Patents Assigned to Biologix, Inc.
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Publication number: 20220305061Abstract: A method for making an acellular human amnion-derived composition configured for therapeutic use is disclosed and generally includes the steps: obtaining amniotic membrane tissue; testing the amniotic membrane tissue for pathogens; washing the amniotic membrane tissue; manually removing blood-containing chorion tissue from the amniotic membrane tissue decellularizing the amniotic membrane tissue with xeno-free enzymes; collecting amniotic cells from the decellularized amniotic membrane tissue; seeding the amniotic cells for culture into xeno-free media formulated for mesenchymal stem cells; growing the amniotic cells to a specified confluency; collecting conditioned media; and freezing the collected conditioned media; wherein the method further includes irradiating the conditioned media.Type: ApplicationFiled: June 16, 2022Publication date: September 29, 2022Applicant: AXOLOTL BIOLOGIX, INC.Inventors: Robert S. Kellar, Robert B. Diller, Robert G. Audet, Eric T. Lee, Andrew T. Vo
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Publication number: 20220152119Abstract: A method for making an acellular human amnion-derived composition configured for therapeutic use is disclosed and generally includes the steps: obtaining amniotic membrane tissue; testing the amniotic membrane tissue for pathogens; washing the amniotic membrane tissue; manually removing blood-containing chorion tissue from the amniotic membrane tissue decellularizing the amniotic membrane tissue with xeno-free enzymes; collecting amniotic cells from the decellularized amniotic membrane tissue; seeding the amniotic cells for culture into xeno-free media formulated for mesenchymal stem cells; growing the amniotic cells to a specified confluency; collecting conditioned media; and freezing the collected conditioned media; wherein the method further includes irradiating the conditioned media.Type: ApplicationFiled: August 10, 2020Publication date: May 19, 2022Applicant: AXOLOTL BIOLOGIX, INC.Inventors: Robert S. Kellar, Robert B. Diller, Robert G. Audet, Eric T. Lee, Andrew T. Vo
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Publication number: 20220133807Abstract: Methods of treating alopecia, connective tissue disease, or chronic skin wounds in a subject by administration of a therapeutically effective amount of a novel acellular human amnion-derived composition are disclosed. The novel acellular human amnion-derived composition is generally characterized as containing: one or more tissue-remodeling biomolecules, one or more proliferation biomolecules, one or more angiogenic biomolecules, one or more migration biomolecules, one or more anti-inflammatory biomolecules, and one or more anti-microbial biomolecules. Moreover, the acellular human amnion-derived composition is sterilized under conditions that preserve biological functionality and efficacy. Other features and characteristics of the treatment methods and compositions are described.Type: ApplicationFiled: January 7, 2022Publication date: May 5, 2022Applicant: AXOLOTL BIOLOGIX, INC.Inventors: Robert G. Audet, Robert S. Kellar
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Patent number: 11191780Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.Type: GrantFiled: April 29, 2016Date of Patent: December 7, 2021Assignee: Adaptive Biologix, Inc.Inventors: Gail K. Naughton, Frank Zeigler, Emmett Pinney
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Patent number: 10675303Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.Type: GrantFiled: November 30, 2018Date of Patent: June 9, 2020Assignee: Adaptive Biologix, Inc.Inventors: Gail K. Naughton, Emmett Pinney
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Publication number: 20100055093Abstract: Provided are pan-cell surface receptor-specific therapeutics, methods for preparing them and methods of treatment using them. Among the pan-cell surface receptor-specific therapeutics are pan-HER-specific therapeutics that interact with at least two different HER receptor ligands and/or dimerize with or interact with two or more HER cell surface receptors. By virtue of these properties, the therapeutics modulate the activity of at least two cell surface receptors and are useful for therapeutic purposes.Type: ApplicationFiled: June 12, 2007Publication date: March 4, 2010Applicant: RECEPTOR BIOLOGIX INC.Inventors: H. Michael Shepard, Pei Jin, Louis E. Burton, Malgorzata Beryt
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Publication number: 20080113426Abstract: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.Type: ApplicationFiled: May 26, 2005Publication date: May 15, 2008Applicant: MILLENIUM BIOLOGIX INCInventors: Timothy J.N. Smith, Sydney M. Pugh, Lowell Misener, Guy Oram, Rupert Hagg, Roberto Tommasini, Yves Larcher
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Publication number: 20070161081Abstract: Isoforms of ligands, including isoforms of hepatocyte growth factor (HGF) containing an intron-encoded portion, and pharmaceutical compositions containing HGF isoforms are provided. The HGF ligand isoforms and compositions containing them can be used in methods of treatment of diseases, such as cancer and other angiogenic diseases.Type: ApplicationFiled: October 31, 2006Publication date: July 12, 2007Applicant: Receptor Biologix, Inc.Inventors: Pei Jin, H. Shepard, Irene Ni
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Patent number: 7235376Abstract: The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided. The method provides a precise assay for the amounts of free and total G17 and G34 in biological fluid samples, as well as the amounts of free and total Gly-extended G17, and Gly-extended G34. Also provided are methods of determining suitable treatment for patient suffering from a gastrin hormone-mediated disease or condition employing gastrin hormone immunoassays.Type: GrantFiled: March 29, 2004Date of Patent: June 26, 2007Assignee: Receptor Biologix, Inc.Inventors: Stephen Grimes, John Little, Lorraine McLoughlin
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Publication number: 20060141623Abstract: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.Type: ApplicationFiled: April 8, 2003Publication date: June 29, 2006Applicant: Millenium Biologix, Inc.Inventors: Timothy Smith, M Sydney, Hagg Rupert, Tommasini Roberto, Larcher Yves, D Kowell
