Patents Assigned to Ben-Gurion University of the Negev Research and Development Authority
  • Patent number: 9458438
    Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel sulfotransferase is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which is at least partially encoded by a novel sulfotransferase is also provided. The invention also includes a process for in-vivo and in-vitro making a sulfated polysaccharide from an unsulfated polysaccharide or increasing the sulfur content of an already sulfated polysaccharide.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: October 4, 2016
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Shoshana Arad, Lena Plesser, Yaakov Weinstein
  • Patent number: 9457056
    Abstract: The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporetic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporetic medications and inducing bone repair.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: October 4, 2016
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Hanna Rapaport
  • Patent number: 9443630
    Abstract: Systems and methods for coherent splitting of a matter wave for supporting a variety of applications and fundamental studies in the fields of matter wave momentum splitting and interferometry. The systems and methods utilize pulsed field gradients and Rabi transitions between internal energy states. A matter wave is transformed into a superposition of spatially separated propagating wavepackets and spatial interference fringes with measurable phase repeatability were measured as a proof for the coherence of the splitting. A continuously tunable wide range of momentum difference between wavepackets may be received by controlling only the duration and strength of the pulsed gradients. Achieving high phase stability and various splitting schemes using different geometries, fields and energy levels, as well as various interferometric applications are disclosed.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: September 13, 2016
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Ron Folman, Yonathan Japha, Shimon Machluf
  • Patent number: 9434959
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: September 6, 2016
    Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Leslie Lobel, Guy Gubi
  • Patent number: 9410132
    Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel acyl-CoA: diacylglycerol acyltransferase 1-like gene (PtDGAT1) from the diatom Phaeodactylum tricomutum is provided together with a composition which includes the isolated protein and a transgenic organism transformed by a polynucleotide encoding same. The invention also provides a method for producing or enhancing the production of oil or triacylglycerols with high saturated fatty acids content.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: August 9, 2016
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Freddy Guiheneuf, Stefan Leu, Aliza Zarka, Inna Khozin-Goldberg, Sammy Boussiba
  • Patent number: 9413528
    Abstract: The invention is a method for broadcast encryption that allows a broadcaster to send encrypted data to a set of users such that only a subset of authorized users can decrypt said data. The method comprises modifications to the four stages of the basic Cipher-text Policy Attribute-Based Encryption techniques. The method can be adapted to transform any Attribute-Based Encryption scheme that supports only temporary revocation into a scheme that supports the permanent revocation of users.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: August 9, 2016
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Shlomi Dolev, Niv Gilboa, Marina Kopeetsky
  • Patent number: 9387222
    Abstract: The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.
    Type: Grant
    Filed: November 27, 2008
    Date of Patent: July 12, 2016
    Assignees: Hadasit Medical Research Services and Development Ltd., Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Yaron Ilan, Gadi Lalazar, Eyal Shteyer, Ami Ben-Yaakov, Smadar Cohen, Tsiona Elkayam
  • Patent number: 9345753
    Abstract: Compositions and methods for prevention and treatment of Alzheimer's disease utilize a combination of amyloid-beta protein or a fragment thereof and a heat shock protein or a fragment thereof.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: May 24, 2016
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Alon Monsonego, Irun R. Cohen
  • Patent number: 9315837
    Abstract: Isolated proteins which are at least partially encoded by polynucleotide sequences encoding novel desaturases are provided together with a composition which includes these isolated proteins. A transgenic plant, a transgenic alga, or a transgenic seed transformed by the polynucleotides encoding proteins which are at least partially encoded by novel desaturases are also provided. The invention also includes a process for making a very long-chain polyunsaturated fatty acid in a transformed cell, a transgenic alga, or a transgenic plant expressing the isolated protein or proteins which are at least partially encoded by the polynucleotide sequences encoding novel ?5, ?6, or ?12 desaturases.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: April 19, 2016
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Iskandarov Umidjon, Inna Khozin Goldberg, Zvi Hacohen
  • Patent number: 9310186
    Abstract: The invention is a system and method for obtaining interference and optical coherence tomography images from an object. The system comprises a wideband source, an optical mask for extending the depth of field, a a liquid crystal tunable filter and a phase modulator all of which are uniquely integrated in a Linnik interferometer microscope. The system has several imaging modes: in the time domain mode the device may operate either with wideband illumination or with quasi monochromatic illumination. The monochromatic illumination can be varied in wavelength along a wide spectral region thus allowing true spectroscopic imaging in high resolution and with high speed. Due to the liquid crystal tunable filter and the optical mask, the frequency domain mode is also accessible. The method of obtaining the optical coherence tomography images, both in the time and in the frequency domains, using the liquid crystal retarder is described in detail.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: April 12, 2016
