Patents Assigned to Bracco Imaging S.p.A.
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Publication number: 20210395832Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.Type: ApplicationFiled: November 8, 2019Publication date: December 23, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Andrea FERRARIS, Erika REITANO, Alessandro MAIOCCHI
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Publication number: 20210292762Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.Type: ApplicationFiled: July 24, 2019Publication date: September 23, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Vittorio DE FRANCISCIS, Silvia CATUOGNO, Carla Lucia ESPOSITO, Alessandro MAIOCCHI, Margherita IABONI, Luisa POGGI, Erika REITANO
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Publication number: 20210263122Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.Type: ApplicationFiled: April 30, 2021Publication date: August 26, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
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Publication number: 20210196840Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.Type: ApplicationFiled: March 11, 2021Publication date: July 1, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
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Patent number: 11021451Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: June 30, 2020Date of Patent: June 1, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Patent number: 11014942Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.Type: GrantFiled: November 8, 2019Date of Patent: May 25, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
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Patent number: 11007283Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: April 5, 2017Date of Patent: May 18, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Patent number: 10973934Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.Type: GrantFiled: August 6, 2019Date of Patent: April 13, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Napolitano, Luciano Lattuada, Zsolt Baranyai, Nicole Guidolin, Giuseppe Marazzi
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Publication number: 20210024500Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: October 1, 2020Publication date: January 28, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
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Patent number: 10882849Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: July 25, 2019Date of Patent: January 5, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
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Publication number: 20200376145Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.Type: ApplicationFiled: August 6, 2019Publication date: December 3, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
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Publication number: 20200379070Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.Type: ApplicationFiled: December 22, 2016Publication date: December 3, 2020Applicant: Bracco Imaging S.p.A.Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
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Patent number: 10822371Abstract: The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.Type: GrantFiled: December 5, 2018Date of Patent: November 3, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Raphael Campanella, Anthony Clouet, Luciano Lattuada
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Publication number: 20200331893Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: July 25, 2019Publication date: October 22, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
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Publication number: 20200325108Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: June 30, 2020Publication date: October 15, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
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Publication number: 20200317722Abstract: The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.Type: ApplicationFiled: December 5, 2018Publication date: October 8, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Raphael CAMPANELLA, Anthony CLOUET, Luciano LATTUADA
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Patent number: 10793533Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: December 11, 2017Date of Patent: October 6, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
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Patent number: 10781188Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: December 12, 2016Date of Patent: September 22, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Patent number: 10780184Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.Type: GrantFiled: January 31, 2019Date of Patent: September 22, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Simona Ghiani, Alessandro Maiocchi, Lara Caminiti, Luigi Miragoli
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Patent number: 10695448Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.Type: GrantFiled: June 17, 2019Date of Patent: June 30, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Silvio Aime, Tommaso Boi, Erika Cerutti, Francesca Reineri