Patents Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG
  • CGRP Antagonists
    Publication number: 20100152171
    Abstract: CGRP antagonists of the formula of which the following are exemplary: (1) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide, (2) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-amide.
    Type: Application
    Filed: February 17, 2010
    Publication date: June 17, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Klaus RUDOLF, Stephan Georg MUELLER, Dirk STENKAMP, Philipp LUSTENBERGER, Alexander DREYER, Eckhart BAUER, Marcus SCHINDLER, Kirsten ARNDT, Henri DOODS
  • HFA supension formulations containing an anticholinergic
    Patent number: 7736626
    Abstract: The invention relates to propellant gas formulations containing suspensions of the crystalline monohydrate of (1?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: June 15, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Christel Schmelzer
  • HFA suspension formulations containing an anticholinergic
    Patent number: 7736627
    Abstract: The invention relates to propellant gas formulations containing suspensions of the crystalline monohydrate of (1?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: June 15, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Christel Schmelzer
  • XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
    Publication number: 20100144703
    Abstract: Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: February 17, 2010
    Publication date: June 10, 2010
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank HIMMELSBACH, Elke LANGKOPF, Matthias ECKHARDT, Roland MAIER, Michael MARK, Mohammad TADAYYON, Ralf R. H. LOTZ
  • METHOD FOR MIXING POWDERS
    Publication number: 20100143331
    Abstract: The invention relates to a method for preparing powder mixtures, one component consisting of spray-dried powder. The invention also relates to a method for coating spray-dried particles with nanoscale particles, a method for mixing spray-dried powder with microscale particles and a method for covering carrier substances with spray-dried particles.
    Type: Application
    Filed: November 8, 2007
    Publication date: June 10, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Torsten Schultz-Fademrecht, Sandra Zimontkowski, Patrick Garidel, Hans-Joachim Kern, Klaus-Juergen Steffens
  • NEW POLYMORPHS OF ETHYL 3-[(2-{[4-(HEXYLOXYCARBONYLAMINO-IMINO- METHYL)-PHENYLAMINO]-METHYL-1-METHYL-1H-BENZIMIDAZOLE-5-CARBONYL) -PYRIDIN-2-YL-AMINO]-PROPIONATE
    Publication number: 20100144796
    Abstract: The invention relates to new polymorphs of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate, the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: November 15, 2007
    Publication date: June 10, 2010
    Applicant: Boehringer Ingelheim Pharma GMBH & CO.KG
    Inventors: Mihaela Pop, Jaroslaw Mazurek, Mimoun Lamkadmi
  • USE OF INHIBITORS OF THE EGFR-MEDIATED SIGNAL TRANSDUCTION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA (BPH) / PROSTATIC HYPERTROPHY
    Publication number: 20100144639
    Abstract: The present invention relates to the use of specific EGF-receptor antagonists for preparing a pharmaceutical composition for the prevention and/or treatment of benign prostatic hyperplasia and/or prostatic hypertrophy, a method for the treatment or prevention of benign prostatic hyperplasia/prostatic hypertrophy comprising administering an EGF-receptor antagonist of groups (A), (B) or (C), described herein optionally in combination with known compounds for the treatment of benign prostatic hyperplasia/prostatic hypertrophy, as well as associated pharmaceutical compositions.
    Type: Application
    Filed: February 17, 2010
    Publication date: June 10, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Thomas SINGER, Stefan PLATZ, Florian COLBATZKY
  • Neomycin-phosphotransferase-genes and methods for the selection of recombinant cells producing high levels of a desired gene product
    Patent number: 7732181
    Abstract: The invention relates to modified neomycin phosphotransferase genes and their use in a selection method for high-producing recombinant cells. The invention further relates to expression vectors which contain a modified neomycin phosphotransferase gene and a gene of interest functionally linked to a heterologous promoter and a method of preparing heterologous gene products using these expression vectors.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: June 8, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Barbara Enenkel, Juergen Fieder, Ralf Otto, Kerstin Sautter, Klaus Bergemann
  • Method and Device for Cleaning an Absorptive Polyester
    Publication number: 20100137550
    Abstract: In a method for cleaning an absorptive polyester, the polymer is dissolved in a first solvent (12) and subsequently the polymer solution is brought into tight contact with a second solvent (41) in a turbulent shear field under the influence of strong shear forces. Here, the second solvent (41) represents a non-solvent for the absorptive polyester and is mixable with the first solvent (12) to an unlimited extent. Subsequently, the polymer suspension resulting from the addition of the second solvent (41) is conveyed onto or into a rotating, cylindrical screen body (71) of a drum shear screen (70) and then the moist polymer mass is removed from the screen body (71) and subsequently dried. The method is suitable for the production of absorptive polyester with a high degree of quality and may be performed in a cost-effective fashion on an industrial scale as well.
