Patents Assigned to Baylor College of Medicine
  • Publication number: 20180222931
    Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.
    Type: Application
    Filed: August 16, 2017
    Publication date: August 9, 2018
    Applicants: Board of Regents, The University of Texas System, Baylor College of Medicine
    Inventors: John S. McMURRAY, Pijus Kumar MANDAL, Pietro MORLACCHI, Morgan KNIGHT, David B. CORRY
  • Patent number: 10024856
    Abstract: Embodiments of the disclosure include methods and/or compositions for the detection of viral infection, including at least Norovirus infection. In particular embodiments, there are methods and/or compositions employing particular peptides and/or phage useful for detecting Norovirus in a sample. The sample may be from an environment or from an individual. The individual may be a mammal, including a human, cow, horse, dog, cat, pig, and so forth. Certain exemplary peptides and phage that express the peptides are identified as useful for binding to Norovirus. Such peptides and phage are provided to one or more samples in order to identify whether or not Norovirus is present in the sample.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: July 17, 2018
    Assignee: Baylor College of Medicine
    Inventors: Timothy Gerald Palzkill, Mary K. Estes, Robert Legare Atmar, Jennifer Dawn Rogers, Nadim Jose Ajami
  • Patent number: 10019912
    Abstract: A hearing device may provide hearing-to-touch sensory substitution as a therapeutic approach to deafness. Through use of signal processing on received signals, the hearing device may provide better accuracy with the hearing-to-touch sensory substitution by extending beyond the simple filtering of an incoming audio stream as found in previous tactile hearing aids. The signal processing may include low bitrate audio compression algorithms, such as linear predictive coding, mathematical transforms, such as Fourier transforms, and/or wavelet algorithms. The processed signals may activate tactile interface devices that provide touch sensation to a user. For example, the tactile interface devices may be vibrating devices attached to a vest, which is worn by the user. The vest may also provide other types of information to the user.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: July 10, 2018
    Assignees: Baylor College of Medicine, William Marsh Rice University
    Inventors: David M. Eagleman, Scott Novich
  • Patent number: 9981010
    Abstract: A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: May 29, 2018
    Assignees: Baylor College of Medicine, William Marsh Rice University
    Inventors: Alan R. Davis, Elizabeth A. Davis, Kevin Moran, Ronke M. Olabisi, Jennifer L. West, Christy Franco
  • Patent number: 9976122
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: May 22, 2018
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: David Spencer, Priyadharshini Narayanan
  • Patent number: 9963677
    Abstract: The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: May 8, 2018
    Assignees: Baylor College of Medicine, Wilson Wolf Manufacturing
    Inventors: Ann M. Leen, Ulrike Gerdemann, Cliona M. Rooney, Juan Vera, John R. Wilson
  • Patent number: 9956319
    Abstract: The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on the surface of a medical device or subject's body.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: May 1, 2018
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Mohammad David Mansouri, Rabih O. Darouiche
  • Patent number: 9943608
    Abstract: In some embodiments, the present disclosure pertains to compositions for nucleic acid delivery into cells. In some embodiments, the composition comprises: (1) a cationic polymer unit comprising a plurality of polymeric arms, where the plurality of polymeric arms comprise poly(aspartic acid) derivatives; and (2) a nucleic acid associated with the cationic polymer unit. In some embodiments, the cationic polymer unit comprises a linker covalently associated with the plurality of polymeric arms. In some embodiments, the cationic polymer unit has a dendritic shape. In some embodiments, the cationic polymer unit has a star-like shape. In some embodiments, the cationic polymer unit is biodegradable. Further embodiments of the present disclosure pertain to methods of delivering a nucleic acid into cells by introducing into the cells one or more of the compositions of the present disclosure.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: April 17, 2018
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Jin Wang, Fude Feng
  • Publication number: 20180071502
    Abstract: One aspect of the invention provides a vaginal stent system including: an inflatable vaginal stent and a removable handle. The inflatable vaginal stent include includes: an elastomeric exterior wall and a first fitting located at a base of the inflatable vaginal stent. The removable handle is adapted and configured for insertion, inflation, and removal of the inflatable vaginal stent from a subject's vagina. The removable handle includes a second fitting complementary to the first fitting and adapted and configure to form substantially fluid tight coupling when the handle is coupled to the inflatable vaginal stent. Another aspect of the invention provides a method of fabricating a customized vaginal stent or dilator. The method includes: generating a 3D model of a vaginal stent or dilator; and controlling a 3D printer to fabricate a vaginal stent or dilator according to the 3D model.
    Type: Application
    Filed: April 4, 2016
    Publication date: March 15, 2018
    Applicant: Baylor College of Medicine
    Inventors: Julie HAKIM, Jennifer Elizabeth DIETRICH, Peter Alexander SMITH, Cara BUSKMILLER
  • Patent number: 9913887
    Abstract: The present invention encompasses methods and compositions for Ureaplasma infection prevention and/or treatment. In specific cases, the invention concerns vaccines for Ureaplasma, including DNA vaccines. In certain embodiments, the invention regards vaccines directed towards the multiple-banded antigen(s) of Ureaplasma.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: March 13, 2018
    Assignee: Baylor College of Medicine
    Inventors: Leonard Weisman, Lingkun Kong
  • Publication number: 20180044673
    Abstract: Disclosed herein are methods for decreasing MECP2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate MECP2 associated disorders and syndromes. Such MECP2 associated disorders include MECP2 duplication syndrome.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Applicants: Ionis Pharmaceuticals, Inc., Baylor College of Medicine
    Inventors: Huda Y. Zoghbi, Ezequiel Sztainberg, Susan M. Freier
  • Publication number: 20180002371
    Abstract: Bufalin phosphate prodrugs are provided herein, as well as methods for their use as small molecule inhibitors of steroid receptor coactivator (SRC) family proteins. Methods for using bufalin phosphate prodrugs in treating or preventing cancer are also provided herein.
