Patents Assigned to Biotechnology Research and Development Corporation
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Patent number: 10039819Abstract: The present invention provides attenuated M haemolitica strains that elicit an immune response in animal against M haemolitica, compositions comprising said strains, methods of vaccination against M haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: June 15, 2017Date of Patent: August 7, 2018Assignees: The United States of America, as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 10039818Abstract: This disclosure provides attenuated P. multocida strains which can be used to prepare vaccine compositions useful for protection against P. multocida.Type: GrantFiled: May 5, 2016Date of Patent: August 7, 2018Assignees: The United States of America, as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 9744226Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: January 8, 2016Date of Patent: August 29, 2017Assignees: The United States of America, as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 8822661Abstract: Engineered mutant xylose reductases demonstrate higher preference to xylose than arabinose. Amino acid mutations were engineered in to native xylose reductase from Neurospora crassa. Mutant xylose reductases are useful in the production of xylitol and ethanol.Type: GrantFiled: July 10, 2008Date of Patent: September 2, 2014Assignees: The Board of Trustees of the University of Illinois, Biotechnology Research and Development CorporationInventors: Huimin Zhao, Nikhil Unni Nair
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Patent number: 8586059Abstract: This document provides live non-pathogenic M. bovis bacteria and compositions containing live non-pathogenic M. bovis bacteria. This document also provides methods of using live non-pathogenic M. bovis bacteria to immunize cattle against infectious diseases (e.g., diseases caused by M. bovis bacteria). In addition, methods and materials that can be used to generate live non-pathogenic M. bovis bacteria are provided.Type: GrantFiled: June 3, 2009Date of Patent: November 19, 2013Assignees: Iowa State University Research Foundation, Inc., Biotechnology Research and Development CorporationInventors: Ricardo Rosenbusch, Nakhyung Lee
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Patent number: 8367346Abstract: The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.Type: GrantFiled: May 11, 2011Date of Patent: February 5, 2013Assignees: Biotechnology Research Development Corporation, The United States of America, as represented by Sec. of AgricultureInventors: Paul Taylor, Nathan Wymer, Francis Michael Racine
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Patent number: 8357353Abstract: A chemical composition comprising a linker agent and a compound comprising at least one UV-absorbing chromophore, wherein the linker agent is characterized by the general formula: wherein X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group that bonds with the compound comprising at least one UV-absorbing chromophore, and b+f?2, Y comprises an O, N, or S that is substituted or unsubstituted, each a, b, c, e and f is ?0 and a+b+c+e+f?2, d is 0 or 1, n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies, and m ranges from 1 to about 100 and each individual m unit may be the same or different.Type: GrantFiled: May 10, 2010Date of Patent: January 22, 2013Assignees: Biotechnology Research & Development Corporation, United States Department of AgricultureInventors: Joseph A. Laszlo, David L. Compton, Louis J. DeFilippi, Steven Grall
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Patent number: 8114638Abstract: Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously expressed arabinitol dehydrogenases are useful in converting biomass into biofuels and other industrial food products.Type: GrantFiled: January 4, 2011Date of Patent: February 14, 2012Assignees: The Board of Trustees of the University of Illinois, Biotechnology Research and Development CorporationInventors: Huimin Zhao, Ryan Sullivan
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Publication number: 20110165631Abstract: Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously expressed arabinitol dehydrogenases are useful in converting biomass into biofuels and other industrial food products.Type: ApplicationFiled: January 4, 2011Publication date: July 7, 2011Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Biotechnology Research And Development CorporationInventors: Huimin Zhao, Ryan Sullivan
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Patent number: 7960152Abstract: The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.Type: GrantFiled: May 19, 2005Date of Patent: June 14, 2011Assignee: Biotechnology Research Development CorporationInventors: Paul Taylor, Ian Fotheringham, Nathan Wymer, Badal Saha, David Demirjian, Yoshikiyo Sakaibara, Francis Michael Racine
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Patent number: 7892804Abstract: Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously expressed arabinitol dehydrogenases are useful in converting biomass into biofuels and other industrial food products.Type: GrantFiled: September 22, 2008Date of Patent: February 22, 2011Assignees: The Board of Trustees of the University of Illinois, Biotechnology Research and Development CorporationInventors: Huimin Zhao, Ryan Sullivan
