Patents Assigned to Ben-Gurion University of the Negev Research and Development Authority
  • Patent number: 9844336
    Abstract: An embodiment of the invention provides a method of diagnosing obstructive sleep apnea, the method comprising: acquiring a sleep sound signal comprising sounds made by a person during sleep; detecting a plurality of snore sounds in the sleep sound signal; determining a set of mel-frequency cepstral coefficients for each of the snore sounds; determining a characterizing feature for the sleep sound signal responsive to a sum of the variances of the cepstral coefficients; and using the characterizing feature to diagnose obstructive sleep apnea in the person.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: December 19, 2017
    Assignees: Ben Gurion University of the Negev Research and Development Authority, Mor Research Applications Ltd.
    Inventors: Yaniv Zigel, Ariel Tarasiuk, Nir Ben Israel
  • Publication number: 20170328895
    Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.
    Type: Application
    Filed: August 3, 2017
    Publication date: November 16, 2017
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Hanna RAPAPORT, Anna GITTELMAN
  • Patent number: 9802989
    Abstract: An isolated novel oil globule protein encoded by a polynucleotide sequence is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which at least partially comprises the amino acid sequence of the novel oil globule protein is also provided. The invention also provides a method for producing or enhancing the production of a carotenoid such as astaxanthin, which is an oil globule constituent.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: October 31, 2017
    Assignees: Ben Gurion University of the Negev Research and Development Authority, Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Sammy Boussiba, Ehud Peled, Uri Pick, Aliza Zarka, Stefan Lou, Meira Weiss
  • Patent number: 9731046
    Abstract: The present invention provides a multi-compartment hydrogel, and a sulfated polysaccharide and at least two bioactive polypeptides capable of binding said sulfated polysaccharide, for use in repair or regeneration of a damaged tissue in a mammal. Also provided is a method for constructing the multi-compartment hydrogel. The present invention also provides a method for the repair or regeneration of a damaged tissue in a mammal, and a kit for constructing a multi-compartment hydrogel.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: August 15, 2017
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Smadar Cohen, Tali Re'Em, Emil Ruvinov
  • Patent number: 9731048
    Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: August 15, 2017
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Hanna Rapaport, Anna Gittelman
  • Patent number: 9721691
    Abstract: The present invention provides a method for producing molybdenum-99 comprising: i) providing an electron accelerator; ii) providing a molybdenum converter/target unit (Mo-CTU) comprising one or more metallic components, wherein each one of said metallic components is made of a material selected from the group consisting of natural molybdenum, molybdenum-100, molybdenum-98, and mixtures thereof; iii) directing an electron beam generated via said electron accelerator onto said Mo-CTU to produce a braking radiation (bremsstrahlung); iv) employing said bremsstrahlung onto said Mo-CTU to produce molybdenum-99 and neutrons via a photo-neutron reaction; v) slowing down the neutrons produced in step iv) with a low atomic liquid, e.g. distilled water; and optionally vi) employing the neutrons produced in step iv) to produce a complementary amount of molybdenum-99 via a neutron capture reaction on said Mo-CTU. The invention further provides an apparatus for producing molybdenum-99.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: August 1, 2017
    Assignee: Ben-Gurion University of the Negev, Research and Development Authority
    Inventor: Alexander Tsechanski
  • Patent number: 9718849
    Abstract: Sulfur chelated ruthenium compounds represented by the following formula: wherein M indicates the ruthenium metal bound to a benzylidene carbon; R represents C1-C7 alkyl group or optionally substituted aryl; X1 and X2 each independently represent halogen; Y1 and Y2 each independently denote unsubstituted or alkyl-substituted phenyl; and Z independently represents hydrogen, electron withdrawing or electron donating substituent, with m being an integer from 1 to 4, and processes and compositions related thereto.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: August 1, 2017
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: N. Gabriel Lemcoff, Amos Ben-Asuly
  • Patent number: 9711253
    Abstract: A radiotherapy system is disclosed. The radiotherapy system comprises an electron beam generator for generating an electron beam and a magnetic field generator for generating a magnetic field. In some embodiments of the present invention, the system further comprises a controller for controlling the electron beam and the magnetic field generators such that the electron beam is dynamically shifted and the magnetic field is dynamically redirected synchronously with the shifting.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: July 18, 2017
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Dror Alezra, Eran Nardi, Sion Koren, Itzhak Orion
  • Patent number: 9670139
    Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: June 6, 2017