    Type: Application
    Filed: May 2, 2008
    Publication date: June 3, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Anja Enderle, Manfred Schmitt
  • Powder comprising new compositions of oligosaccharides and methods for their preparation
    Patent number: 7727962
    Abstract: The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: June 1, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Medicaments for the treatment of chronic obstructive pulmonary disease
    Patent number: 7727984
    Abstract: A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: June 1, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf
  • Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
    Patent number: 7723306
    Abstract: The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: May 25, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Computer-implemented methods for evaluating, summarizing and presenting data on stability of drug substances and drug products and software-modified computers for such methods
    Publication number: 20100125434
    Abstract: Computer-implemented methods for statistical analysis and summarization of a stability study on a pharmaceutical product using of a macro integrated into statistical analysis software. The method includes inputting and summarizing data observed for a stability study on a pharmaceutical product, statistically analyzing the data, including using at least one regression function to characterize the time-response relationship of at least one stability response variable, to estimate a shelf life of the pharmaceutical product or confirm the shelf life of an existing pharmaceutical product, and providing standardized output data and graphical presentations of observed stability response data. Also, a computer loaded with a general statistical analysis software and a macro integrated with the software such that the computer is capable of performing these computer-implemented methods using the software and macro.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 20, 2010
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rene Kubiak, James Schwenke, Volker Kryzkalla, Hans-Juergen Lomp, Cornelia Schepers
  • Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
    Publication number: 20100113411
    Abstract: The present invention relates to CGRP antagonists of general formula wherein A, U, V, W, X and R1 to R3 are defined as in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures thereof and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.
    Type: Application
    Filed: August 6, 2009
    Publication date: May 6, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Klaus RUDOLF, Stephan Georg MUELLER, Dirk STENKAMP, Philipp LUSTENBERGER, Alexander DREYER, Eckhart BAUER, Marcus SCHINDLER, Kirsten ARNDT, Henri DOODS
  • Dry powder inhaler
    Patent number: 7708011
    Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: May 4, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH and Co. KG
    Inventors: Dieter Hochrainer, Joerg Schiewe, Bernd Zierenberg, Stephen Dunne
  • Pyrimidine derivatives
    Patent number: 7709480
    Abstract: The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: May 4, 2010
    Assignees: Boehringer Ingelheim Pharma GmbH & Co. KG, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Georg Dahmann, Frank Himmelsbach, Bernd Krist, Martin Lenter, Alexander Pautsch, Gisela Schapp, Martin Steegmaier, Helmut Wittneben, Anthony S. Prokopowicz, Walter Spevak, Andreas Schoop, Steffen Steurer
  • METHOD FOR PRODUCING SCOPINIUM SALTS
    Publication number: 20100105898
    Abstract: The invention relates to a new method of preparing scopinium salts of general formula 1 wherein Y? may have the meanings given in the claims and in the specification.
    Type: Application
    Filed: January 28, 2008
    Publication date: April 29, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Joerg Brandenburg, Werner Belzer
  • Apparatus For The Dispensing Of Liquids, Container Cartridge Suitable For This, And System Comprising The Apparatus For The Dispensing Of Liquids And The Container Cartridge
    Publication number: 20100096408
    Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.
    Type: Application
    Filed: December 22, 2009
    Publication date: April 22, 2010
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Schiewe, Gilbert Wuttke, Bernd Zierenberg, Stephen Dunne, Horst Wergen
  • CGRP antagonists
    Patent number: 7700589
    Abstract: CGRP antagonists of the formula of which the following are exemplary: (1) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide, (2) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-amide.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Klaus Rudolf, Stephan Georg Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Eckhart Bauer, Marcus Schindler, Kirsten Arndt, Henri Doods
  • Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids, and the container cartridge
    Patent number: 7699052
    Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: April 20, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Schiewe, Gilbert Wuttke, Bernd Zierenberg, Stephen Dunne, Horst Wergen