Abstract: The invention relates to PYY analogues having alanine at position 4, lysine at position 7, QRY as the C-terminal end and a half-life extending group. The analogues of the invention are soluble around pH 6 and 7. The invention also relates to pharmaceutical compositions comprising such PYY analogues, and to the medical use of the analogues.
Type:
Grant
Filed:
December 20, 2022
Date of Patent:
August 6, 2024
Assignee:
Boehringer Ingelheim Internatioal GmbH
Inventors:
Peter Wilhelm Haebel, Albert Brennauer, Charlotte Stahl Madsen, Soren Ljungberg Pedersen, Stefan Peters
Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
Type:
Grant
Filed:
December 23, 2014
Date of Patent:
December 1, 2015
Assignee:
Boehringer Ingelheim Internatioal GmbH
Inventors:
Waldemar Pfrengle, Markus Frank, Thomas Klein