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Aviv Gazit, Shimon Slavin, Esther Priel, Sara Yitzchak
  • Patent number: 9670249
    Abstract: The present invention relates in general to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: June 6, 2017
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Hanna Rapaport
  • Patent number: 9670138
    Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: June 6, 2017
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventor: Esther Priel
  • Patent number: 9663448
    Abstract: The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 30, 2017
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Esther Priel, Aviv Gazit, Shimon Slavin, Sara Yitzchak
  • Patent number: 9649598
    Abstract: The invention provides a process for purifying water containing soluble species capable of forming one or more sparingly soluble salts or minerals, said process comprising feeding a pressurized water stream into a treatment zone having one or more membranes disposed therein, passing said stream along said membrane(s) to recover a permeate and to withdraw a concentrate therefrom while periodically reversing the direction of the flow of said stream in said treatment zone, wherein the periodicity of the flow reversal is such that said one or more membranes are exposed to supersaturation conditions evolving in said water stream for a period of time which is less then the time required for said supersaturated water stream to precipitate one or more of said sparingly soluble salts and/or minerals therefrom.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: May 16, 2017
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Jack Gilron, Eliyahu Korin
  • Patent number: 9642803
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 9, 2017
    Assignee: Ben-Gurion University Of The Negev Research And Development Authority
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Patent number: 9597001
    Abstract: This invention provides a fully automatic method and a system for detecting and classifying cardiac arrhythmias from a surface ECG record. The method defines four relevant parameters whose values are extracted from said ECG record. Clinically relevant conclusions are assigned to various combinations of the obtained values of said parameters. The method can be employed for detecting fetal QRS complexes from abdomen ECG of a pregnant woman.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: March 21, 2017
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventors: Yaniv Zigel, Amos Katz, Or Perlman, Nahum Noam Weisman
  • Patent number: 9594346
    Abstract: A method of generating a hologram of an object is disclosed. The method comprises: receiving data corresponding to a plurality of non-coherent sub-holograms acquired by an optically passive synthetic aperture holographic apparatus, combining the sub-holograms to generate a mosaic hologram of the object, and transmitting the mosaic hologram to a computer readable medium.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 14, 2017
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Joseph Rosen, Barak Katz
  • Patent number: 9518926
    Abstract: The invention is a surface plasmon resonance (SPR) sensor to determine the presence and quantity of biological or chemical entities in an analyte. The sensor comprises a metal periodic structure deposited as a thin layer of a noble metal, comprising a one dimensional array of nanoslits or a two dimensional array of nanoholes on a transparent dielectric substrate, a nm-thick layer of transparent dielectric protection layer on top of the metal periodic structure and a functionalization layer, which acts as a binding layer to biological or biochemical entities in an analyte that is in contact with the functionaliztion layer.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: December 13, 2016
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventor: Ibrahim Abdulhalim
  • Publication number: 20160317558
    Abstract: Conjugates of drugs suitable for use in the treatment of inflammatory bowel disease and phospholipids, and their use in the treatment of inflammatory bowel disease, are disclosed. The disclosed conjugates serve as targeted prodrugs which are suitable for oral administration, and which are capable of releasing the drug selectively at the diseased tissue upon activation by PLA2.
    Type: Application
    Filed: July 11, 2016
    Publication date: November 3, 2016
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Arik DAHAN
  • Publication number: 20160317570
    Abstract: The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.
    Type: Application
    Filed: July 10, 2016
    Publication date: November 3, 2016
    Applicants: Hadasit Medical Research Services and Development Ltd., Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Yaron ILAN, Gadi LALAZAR, Eyal SHTEYER, Ami BEN-YA'ACOV, Smadar COHEN, Tsiona ELKAYAM
  • Patent number: 9458438
    Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel sulfotransferase is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which is at least partially encoded by a novel sulfotransferase is also provided. The invention also includes a process for in-vivo and in-vitro making a sulfated polysaccharide from an unsulfated polysaccharide or increasing the sulfur content of an already sulfated polysaccharide.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: October 4, 2016
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Shoshana Arad, Lena Plesser, Yaakov Weinstein