Abstract: Compositions, methods, and kits including extracts containing physalins and pure physalins are provided for inducing neurogenesis in cells and tissues. The extracts for example are obtained from natural sources such as a plant, for example Physalis angulata. The extracts and purified physalins increase proliferation of neural stem cells, differentiation of the neural progenitor cells in areas of the brain, for example the hippocampus, and are effective for treating neurodegenerative disorders, neurological disease, and neurological conditions.