Patents Assigned to Board of Regents The University of Texas System
  • Patent number: 10669516
    Abstract: A bioreactor system for conditioning of pluripotent cells or cell media is provided. In further aspects, conditioned pluripotent cells and methods for making such cells are provided.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: June 2, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Charles S. Cox, Jr., Brijesh S. Gill, Kevin Aroom, Pamela Wenzel
  • Patent number: 10669399
    Abstract: Disclosed herein are self-healing conductive network compositions. The networks can contain one or more conductive polymers and one or more supramolecular complexes. The supramolecular complex can be introduced into conductive polymer matrix, resulting in a network of the two components. In this network, the nanostructured conductive polymer gel constructs a 3D network to promote the transport of electrons and mechanically reinforce the network while the supramolecular complex contributes to self-healing property and also conductivity. The networks disclosed herein are useful for various applications such as self-healing electronics, artificial skins, soft robotics and biomimetic prostheses.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: June 2, 2020
    Assignees: Board of Regents, The University of Texas System, Texas State University
    Inventors: Guihua Yu, Ye Shi, Xiaopeng Li
  • Patent number: 10668085
    Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 2, 2020
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLC
    Inventors: Chris Brough, James W. McGinity, Dave A. Miller, James C. DiNunzio, Robert O. Williams, III
  • Publication number: 20200165750
    Abstract: The present disclosure relates to an improved method for preparing carbon fiber via modified stabilization and carbonization methods during a process of forming filaments of co-polymers comprising acrylonitrile (AN) and vinyl imidazole (VIM) by adding an additive during the during the extrusion process to decrease stabilization temperature, increase crosslinking during oxidation, or decrease the temperatures of carbonization.
    Type: Application
    Filed: May 9, 2018
    Publication date: May 28, 2020
    Applicants: Korea Institute of Carbon Convergence Technology, The Board of Regents of the University of Texas System
    Inventors: Min Hye JUNG, Hyun Kyu SHIN, Kyu Soon PARK, Duck Joo YANG, Benjamin BATCHELOR, Samsuddin MAHMOOD
  • Publication number: 20200165339
    Abstract: Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a chimeric CD 154 polypeptide. Also provided herein are methods of enhanced immune function.
    Type: Application
    Filed: November 2, 2016
    Publication date: May 28, 2020
    Applicants: Board of Regents, The University of Texas System, Memgen, LLC
    Inventors: Willem W. OVERWIJK, Manisha SINGH, Patrick HWU, Mark CANTWELL
  • Patent number: 10660850
    Abstract: The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: May 26, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Keith P. Johnston, Joshua Engstrom, Jasmine Rowe, Alan B. Watts, Robert O. Williams, III
  • Patent number: 10660585
    Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 26, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hak Choy, Steve Jiang, Robert Timmerman, Arnold Pompos
  • Patent number: 10660586
    Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 26, 2020
    Assignee: The Board of Regents of the University of Texas Systems
    Inventors: Hak Choy, Steve Jiang, Robert Timmerman, Arnold Pompos
  • Patent number: 10660587
    Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 26, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Hak Choy, Steve Jiang, Robert Timmerman, Arnold Pompos
  • Patent number: 10661095
    Abstract: Disclosed is the use of copper cysteamine nanoparticles for use in photodynamic cancer therapy. The disclosed methods of treatment utilize microwave radiation as a means for activating the copper cysteamine photosensitizer.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: May 26, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Wei Chen, Lun Ma
  • Patent number: 10663474
    Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: May 26, 2020
    Assignees: The Governing Council of the University of Toronto, Board of Regents, The University of Texas System
    Inventors: Sachdev S. Sidhu, Sarah L. Barker, Orson W. Moe, Makoto Kuro-o, Johanne Pastor
  • Publication number: 20200162242
    Abstract: The techniques described herein may provide an efficient and secure two-party distributed signing protocol, for example, for the IEEE P1363 standard. For example, in an embodiment, method may comprise generating, at a key generation center, a first partial private cryptographic key for a user ID and a second partial private cryptographic key for the user ID, transmitting the first partial private cryptographic key to a first other device, transmitting the second partial private cryptographic key to a second other device, and generating a distributed cryptographic signature for a message using the first partial private cryptographic key and the second partial private cryptographic key.
    Type: Application
    Filed: November 19, 2019
    Publication date: May 21, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kim Kwang Choo, Debiao He
  • Publication number: 20200155834
    Abstract: The present disclosure provides methods of making and applying metallized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.
