Patents Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG
  • Patent number: 10112019
    Abstract: An inhaler for use with a dry powder pharmaceutical formulation, including: a chamber containing the dry powder formulation, a valve disposed in series with the chamber for regulating air flow through the chamber, and a bypass coupled around the combination of the chamber and the valve, where the valve and bypass cooperate for ensuring that the air flow is at least essentially fixed or kept constant or at a minimum accepted or desired or required flow rate through the chamber, and for varying air flow restriction through the inhaler with flow rate, or for keeping the air flow restriction generally constant.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: October 30, 2018
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Stephen T. Dunne
  • Publication number: 20180236386
    Abstract: A cleaning method for sectional cleaning of a filter is proposed, the filter having several filter sections, by means of one cleaning process one of the filter sections at a time being cleaned, the filter sections being cleaned within one cleaning cycle in cleaning processes separated in time from one another, the cleaning method having at least two cleaning cycles and both one time interval between the cleaning processes within the respective cleaning cycle and also one time interval between the end of one of the cleaning cycles and the start of a following one of the cleaning cycles being changed, and/or the filter having at least three filter sections, the filter sections being cleaned in cleaning processes separated by time intervals from one another and the time intervals between successive cleaning processes being changed.
    Type: Application
    Filed: October 14, 2015
    Publication date: August 23, 2018
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventor: Rainer BAUER
  • Patent number: 9604017
    Abstract: The invention relates to a powder inhaler with at least one specially sharpened needle, to ensure the precise piercing or cutting open of capsules and hence the optimum delivery of powdered medicament compositions, medicament formulations or medicament mixtures, as well as ensuring that little effort is needed to perforate or cut open the capsule.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: March 28, 2017
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Hubert Hoelz, Stefan Lustenberger, Torsten Kuehn, Herbert Wachtel, Rolf Kuhn
  • Patent number: 9364841
    Abstract: An inhaler including a pre-inserted cartridge (100) is proposed. The cartridge contains liquid (103) which is preferably pressurized to a low pressure. The cartridge is connected via an aerosol valve (106) with the inhaler. The liquid is further pressurized by a pump (117) of the inhaler to a high pressure and atomized.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: June 14, 2016
    Assignee: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Stephen T. Dunne, Heinrich Kladders
  • Patent number: 9259540
    Abstract: A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed, which nozzle comprises two holes formed in a flat plate which plate is then deformed such that the axes of the holes intersect so that jets of fluids moving through the holes impinge with each other.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: February 16, 2016
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Stephen Terence Dunne
  • Patent number: 9156835
    Abstract: The invention relates to a method for producing a micronized, virtually anhydrous form of (1?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide, said form per se, and the use thereof for producing a medicament, especially a medicament having an anticholinergic effect.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: October 13, 2015
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Norbert Rasenack, Michael Walz, Michael Trunk, Hagen Graebner
  • Patent number: 9045776
    Abstract: The invention relates to DNA-sequences, especially transcription- or expression-enhancing elements (TE elements) and their use on an expression vector in conjunction with an enhancer, a promoter, a product gene and a selectable marker. TE elements bring about an increase in the expression of the product gene, particularly when stably integrated in the eukaryotic genome, preferably the CHO-DG44 genome.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: June 2, 2015
    Assignee: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Barbara Enenkel, Kerstin Sautter
  • Patent number: 9010323
    Abstract: An inhaler (1) includes a sieve part (9) for administrating powdered substances such as medical substances. The inhaler (1) includes a suction air channel (6) leading to a mouthpiece (4), a substance supply container (8) that is moveable inside a receiving chamber (7) and the sieve part (9) disposed in the suction air channel (6) between the receiving chamber (7) and the mouthpiece (4). The sieve part includes a retaining edge (10), a sieve area contained in a cross sectional area within the retaining edge (10), and a protruding area (12) that protrudes to one side and has a flat portion (13).