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Publication number: 20050288229Abstract: Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG”and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.Type: ApplicationFiled: May 2, 2003Publication date: December 29, 2005Applicant: Millenium Biologix Inc.Inventors: Dennis Sindrey, Sydney Pugh, Timothy Smith
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Patent number: 6846493Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 ?. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: GrantFiled: May 10, 2002Date of Patent: January 25, 2005Assignee: Millenium Biologix Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah Dorthea Langstaff
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Patent number: 6585992Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: GrantFiled: October 4, 2001Date of Patent: July 1, 2003Assignee: Millenium Biologix, Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah Dorthea Langstaff
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Publication number: 20020042657Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: ApplicationFiled: October 4, 2001Publication date: April 11, 2002Applicant: Millenium Biologix, Inc.Inventors: Sydney M. Pugh, Timothy J.N. Smith, Michael Sayer, Sarah Dorthea Langstaff
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Patent number: 6361312Abstract: The invention is directed to an automated materials processing furnace capable of high temperature operation. The furnace is moveable and enables sample insertion into either end and includes a stationary sample affixed to a replaceable tray. The furnace enables the processing of material samples under both terrestrial and microgravity conditions and also provides for the monitoring of process parameters.Type: GrantFiled: June 28, 2000Date of Patent: March 26, 2002Assignee: Millenium Biologix IncInventors: Sydney M. Pugh, Timothy J. N. Smith, D. Lowell Misener, Reginald W. Smith
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Patent number: 6323146Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.Type: GrantFiled: March 19, 1998Date of Patent: November 27, 2001Assignee: Millenium Biologix, Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah Dorthea Langstaff
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Patent number: 5861306Abstract: The present invention describes a multi-well bone cell culture device for use in the quantitative and/or qualitative assessment of bone cell activity, the device comprising a flat base having a sintered film of calcium phosphate entities on one side and an open-ended multi chamber unit positioned on top of the film which by a sealing means is sealed to the film coated base forming individual containment wells. The device is useful in the analysis of bone cell function, for the screening and determination of bone cell disease, and the development of drugs to alter bone cell activity.Type: GrantFiled: April 28, 1997Date of Patent: January 19, 1999Assignee: Millenium Biologix, Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith
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Patent number: 5849569Abstract: A calcium phosphate based thin film on which bone cells may be cultured to permit evaluation of bone cell functional properties comprises calcium phosphate entities which provide for varying degrees of resorption of the calcium phosphate entities in evaluating the functional properties. The film is sufficiently thin that resorption of the entities can be detected. Such film, as applied to a support, is a very useful analytical component for evaluating such bone cell functional characteristics. An analytical device, which may be used in an analytical kit, can be provided having a plurality of wells with the devices located at the bottom thereof. A process is provided for making the film and especially the film which has a combination of calcium hydroxyapatite with tricalcium phosphate.Type: GrantFiled: July 12, 1995Date of Patent: December 15, 1998Assignee: Millenium Biologix, Inc.Inventor: John E. Davies
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Patent number: 5766669Abstract: An improved process for producing a thin film of calcium phosphate entities to support bone cell activity thereon. The material to be sintered is prepared by combining a solution of ammonium phosphate with a solution of calcium nitrate to form a sol-gel containing hydroxyapatite. A film of the sol gel is applied to at least one side of the substrate and the film coated on the substrate is sintered to form a solid film of calcium phosphate entities. The improvement in the process comprising sintering the film at temperatures selected from a range of temperatures which optimize a composition of calcium phosphate entities in the film. The sintering step converts hydroxyapatite to .alpha.-tricalcium phosphate where extent of such conversion is temperature dependent. The optimized composition comprises a ratio of hydroxyapatite to .alpha.-tricalcium phosphate in the range of 50:50 to 20:80. A sintering temperature is selected to provide these ratios. The sintering temperature is selected from a range of 920.Type: GrantFiled: October 30, 1997Date of Patent: June 16, 1998Assignee: Millenium Biologix Inc.Inventors: Sydney M. Pugh, Timothy J. N. Smith
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Patent number: 4940945Abstract: An interface circuit for use in a portable apparatus for measuring the electrochemical characteristics of a sample is disclosed. A disposable cartridge, including a plurality of interconnected flow chambers, houses a printed circuit board substrate upon which reference and indicating electrodes are formed. The electrodes are employed in the presence of chemical reagents to aid in the electrochemical determination of a sample undergoing analysis. Such a system provides a high source impedance signal. Interface circuitry is provided between the electrodes and measuring electronics which causes a controllable current loop to be formed through the physical contacts points between the electrodes and the measuring electronics so that low ohmic contact is established. The control circuitry for the current loop is isolated from the measuring circuitry so that measurements taken are not influenced by the current loop formation.Type: GrantFiled: November 2, 1987Date of Patent: July 10, 1990Assignee: Biologix Inc.Inventors: Douglas J. Littlejohn, Richard L. Fellows