    Type: Application
    Filed: November 21, 2019
    Publication date: May 21, 2020
    Applicants: Board of Regents, The University of Texas System, University of Wollongong
    Inventors: Mario ROMERO-ORTEGA, Gordon Wallace, Maria Gonzalez Gonzalez, Rouhollah Ali Jalili
  • Publication number: 20200157146
    Abstract: The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.
    Type: Application
    Filed: June 6, 2019
    Publication date: May 21, 2020
    Applicants: Board of Regents, The University of Texas System, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Constantin G. Ioannides, Martin L. Campbell, Catherine A. O'Brian, George E. Peoples
  • Publication number: 20200157264
    Abstract: A quad-polymer composition includes monomers of (a) acrylonitrile, (a) vinylimidazole, (c) methyl acrylate and (d) either acrylic acid or itaconic acid. Such quad-polymer compositions may be used to form fibers (such as by melt spinning) that may then be annealed, stabilized, and/or carbonized to produce carbon fibers. The quad-polymer composition may be used for supercapacitors, lithium battery electrodes once carbonized, and as synthesized, it may be used for wound healing fibers, fabrics, coatings, and films, and anti-bacterial/anti-microbial fibers, fabrics, coatings and films. The carbon fibers formed from the quad-polymer composition may be used for the fiber composites for automobile, aerospace structures, marine structures, military equipment/parts, sporting goods, robotics, furniture, and electronic parts.
    Type: Application
    Filed: May 9, 2018
    Publication date: May 21, 2020
    Applicants: KOREA INSTITUTE OF CARBON CONVERGENCE TECHNOLOGY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Min Hye JUNG, Hyun Kyu SHIN, Kyu Soon PARK, Duck Joo YANG, Benjamin BATCHELOR, Samsuddin MAHMOOD
  • Publication number: 20200157637
    Abstract: Methods for identifying patients with high risk (progression, invasion, metastasis) squamous cell carcinoma using methylation and/or expression assays are disclosed. Also provided are methods of treating such high risk cancers with ALK inhibitors combined with anti-EGFR based therapies, as the data show a correlation between ALK hypomethylation and EGFR activation.
    Type: Application
    Filed: May 23, 2018
    Publication date: May 21, 2020
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cara B. GONZALES, Nameer KIRMA
  • Patent number: 10653150
    Abstract: Methods of forming antimicrobial resin compositions comprising silver nanoparticles are disclosed, wherein the resin compositions that are generated exhibit lower initial color, reduced color shift upon storage and reduced levels of spontaneous polymerization. Such methods generally comprise: combining a silver-containing material with a self-cure and dual-cure base resin in situ wherein the base resin does not contain a catalytic amine; and adding a catalytic resin to the mixture of the resin and silver-containing material in order to form the final cured resin. Antimicrobial polymeric materials formed by said methods are also disclosed.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: May 19, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Kyumin Whang
  • Patent number: 10653538
    Abstract: This disclosure includes bubble actuator arrays and methods for making and using the same. Some bubble actuator arrays include a first flexible layer having a substantially flat first portion and a plurality of second portions that protrude away from the first portion to define chambers, a flexible second layer sealed to the first layer to define a plurality of cells in the chambers and between the layers, and where the array can be coupled to a fluid source such that the internal pressures of the cells can be varied. Some of the present methods include adjusting with a processor and fluid source the pressure in the cells of an array. Others of the present methods include placing sacrificial material into chambers of a molded first layer such that a plurality of cells is formed when a second layer is molded coincident to the first and the sacrificial material is removed.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: May 19, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Muthu Wijesundara, Wei Carrigan
  • Patent number: 10660214
    Abstract: Systems and methods for creating interlayer mechanical or electrical attachments or connections using filaments within a three-dimensional structure, structural component, or structural electronic, electromagnetic, or electromechanical component/device.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: May 19, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ryan B. Wicker, Francisco Medina, Eric MacDonald, Danny W. Muse, David Espalin
  • Patent number: 10657378
    Abstract: A method, system and computer program product for classifying an image or video. An image or video to be classified is received. Scene statistics (statistical model of pictures, images or videos representative of pictures, images or videos, respectively, that are captured of the physical world) of the image or video are captured. A model (a statistical model that describes a set of probability distributions) of the image or video is then created using the captured scene statistics. A comparison between the model of the image or video with two other models of images or videos is performed, such as a model of visible light images or videos and a model of infrared images or videos. The received image or video is then classified (e.g., classified as corresponding to a visible light image) based on the comparison.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 19, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Alan Bovik, Todd Goodall