Abstract: Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.
Type:
Grant
Filed:
March 16, 1988
Date of Patent:
February 14, 1989
Assignee:
Biotechnology Research Associates, J.V.
Inventors:
John A. Lewicki, Robert M. Scarborough, Jr., Lorin K. Johnson
Abstract: Methods and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator polypeptides to said host. Also provided are methods for producing such polypeptides, and antibodies which are capable of recognizing and specifically binding to them.
Type:
Grant
Filed:
May 8, 1985
Date of Patent:
August 16, 1988
Assignee:
Biotechnology Research Associates J.V.
Inventors:
Lorin K. Johnson, Steven A. Atlas, Brian J. McCarthy, John H. Laragh, John A. Lewicki
Abstract: Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.
Type:
Grant
Filed:
May 28, 1986
Date of Patent:
July 12, 1988
Assignee:
Biotechnology Research Associates J.V.
Inventors:
John A. Lewicki, Robert M. Scarborough, Jr., Lorin K. Johnson
Abstract: Methods and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering auriculin or a synthetic analog of auriculin to said host.
Type:
Grant
Filed:
April 19, 1984
Date of Patent:
October 21, 1986
Assignee:
Biotechnology Research Associates, J.V.
Inventors:
Lorin K. Johnson, Steven A. Atlas, John H. Laragh