Abstract: A method for treating a subject with symptoms of tinnitus and pharmaceutical compositions for treating tinnitus, the pharmaceutical compositions comprising one or more of the following: sazetidine, a pharmaceutically acceptable salt of sazetidine, varenicline, a pharmaceutically acceptable salt of varenicline, or any combination thereof.
Type:
Grant
Filed:
February 6, 2020
Date of Patent:
March 5, 2024
Assignee:
Board of Trustees of Southern Illinois University
Inventors:
Donald Caspary, Thomas Brozoski, Brandon Cox
Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
Type:
Grant
Filed:
November 27, 2019
Date of Patent:
December 5, 2023
Assignees:
Board of Trustees of Southern Illinois University, Vanderbilt University
Inventors:
Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
Abstract: Nanoparticles comprising resiniferatoxin (RTX) encapsulated in a poly(lactic-co-glycolic acid) (PLGA) polymer and compositions, especially topical compositions, comprising the nanoparticles. The compositions can be used as topical formulations for ameliorating pain, including for diabetic patients with peripheral neuropathy.
Type:
Grant
Filed:
July 10, 2020
Date of Patent:
July 25, 2023
Assignees:
BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, UNIVERSITY OF WYOMING
Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
Type:
Application
Filed:
January 4, 2023
Publication date:
May 18, 2023
Applicants:
Board of Trustees of Southern Illinois University, Vanderbilt University
Inventors:
Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
Abstract: The present invention is directed to a transgenic soybean plant having increased seed protein content and/or increased seed oil content comprising a polynucleotide encoding a ?-ConGlycinin soybean seed storage promoter that functions in the soybean plant operably linked to a polynucleotide encoding a soybean seed storage polypeptide having ?-ConGlycinin activity. The invention is further directed to a method of increasing seed protein content and/or increasing seed oil content of a soybean plant comprising transforming the soybean plant with a polynucleotide encoding a ?-ConGlycinin soybean seed storage promoter that functions in the soybean plant operably linked to a polynucleotide encoding a soybean seed storage polypeptide having ?-ConGlycinin activity.
Type:
Application
Filed:
October 28, 2022
Publication date:
May 18, 2023
Applicant:
Board of Trustees of Southern Illinois University
Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
Type:
Grant
Filed:
February 17, 2020
Date of Patent:
February 7, 2023
Assignees:
Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
Inventors:
Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
Type:
Application
Filed:
February 17, 2020
Publication date:
January 5, 2023
Applicants:
Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
Inventors:
Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
Abstract: A multifunctional camera system having a bendable arm configured to be inserted into the thoracic cavity of a patient and camera head at a distal end of the bendable arm. The camera head has a high definition video camera and a light source. The camera head has a view adjustment mechanism for changing a view angle of the camera without changing the position of the camera head. A controller controls the view adjustment mechanism under command of a surgeon.
Type:
Grant
Filed:
April 5, 2019
Date of Patent:
December 20, 2022
Assignee:
Board of Trustees of Southern Illinois University
Inventors:
Traves Crabtree, Timothy York, Mitch McKay, Mingshao Zhang
Abstract: The present invention is directed to a transgenic soybean plant having increased oleic acid content comprising a polynucleotide comprising a fatty acid thioesterase (FAT) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAT activity. The invention is further directed to a method of increasing oleic acid content of a soybean plant comprising transforming a soybean plant with a polynucleotide comprising a fatty acid thioesterase (FAT) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAT activity.
Type:
Application
Filed:
May 27, 2022
Publication date:
December 1, 2022
Applicant:
Board of Trustees of Southern Illinois University
Abstract: The present invention is directed to a transgenic soybean plant with increased oleic acid content comprising a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity. The invention is also related to a plant of an agronomically elite soybean variety with increased oleic acid content comprising a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity. The invention is still further directed to a method of increasing the oleic acid content of a soybean plant comprising transforming the soybean plant with a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity.
Type:
Application
Filed:
May 16, 2022
Publication date:
November 17, 2022
Applicant:
Board of Trustees of Southern Illinois University
Abstract: A pathogen transport modelled biomimetic sensor includes a stack of capacitive electrodes with a plurality of gaps therebetween. The gaps and electrodes are structured and arranged to model an outer layer and one or more sublayers of fresh food of interest. The electrodes are arranged to provide multiple measurable impedances that are affected in response to cell or polymeric biofilm presence that affects the electrostatic field around and between the electrodes and consequently changes the measurable impedances.
Type:
Grant
Filed:
March 19, 2020
Date of Patent:
October 25, 2022
Assignee:
Board of Trustees of Southern Illinois University
Inventors:
Mohammad Shavezipur, Minako Sumita, Roya Mazrouei
Abstract: Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.
Type:
Grant
Filed:
May 13, 2019
Date of Patent:
August 30, 2022
Assignees:
NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Carol Podlasek, Samuel I. Stupp, Kevin McVary, Dan Harrington
Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
Type:
Grant
Filed:
September 22, 2017
Date of Patent:
April 19, 2022
Assignees:
Board of Trustees of Southern Illinois University
Inventors:
Keith Gagnon, Masad Damha, Elise Malek-Adamian, Maryam Habibian, Daniel Timothy O'Reilly, Zachery Kartje
Abstract: The present disclosure relates to compositions and methods for inhibiting the growth of, decreasing the amount of, and abolishing the growth of mutans streptococci.
Type:
Grant
Filed:
August 23, 2019
Date of Patent:
September 14, 2021
Assignee:
The Board of Trustees of Southern Illinois University
Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
Type:
Application
Filed:
February 17, 2020
Publication date:
August 19, 2021
Applicants:
Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
Inventors:
Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
Abstract: Systems and methods for magnetic induction of a penile prosthesis are disclosed. The magnetic induction system includes a wand that has a coil arrangement covered with a thermal and electrical insulator sheath operable to generate an alternating magnetic field. The coil arrangement of the sheath is configured to receive the length of the penile prosthesis therein. The penile prosthesis may be made from a shape memory material such that application of alternating magnetic fields generated by the magnetic induction system induces eddy currents that raise the temperature of the penile prosthesis to a temperature above the austenitic transformation temperature that allows the penile prosthesis to achieve an erect state.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
June 8, 2021
Assignee:
The Board of Trustees of Southern Illinois University
Inventors:
Alberto Colombo, Kevin McVary, Brian Le