Patents Assigned to BIODURO, LLC
  • Patent number: 10836717
    Abstract: Disclosed herein are compounds of formula Ar—N(SO2F)2, wherein Ar is selected from an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl. Also disclosed are methods of synthesizing the above compounds by reacting a compound of formula Ar—NH—R9 with MN(SO2F)2.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: November 17, 2020
    Assignees: BioDuro, LLC, Pfizer Inc.
    Inventors: Hua Zhou, Paramita Mukherjee, Rongqiang Liu, Christopher W. Am Ende, Tianjing Deng
  • Publication number: 20190388395
    Abstract: Disclosed herein are processes for formulating a protein or a peptide for oral delivery, the process comprising the steps of: obtaining a powder containing the protein or peptide; obtaining an amount of an enteric polymer, wherein the enteric polymer is neutralized so that it is soluble in water; optionally obtaining at least one excipient; mixing the protein or peptide, the neutralized enteric polymer, and optionally the at least one excipient to obtain a First Dispersion; granulating the First Dispersion on a fluidized bed to obtain a Second Dispersion; whereby the protein or peptide in the Second Dispersion undergoes less than 50% proteolysis under gastric conditions.
    Type: Application
    Filed: August 6, 2019
    Publication date: December 26, 2019
    Applicant: BIODURO, LLC
    Inventors: James Blair WEST, Ke SHI
  • Publication number: 20190047950
    Abstract: Disclosed herein are compounds of formula Ar—N(SO2F)2, wherein Ar is selected from an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl. Also disclosed are methods of synthesizing the above compounds by reacting a compound of formula Ar—NH—R9 with MN(SO2F)2.
    Type: Application
    Filed: August 14, 2018
    Publication date: February 14, 2019
    Applicants: BIODURO, LLC, PFIZER INC.
    Inventors: Hua ZHOU, Paramita MUKHERJEE, Rongqiang LIU, Christopher W. AM ENDE, Tianjing DENG
  • Publication number: 20190030003
    Abstract: Disclosed herein are processes for formulating a protein or a peptide for oral delivery, the process comprising the steps of: obtaining a powder containing the protein or peptide; obtaining an amount of an enteric polymer, wherein the enteric polymer is neutralized so that it is soluble in water; optionally obtaining at least one excipient; mixing the protein or peptide, the neutralized enteric polymer, and optionally the at least one excipient to obtain a First Dispersion; granulating the First Dispersion on a fluidized bed to obtain a Second Dispersion; whereby the protein or peptide in the Second Dispersion undergoes less than 50% proteolysis under gastric conditions.
    Type: Application
    Filed: March 21, 2018
    Publication date: January 31, 2019
    Applicant: BIODURO, LLC
    Inventors: James Blair WEST, Ke SHI