Patents Assigned to Biosearch Italia S.p.A.
-
Patent number: 6586393Abstract: The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any proportion, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having a selective inhibitory activity against E. coli RNA polymerase.Type: GrantFiled: November 9, 2001Date of Patent: July 1, 2003Assignee: Biosearch Italia S.p.A.Inventors: Ismaela Ciciliato, Emiliana Corti, Edoardo Giacomo Sarubbi, Stefania Stefanelli, Nicoletta Montanini, Flavia Marinelli, Michael Kurz, Enrico Selva
-
Publication number: 20020115597Abstract: The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any proportion, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having a selective inhibitory activity against E. coli RNA polymerase.Type: ApplicationFiled: November 9, 2001Publication date: August 22, 2002Applicant: BIOSEARCH ITALIA S.p.A.Inventors: Ismaela Ciciliato, Emiliana Corti, Edoardo Giacomo Sarubbi, Stefania Stefanelli, Nicoletta Montanini, Flavia Marinelli, Michael Kurz, Enrico Selva
-
Patent number: 6218505Abstract: Improved chemical process for preparing the compounds of formula (I), wherein: R1 represents (C9-C12)alkyl; M represents hydrogen, &agr;-D-mannopyranosyl or 6-O-acetyl-&agr;-D-mannopyranosyl and Y represents an amino group of formula —NR2-alk1-(NR3-alk2)p-(NR4-alk3)q-W. One aspect of the invention refers to the preparation of the intermediate compound of formula (III) (which corresponds to the above compound of formula (I) wherein R1 and M are as above defined and Y is hydroxy), by reacting a compound of formula (II) (which corresponds to the above compound of formula (I) wherein R1 and M are as above defined and Y is hydroxymethyl), with a (C1-C4)alkanol in the presence of a concentrated mineral acid, using the same alkanol as the reaction solvent and submitting the obtained ester compound to a reductive process by adding an alkali metal borohndride into the same reaction mixture.Type: GrantFiled: October 7, 1998Date of Patent: April 17, 2001Assignee: Biosearch Italia S.p.A.Inventors: Gianbattista Panzone, Alessandra Maria Marazzi, Ermenegildo Restelli, Anacleto Gianantonio
-
Patent number: 6143739Abstract: The present invention refers to basic amides derivatives of GE 2270 and GE 2270-like antibiotics of general formula (1), wherein the group GE represents the antibiotic core molecule. The amide derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.Type: GrantFiled: July 31, 1997Date of Patent: November 7, 2000Assignee: Biosearch Italia S.p.A.Inventors: Sergio Lociuro, Pierfausto Seneci, Ermenegildo Restelli, Romeo Ciabatti
-
Patent number: 6080731Abstract: 5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.Type: GrantFiled: July 1, 1998Date of Patent: June 27, 2000Assignees: Biosearch Italia, S.p.A., University of GenoaInventors: Antonio De Flora, Umberto Benatti, Marco Giovine
-
Patent number: 6040297Abstract: 5,5'-Pyrophosphates of non-naturally occurring nucleosides selected from 1-(1-thyminyl)-3-azido-2, 3-dideoxy-D-riboside, 1(5-fluoro-1-uracilyl)-2, 3-dideoxy-D-riboside, 1-(1-uracilyl)-3-azido-2, 3-dideoxy-D-riboside, 1-(9-guaninyl)-2, 3-dideoxy-D-riboside, 1-(9-hypoxanthinyl)-2, 3-dideoxy-D-riboside, 1-(1-cytosinyl)-2, 3-dideoxy-D-riboside, and 1-(9-adeninyl)-2, 3-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutic agents against tumors and retroviral infections including HIV infections. The compounds may be administered as the active ingredients of pharmaceutical compositions or as prodrugs encapsulated within biological carriers, e.g. transformed erythrocytes, for targeting to specific cell populations responsible for the development of the noted pathological disorders.Type: GrantFiled: January 14, 1997Date of Patent: March 21, 2000Assignees: Biosearch Italia, S.p.A., Gruppo Lepetit, S.p.A.Inventors: Antonio De Flora, Umberto Benatti, Marco Giovine
-
Patent number: 6008225Abstract: Mono- or di-substituted derivatives of GE2270 factors C.sub.2a, D.sub.2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) or (c), R.sup.1 and R.sup.2 representing a variety of substituents, X.sup.1 is methyl, X.sup.2 is a --CH.sub.2 --W.sup.1 moiety and X.sup.3 is methylamino or amino, or X.sup.1 is a --CH.sub.2 --W.sup.1 moiety, X.sup.2 is methoxymethylene and X.sup.3 is methylamino, with the proviso that when X.sup.3 is amino, then W must be 2-(aminocarbonyl)-pyrrolidinyl; with the further proviso that when W is 2-(aminocarbonyl)-pyrrolidinyl, then W.sup.1 cannot be hydroxy; and the pharmaceutically acceptable salts thereof. The mono- or di-substituted derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.Type: GrantFiled: June 29, 1998Date of Patent: December 28, 1999Assignee: BioSearch Italia, S.p.A.Inventors: Sergio Lociuro, Paolo Tavecchia, Romeo Ciabatti, Ermenegildo Restelli
-
Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex
Patent number: 5925550Abstract: The present invention relates to a method for selectively enhancing the production of factors A.sub.2 and/or A.sub.3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A/16686 producing culture during fermentation.Type: GrantFiled: December 18, 1997Date of Patent: July 20, 1999Assignee: Biosearch Italia S.p.A.Inventors: Giancarlo Lancini, Angelo Borghi, Piero Antonini -
Patent number: 5891869Abstract: The present invention refers to basic oxazoline-amide derivatives of GE 2270 and GE 2270-like antibiotics of general formula (I), wherein the group GE represents the antibiotic core molecule. The amide derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.Type: GrantFiled: July 31, 1997Date of Patent: April 6, 1999Assignee: Biosearch Italia, S.p.A.Inventors: Sergio Lociuro, Pierfausto Seneci, Romeo Ciabatti
-
Patent number: 5843679Abstract: The present invention is directed to a method for selectively enhancing the production of factors A, and/or B.sub.0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A 40926 producing culture during fermentation.Type: GrantFiled: June 2, 1995Date of Patent: December 1, 1998Assignee: Biosearch Italia S.p.A.Inventors: Enrico Selva, Luciano Gastaldo, Maurizio Denaro, Giovanni Cassani, Francesco Parenti