Abstract: Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.

Abstract: A proton-conducting solid oxide electrolyte membrane includes a nanoporous layer including a plurality of nanopores that penetrate from one surface to the other, and at least one proton conducting layer that fills the plurality of nanopores to have an interface in a direction perpendicular to either surface of the nanoporous layer.

Abstract: The present invention features methods for induction of angiogenesis by administration of nicotine or other nicotine receptor agonist. Induction of angiogenesis by the methods of the invention can be used in therapeutic angiogenesis in, for example, treatment of ischemic syndromes such as coronary or peripheral arterial disease.

Abstract: The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).

Abstract: A method of manufacturing a proton conductive solid oxide fuel cell, the method including: forming a metallic mask layer having nanoholes on a first surface of a substrate; selectively etching the first surface of the substrate using the metallic mask layer; depositing a first membrane electrode assembly (MEA) member on the etched first surface of the substrate; etching an opposing second surface of the substrate; and forming second and third MEA members on the first MEA member.

Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.

Abstract: A method for providing panoramic videos and images to a user using a server-client architecture while minimizing the wait time necessary before still images are available for viewing or videos begin playing. A series of location-referenced panoramic images are separated into one-dimensional tracks. Intuitive user controls are provided which allow the user to start and stop video playback, step through the panoramas in a track one at a time, and change the viewing orientation within the panorama. A video will start playing as soon as the video files for the preferred projected cube faces have been downloaded. This delay is reduced by storing the videos as keyframe distance files for opposing directions for each cube face and further reduced by encoding videos with different starting points so that they are staggered by a portion of the keyframe distance.

Abstract: A proton conducting electrolyte membrane comprising a ceramic electrolyte layer including an inorganic proton conductor and a ceramic protective layer formed on at least one surface of the ceramic electrolyte layer and having proton conductivity; a membrane electrode assembly including the proton conducting electrolyte membrane; and a proton conducting ceramic fuel cell including the membrane electrode assembly. In the proton conducting electrolyte membrane, the ceramic protective layer may have an improved chemical bond with the ceramic electrolyte layer compared with a Pd metal protective layer, such that interlayer delamination may be lessened. Also, compared with a Pd metal protective layer, the ceramic protective layer is more appropriate for ceramic electrolytes such as BYZ and BYC that transmit protons or simultaneously transmit protons and oxygen ions used in a fuel cell operating at a temperature range of about 200 to about 500° C., for example, about 250 to about 500° C.

Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.

Abstract: Adaptive rule-based methods to solve localization problems for ad hoc wireless sensor networks are disclosed. A large problem may be solved as a sequence of very small subproblems, each of which is solved by semidefinite programming relaxation of a geometric optimization model. The subproblems may be generated according to a set of sensor/anchor selection rules and a priority list. The methods scale well and provide improved positioning accuracy. A dynamic version may be used for estimating moving sensors locations in a real-time environment. The method may use dynamic distance measurement updates among sensors, and utilizes subproblem solving for static sensor localization. Methods to deploy sensor localization algorithms in clustered distributed environments are also provided, permitting application to arbitrarily large networks. In addition, the methods may be used to solve sensor localizations in 2D or 3D space. A preprocessor may be used for localization of networks without absolute position information.

Abstract: Adaptive rule-based methods to solve localization problems for ad hoc wireless sensor networks are disclosed. A large problem may be solved as a sequence of very small subproblems, each of which is solved by semidefinite programming relaxation of a geometric optimization model. The subproblems may be generated according to a set of sensor/anchor selection rules and a priority list. The methods scale well and provide improved positioning accuracy. A dynamic version may be used for estimating moving sensors locations in a real-time environment. The method may use dynamic distance measurement updates among sensors, and utilizes subproblem solving for static sensor localization. Methods to deploy sensor localization algorithms in clustered distributed environments are also provided, permitting application to arbitrarily large networks. In addition, the methods may be used to solve sensor localizations in 2D or 3D space. A preprocessor may be used for localization of networks without absolute position information.

Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.

Abstract: In response to a user request, a computer generates a graphical user interface on a computer display. A schema information region of the graphical user interface includes multiple operand names, each operand name associated with one or more fields of a multi-dimensional database. A data visualization region of the graphical user interface includes multiple shelves. Upon detecting a user selection of the operand names and a user request to associate each user-selected operand name with a respective shelf in the data visualization region, the computer generates a visual table in the data visualization region in accordance with the associations between the operand names and the corresponding shelves. The visual table includes a plurality of panes, each pane having at least one axis defined based on data for the fields associated with a respective operand name.

Abstract: ?v?3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic ?v?3 integrin antagonist.

Abstract: A system and method for parallel imaging is disclosed that generates linear combination coefficient weights by solving systems of linear equations formulated with correlation values. An MRI apparatus includes a computer programmed to acquire MR data from an imaging volume for a plurality of encoding locations using an array of RF receiver coils. Correlation values are calculated from the MR data. From these calculated correlation values, synthesis weights are generated. An image is then reconstructed based on an application of the synthesis weights to at least a portion of the MR data acquired from the array of RF receiver coils.

Abstract: A method for forming a visual plot using a hierarchical structure of a dataset. The dataset comprises a measure and a dimension. The dimension consists of a plurality of levels. The plurality of levels form a dimension hierarchy. The visual plot is constructed based on a specification. A first level from the plurality of levels is represented by a first component of the visual plot. A second level from the plurality of levels is represented by a second component of the visual plot. The dataset is queried to retrieve data in accordance with the specification. The data includes all or a portion of the dimension and all or a portion of the measure. The visual plot is populated with the retrieved data in accordance with the specification.

Abstract: Methods are provided for use in treating humans suffering from irritable bowel syndrome. In the subject methods, an effective amount of a nerve-acting agent, e.g., lidocaine, topiramate, mexiletine and gabapentin, etc., is administered to a human suffering from irritable bowel syndrome. Also provided are pharmaceutical compositions and kits for use in practicing the subject methods.

Abstract: A method and system for producing graphics. A hierarchical structure of a database is determined. A visual table, comprising a plurality of panes, is constructed by providing a specification that is in a language based on the hierarchical structure of the database. In some cases, this language can include fields that are in the database schema. The database is queried to retrieve a set of tuples in accordance with the specification. A subset of the set of tuples is associated with a pane in the plurality of panes.

Abstract: The present invention provides a system and method for parallel imaging that performs auto-calibrating reconstructions with a 2D (for 2D imaging) or 3D kernel (for 3D imaging) that exploits the computational efficiencies available when operating in certain data “domains” or “spaces”. The reconstruction process of multi-coil data is separated into a “training phase” and an “application phase” in which reconstruction weights are applied to acquired data to synthesize (replace) missing data. The choice of data space, i.e., k-space, hybrid space, or image space, in which each step occurs is independently optimized to reduce total reconstruction time for a given imaging application. As such, the invention retains the image quality benefits of using a 2D k-space kernel without the computational burden of applying a 2D k-space convolution kernel.

Abstract: The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline receptor antagonist. The methods are useful to treat conditions associated with or resulting from angiogenesis, particularly pathological angiogenesis. The invention further provides methods of treating a condition associated with or resulting from angiogenesis.