    Type: Application
    Filed: December 29, 2015
    Publication date: January 4, 2018
    Applicant: Baylor College of Medicine
    Inventors: Jin WANG, Jianming XU, David Michael LONARD, Bert W. O'MALLEY, Timothy Gerald PALZKILL
  • Publication number: 20170360581
    Abstract: One aspect of the invention provides a prosthetic foot including a heel member, a toe member, and an attachment member comprising a shear thickening material (STM). In one embodiment, the attachment member has a first end and a second end. The first end can be connected to the heel member, and the second end can be connected to the toe member. In another embodiment, the attachment member further comprises an elastic polymer. In one instance, the elastic polymer is impregnated with the STM. In yet another embodiment, the attachment member further comprises an elastic reservoir. The elastic reservoir can contain the STM. Alternatively, the attachment member further comprises a rigid reservoir. The rigid reservoir can contain the STM.
    Type: Application
    Filed: November 30, 2015
    Publication date: December 21, 2017
    Applicant: Baylor College of Medicine
    Inventors: Jared Howell, Lorin Merkley
  • Publication number: 20170333267
    Abstract: One aspect of the invention provides a mobile clinic including: an intermodal container defining at least a first opening and a second opening; a partition wall located within the intermodal container, the partition wall separating the intermodal container into an anteroom and a treatment room; and an access control device programmed to prevent passage from the anteroom into the treatment room until a user's donning of personal protective equipment is verified. Another aspect of the invention provides a collapsible structure including: a rigid base; a rigid roof; one or more collapsible walls extending between the floor and the base; and an erector system comprising four cross-bars. Another aspect of the invention provides a crate including: a bottom panel; a top panel; and a plurality of walls, wherein at least two of said plurality of wails including one or more conduits.
    Type: Application
    Filed: November 11, 2015
    Publication date: November 23, 2017
    Applicant: Baylor College of Medicine
    Inventors: Sharmila Anandasabapathy, Sarah Michel, Caroline Popper
  • Publication number: 20170325934
    Abstract: A magnet assisted surgical device, system, and method employs magnetic sections, catheters, and guidewires to modify tubular stentgrafts in-situ. One example application provides a more reliable way for surgeons to modify stentgrafts insitu to allow blood flow to continue to branching blood vessels that would otherwise be blocked by the stentgraft itself. One such method includes placing a tip section of the device in the desired location, deploying a stentgraft, placing a magnetic device inside the stentgraft, connecting the magnetic device to the tip section, and excising the portion of the stentgraft held between the magnet and the tip section.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 16, 2017
    Applicants: Baylor College of Medicine, Texas Heart Institute
    Inventors: Ramyar Gilani, Ourania Preventza, William E. Cohn
  • Patent number: 9810966
    Abstract: Optical scanning system, comprising an optical system for guiding a first and a second light beam, and deflector devices for deflecting first and second light beams in a directionally variable manner. The deflector devices comprise at least one acousto-optic deflector, and the optical system is arranged in such a way that the first and second light beams are counter-propagating through the acousto-optic deflector, which is controllable for deflecting the first and second light beams simultaneously or in pulse sequence. STED microscopy apparatus comprising an optical scanning system based on acousto-optic deflectors.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: November 7, 2017
    Assignees: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, BAYLOR COLLEGE OF MEDICINE
    Inventors: Paolo Bianchini, Peter Saggau, Alberto Diaspro
  • Patent number: 9789120
    Abstract: The invention relates to compositions and methods for effecting male contraception.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: October 17, 2017
    Assignees: Dana-Farber Cancer Institute, Inc., Baylor College of Medicine
    Inventors: James Elliott Bradner, Martin Matzuk, Jun Qi
  • Publication number: 20170290830
    Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 12, 2017
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Bert W. O'Malley, David Michael Lonard, Jin Wang, Jianming Xu, Jianwei Chen
  • Patent number: 9765099
    Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 19, 2017
    Assignees: Board of Regents, The University of Texas System, Baylor College of Medicine
    Inventors: John S. McMurray, Pijus Kumar Mandal, Pietro Morlacchi, Morgan Knight, David B. Corry
  • Patent number: 9758785
    Abstract: The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including sensitization to cancer therapy or prevention of a cancer to become sensitized to a cancer therapy. In specific embodiments, the microRNAs include miR-520a (including at least miR-520a-3p and miR-520-5p), miR-520g, miR-520h, and functional variants thereof. In some embodiments, the cancer is ovarian cancer, and in particular embodiments, the cancer therapy is platinum-based chemotherapy.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: September 12, 2017
    Assignees: Baylor College of Medicine, University of Houston
    Inventors: Matthew L. Anderson, Claire Mach, Preethi Gunaratne