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Publication number: 20100291645Abstract: Engineered mutant xylose reductases demonstrate higher preference to xylose than arabinose. Amino acid mutations were engineered in to native xylose reductase from Neurospora crassa. Mutant xylose reductases are useful in the production of xylitol and ethanol.Type: ApplicationFiled: July 10, 2008Publication date: November 18, 2010Applicant: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATIONInventors: Huimin Zhao, Nikhil Unni Nair
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Publication number: 20100215600Abstract: A chemical composition comprising a linker agent and a compound comprising at least one UV-absorbing chromophore, wherein the linker agent is characterized by the general formula: wherein X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group that bonds with the compound comprising at least one UV-absorbing chromophore, and b+f?2, Y comprises an 0, N, or S that is substituted or unsubstituted, each a, b, c, e and f is ?0 and a+b+c+e+f?2, d is 0 or 1, n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies, and m ranges from 1 to about 100 and each individual m unit may be the same or different.Type: ApplicationFiled: May 10, 2010Publication date: August 26, 2010Applicants: BIOTECHNOLOGY RESEARCH & DEVELOPMENT CORPORATION, UNITED STATES DEPARTMENT OF AGRICULTUREInventors: Joseph A. Laszlo, David L. Compton, Louis J. DeFilippi, Steven Grall
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Publication number: 20100151529Abstract: Phosphite dehydrogenase mutant enzymes provide relaxed cofactor specificity, increased thermostability, increased activity, solubility, and expression over the wild-type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.Type: ApplicationFiled: April 18, 2008Publication date: June 17, 2010Applicant: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATIONInventors: Huimin Zhao, Michael McLachlan, Tyler Johannes
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Publication number: 20100151097Abstract: High colicin producing bacteria strains are produced by introducing into a host cell multiple copies of a plasmid containing a colicin gene. A suitable host cell is a bacterium strain, Escherichia coli K-12 and examples of plasmids are pColE1-K53 or pColN-284.Type: ApplicationFiled: March 25, 2008Publication date: June 17, 2010Applicants: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION, IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventor: Chad H. Stahl
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Patent number: 7727514Abstract: A chemical composition comprising a linker agent and a compound comprising at least one UV-absorbing chromophore, wherein the linker agent is characterized by the general formula: wherein X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group that bonds with the compound comprising at least one UV-absorbing chromophore, and b+f?2, Y comprises an O, N, or S that is substituted or unsubstituted, each a, b, c, e and f is ?0 and a+b+c+e+f?2, d is 0 or 1, n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies, and m ranges from 1 to about 100 and each individual m unit may be the same or different.Type: GrantFiled: June 19, 2006Date of Patent: June 1, 2010Assignees: Biotechnology Research & Development Corporation, United States of America Department of AgricultureInventors: Joseph A. Laszlo, David L. Compton, Louis J. DeFilippi, Steven Grall
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Publication number: 20090325254Abstract: A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.Type: ApplicationFiled: September 1, 2009Publication date: December 31, 2009Applicants: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Huimin Zhao, Ryan Woodyer, Michael Simurdiak, Wilfred A. van der Donk
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Patent number: 7592163Abstract: A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.Type: GrantFiled: May 19, 2008Date of Patent: September 22, 2009Assignees: The Board of Trustees of the University of Illinois, Biotechnology Research and Development CorporationInventors: Huimin Zhao, Ryan Woodyer, Michael Simurdiak, Wilfred A. van der Donk
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Patent number: 7572610Abstract: A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates, and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxylates, when present, are the same or different, comprising (a) partially deacylating a triacylglycerol so as to provide a mono- or diacylglycerol, (b) reacting in a reaction mixture an acyl ester of the phytochemical with said mono- or diacylglycerol in the presence of a esterase catalyst under conditions that permit transesterification of said ester with said mono- or diacylglycerol, and (c) recovering said compound from said reaction mixture.Type: GrantFiled: June 19, 2006Date of Patent: August 11, 2009Assignees: Biotechnology Research & Development Corporation, The United States of America as represented by the Department of AgricultureInventors: Joseph A. Laszlo, David L. Compton, Louis J. DeFilippi, Steven Grall
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Publication number: 20090081734Abstract: Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously expressed arabinitol dehydrogenases are useful in converting biomass into biofuels and other industrial food products.Type: ApplicationFiled: September 22, 2008Publication date: March 26, 2009Applicants: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Huimin Zhao, Ryan Sullivan