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Ibrahim Abdulhalim, Avner Safrani
  • Patent number: 9294190
    Abstract: System and method for compensating distortions introduced by an optical channel and by at least one directly modulated transmitting laser that transmits a modulated optical signal that carries data to a receiving end over the optical channel.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: March 22, 2016
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV, RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Dan Sodot, Nir Sheffi
  • Patent number: 9288045
    Abstract: A method for providing spectral and temporal stealthy information transmitted over an optical communication channel, according to which, at the transmitting side, the power spectral density of a pulse sequence bearing the information is reduced by encrypting the temporal phase of the pulse sequence. The power of the pulse sequence is spread in the frequency domain, to be below the noise level, by sampling the pulse sequence. Spectral phase encoding is used to temporally spread the pulse sequence and to prevent coherent addition of its spectral replicas in frequency domain. The resulting signal, encrypted both in time and frequency domains, is then transmitted. Spectral phase decoding is performed at the receiving side by performing coherent detection and folding all the spectral replicas of the transmitted signal to the baseband by means of sampling. The temporal phase of the signal is decrypted and the information which is delivered by the pulse sequence is decoded.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: March 15, 2016
    Assignees: Ben-Gurion University of the Negev Research and Development Authority, Bar-Ilan University
    Inventors: Dan Sadot, Zeev Zalevsky, Tomer Yeminy
  • Patent number: 9267129
    Abstract: The present invention provides a protein, specifically Parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism. In particular, the present invention discloses a mutated acetohydroxyacid synthase which is resistant to herbicides.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: February 23, 2016
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Omer Grundman, Inna Khozin-Goldberg, Zvi Hacohen, Michal Shapira, Dina Raveh, Sammy Boussiba, Boris Zorin
  • Publication number: 20150377989
    Abstract: An optical magnetometer comprising: a response frequency measurement unit comprising a vapor cell, a pulsed-mode pump laser and a probe laser; and a computing unit configured to compute a magnetic field change based on a difference between at least two temporally-distinct response frequency values received from the frequency measurement unit. Optionally, the response frequency measurement unit is magnetically non-shielded.
    Type: Application
    Filed: February 3, 2014
    Publication date: December 31, 2015
    Applicant: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Andrei Ben Amar Baranga, David Levron, Eugene Paperno, Reuben Shuker
  • Publication number: 20150366903
    Abstract: The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.
    Type: Application
    Filed: August 28, 2015
    Publication date: December 24, 2015
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Amir SAGI, Amir BERMAN, Yosef BEN
  • Publication number: 20150359931
    Abstract: This invention is directed to coral scaffolds seeded with precursor cells in culture in the presence of a chelator and uses thereof in inducing or enhancing bone and/or cartilage formation in a subject, and kits related thereto. This invention is also directed to use of cadherin-upregulating coral for treating cancer or inhibiting cancer progression. This invention is also directed to use of aragonite or calcite-producing species for in vivo calcium release, and its application to the treatment of skin diseases, disorders or conditions.
    Type: Application
    Filed: January 8, 2015
    Publication date: December 17, 2015
    Applicant: Ben Gurion University of the Negev Research and Development Authority.
    Inventor: Razi VAGO
  • Patent number: 9175053
    Abstract: The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: November 3, 2015
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Ashraf Brik, Mahmood Haj-Yahya, Ajish Kumar, Leslie Erlich, Liat Spasser
  • Publication number: 20150299805
    Abstract: This invention is directed, inter alia, to methods and kits for rapid, easy and cost-effective methods of breast cancer prediction and diagnosis in inter alia, blood samples.
    Type: Application
    Filed: January 9, 2015
    Publication date: October 22, 2015
    Applicants: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY, MOR RESEARCH APPLICATIONS LTD.
    Inventor: Amos Douvdevani
  • Patent number: 9164062
    Abstract: A method of early detection of scaling on internal surfaces of conduits of water processing equipment, is provided herein. The method includes: transmitting ultrasonic signals through the wall of the conduits; deriving data samples from received ultrasonic signals or reflections thereof; calculating a moving average of the scatter of the ultrasonic signals, over time, based on the data samples; applying a statistical operand to the moving average, to yield a statistical distribution metric; determining a dynamic window defined by: (i) an upper boundary being the moving average plus at least a fraction of the statistical distribution metric and (ii) a lower boundary being the moving average minus the at least a fraction of the statistical distribution metric; generating a trend line being a smooth fitting of the derived samples; and monitoring the trend line within the window to detect a crossover of the trend line at either of the boundaries.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: October 20, 2015
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Alan R Greenberg, Jack Gilron, Keith D Cobry, Elmira Kujundzic, Xiao Yun Lu, Guy Mizrahi, Michael Peterson
  • Patent number: 9149494
    Abstract: The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.
    Type: Grant
    Filed: November 24, 2006
    Date of Patent: October 6, 2015
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Amir Sagi, Amir Berman, Yosef Ben