  • Patent number: 10772914
    Abstract: Methods for generating/expanding populations of immune cells comprising immune cells specific for an Epstein Barr Virus (EBV) lytic antigen are disclosed, the methods comprising stimulating immune cells specific for an EBV lytic antigen by contacting peripheral blood mononuclear cells (PBMCs) with: (i) one or more peptides corresponding to all or part of one or more EBV lytic antigens; or (ii) antigen presenting cells (APCs) presenting one or more peptides corresponding to all or part of one or more EBV lytic antigens. Also disclosed are populations of immune cells comprising immune cells specific for an EBV lytic antigen expanded according to such methods, and uses thereof.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: September 15, 2020
    Assignee: Baylor College of Medicine
    Inventors: Cliona M. Rooney, Sandhya Sharma