Patents Assigned to BIORESTORATIVE THERAPIES, INC.
  • Patent number: 11066646
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment, the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: July 20, 2021
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Patent number: 10941383
    Abstract: An isolated human brown adipose tissue stem cell line. In one embodiment, the isolated human brown adipose tissue stem cell line expresses the markers CD9, SSEA4, CD44, CD90, CD166, CD73, but not CD14, CD34, CD45 or STRO-1. In another embodiment, the isolated human brown adipose tissue stem cell line expresses the genes UCP1, PPARGC1A, NRF1, FOXC2, CREB1, SIRT3, and WNT5A (REFX). In still another embodiment, the isolated human brown adipose tissue stem cell line is capable of differentiating into osteoblasts, chondrocytes, and adipocytes.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: March 9, 2021
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventor: Francisco Javier Silva
  • Patent number: 10597638
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 24, 2020
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Patent number: 10167449
    Abstract: An isolated human brown adipose tissue stem cell line. In one embodiment, the isolated human brown adipose tissue stem cell line expresses the markers CD9, SSEA4, CD44, CD90, CD166, CD73, but not CD14, CD34, CD45 or STRO-1. In another embodiment, the isolated human brown adipose tissue stem cell line expresses the genes UCP1, PPARGC1A, NRF1, FOXC2, CREB1, SIRT3, and WNT5A (REFX). In still another embodiment, the isolated human brown adipose tissue stem cell line is capable of differentiating into osteoblasts, chondrocytes, and adipocytes.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: January 1, 2019
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventor: Francisco Javier Silva
  • Patent number: 9133438
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: September 15, 2015
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20140212875
    Abstract: A method of distinguishing a brown adipose cell from a white adipose cell. In one embodiment the method includes measuring the expression level of one or more genes in an adipose cell; comparing the measured expression levels to a control, and correlating the expression level of the one or more genes to an identity as a white adipose cell or a brown adipose cell. In one embodiment the one or more genes are selected from the genes listed in FIG. 4C. In another aspect the invention relates to a method of differentiating an adipose stem cell. In one embodiment the method includes inducing differentiation of an adipose stem cell in vitro; and distinguishing the differentiated stem cell. In another embodiment the inducing is performed by contacting the adipose stem cell with a brown adipose cell differentiation media.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 31, 2014
    Applicant: BioRestorative Therapies, Inc.
    Inventor: Francisco Javier Silva
  • Publication number: 20130071360
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: June 28, 2012
    Publication date: March 21, 2013
    Applicant: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Silva, Mark Weinreb, Amit N. Patel, David A. Bull