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: April 21, 2015
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Lukas Haerder, Claus Breuer
  • Patent number: 8975391
    Abstract: The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned genes and to the production of various polypeptides in host cells using said novel regulatory elements. Additionally, the invention relates to uses of said novel regulatory elements as insulators, in gene therapy or for improving host cell lines.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: March 10, 2015
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Barbara Enenkel
  • Patent number: 8969568
    Abstract: The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6, R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as wel
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: March 3, 2015
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Matthias Hoffmann, Georg Dahmann, Dennis Fiegen, Sandra Handschuh, Jasna Klicic, Guenter Linz, Gerhard Schaenzle, Andreas Schnapp, Stephen Peter East, Michael Philip Mazanetz, Robert John Scott, Edward Walker
  • Patent number: 8962312
    Abstract: The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a DHFR expression cassette. Those cell lines have improved growth characteristics in comparison to DHFR-deficient or DHFR-reduced cell lines such as CHO DG44 and CHO DUKX-B11. The invention especially concerns two cell lines, a representative of each cell line is deposited with the DSMZ under the number DSM ACC2909 (CHOpper® Discovery) and DSM ACC2910 (CHOpper® Standard). The invention further concerns a method of producing proteins using the cells generated by the described method.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: February 24, 2015
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Hitto Kaufmann, Lore Florin, Eric Becker, Joey M. Studts
  • Publication number: 20140323732
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Joerg BRANDENBURG, Waldemar PFRENGLE
  • Publication number: 20140286879
    Abstract: A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.
    Type: Application
    Filed: June 12, 2014
    Publication date: September 25, 2014
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Thierry BOUYSSOU, Michael Paul PIEPER, Andreas SCHNAPP
  • Patent number: 8739969
    Abstract: The invention relates to a folding box made from a one-piece cardboard blank (28) comprising an integrally formed hinged lid (7) that overlaps an upper end area of a rectangular-cuboid-shaped body (1) on three sides, is connected to a rear wall (5) of the body (1) through a fold line (6), and lies flush on a front wall (4) and two side walls (3) in the closed state, and having a front panel (9) and two side panels (10) that form a collar (11) that protrudes into the hinged lid (7), wherein the front panel (9) is arranged parallel to and at a distance from the front wall (4) and divides the body (1) into a main compartment (12) and a front compartment (13).
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: June 3, 2014
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Reinhard Schuld
  • Patent number: 8722694
    Abstract: The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rc, A to E and X are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: May 13, 2014
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank Himmelsbach, Elke Langkopf, Thomas Metz, Flavio Solca, Birgit Jung, Anke Baum
  • Patent number: 8714151
    Abstract: An atomizing device (1), an inhaler and a method for dispensing a liquid formulation (5) are proposed. An insert (2) comprises a cylinder (4) filled with the liquid, an atomizing nozzle (7) and a piston (6). The piston is moved in the cylinder to pressurize the liquid and force it out of cylinder through the atomizing nozzle in order to generate a spray (13). The insert is received in a holder (3) which is sealed. The insert is moved within the holder so that the sealing (9) is ruptured before the spray is generated.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: May 6, 2014
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Stephen T. Dunne
  • Publication number: 20140116435
    Abstract: An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, ?{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 ?m, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 pm to 500 ?m, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 ?{square root over (kPa)} min/L containing the inhalable powder.
    Type: Application
    Filed: December 19, 2013
    Publication date: May 1, 2014
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventor: Bernd ZIERENBERG
  • Publication number: 20140076308
    Abstract: A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed. The nozzle comprises two holes formed in a flat plate. Then, the plate is deformed such that the axes of the holes intersect so that jets of fluids generated by the holes impinge with each other.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 20, 2014
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Stephen Terence DUNNE
  • Patent number: 8669109
    Abstract: A new method for selecting clones and recloning mammalian cells which are of importance for the production of biopharmaceuticals, preferably hamster or mouse myeloma cells, with a high degree of automation and throughput. The invention relates to methods of depositing and replicating single cell clones of the cells in question. The invention also relates to methods of preparing proteins using cells which have been obtained and replicated by single cell deposition as well as compositions which allow the replication of single cells.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: March 11, 2014
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ralf Otto, Barbara Enenkel, Juergen Fieder, Thomas Krieg
  • Patent number: 8664232
    Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: March 4, 2014
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Michael Mark, Roland Maier, Ralf R. H. Lotz, Mohammad Tadayyon