Abstract: Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
Abstract: Thin-film photovoltaic devices and methods of their use and manufacture are disclosed. More particularly, polycrystalline CuIn(1-x)GaxSe2 (CIGS) based thin-film photovoltaic devices having independently tunable sublayers are disclosed. Also provided are methods of producing an n-doped graphene.
Type:
Application
Filed:
March 20, 2015
Publication date:
April 20, 2017
Applicants:
Brookhaven Science Associates, LLC, The Research Foundation for The State University of New York, The Research Foundation for The State University of New York
Inventors:
Nanditha Dissanayake, Matthew Eisaman, Ahsan Ashraf, Nancy Goroff, Xiuzhu Ang
Abstract: In the tgd1-1 mutant that displays substantially enhanced TAG synthesis and turnover, disruption of SUGAR-DEPENDENT1 (SDP1) TAG lipase or PEROXISOMAL TRANSPORTER1 (PXA1) severely decreases FA turnover, leading to an increase in leaf TAG content up to 9% of dry weight and total leaf lipid by three-fold. The membrane lipid content and composition of tgd1-1 sdp1-4 and tgd1-1 pxa1-2 double mutants are altered and they are compromised in growth and development and fertility.
Type:
Grant
Filed:
July 2, 2015
Date of Patent:
March 14, 2017
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Changcheng Xu, Jilian Fan, Chengshi Yan, John Shanklin
Abstract: A catalytic composition from earth-abundant transition metal salts and biomass is disclosed. A calcined catalytic composition formed from soybean powder and ammonium molybdate is specifically exemplified herein. Methods for making the catalytic composition are disclosed as are electrodes for hydrogen evolution reactions comprising the catalytic composition.
Type:
Grant
Filed:
October 1, 2013
Date of Patent:
February 28, 2017
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Wei-Fu Chen, Shweta Iyer, Shilpa Iyer, Kotaro Sasaki, James T. Muckerman, Etsuko Fujita
Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.
Type:
Application
Filed:
October 31, 2016
Publication date:
February 16, 2017
Applicants:
Brookhaven Science Associates, LLC, UChicago Argonne, LLC, The Research Foundation for the State University of New York
Inventors:
Anirudha V. Sumant, John Smedley, Erik Muller
Abstract: This disclosure describes hydrophobic or super-hydrophobic compositions, such as sponges, that also are oleophilic or super-oleophilic with superior recyclability, good mechanical strength, low cost, and manufacture scalability. The hydrophobic or super-hydrophobic compositions include the reaction product of at least a substrate having a reacting group which reacts with a silane and an alkylsilane or a fluoroalkylsilane having an alkyl group comprised of a hydrocarbon, an aliphatic hydrocarbon, or a fluorohydrocarbon of 1 to about 30 carbon atoms.
Abstract: Specialized (iso)eugenol 4-O-methyltransferase (s-IEMT) enzymes having increased capacity for methylation of monolignols are disclosed. The s-IEMTs have unique activity favoring methylation of coniferyl alcohol versus sinapyl alcohol. Various s-IEMTs methylate ferulic acid. Means for producing the various s-IEMTs are provided. The s-IEMTs are useful for modification of lignin content and production of aromatic compounds.
Abstract: A nano-confinement platform that may allow improved quantification of the structural order of nanometer-scale systems. Sample-holder ‘chips’ are designed for the GTSAXS experimental geometry. The platform involves fabricated nanostructured sample holders on and in one or more corners of a substrate support where the sample material of interest is positioned at the corner of the substrate support. In an embodiment, the substrate material making up the substrate support beneath the sample-holding area is removed. A scattering x-ray sample platform includes a substrate support arranged in a parallelepiped form, having a substantially flat base and a substantially flat top surface, the top surface being substantially parallel with the base, the parallelepiped having a plurality of corners. At least one corner of the substrate support has a sample holding area formed in the top surface of the substrate support and within a predetermined distance from the corner.
Abstract: This disclosure relates to apparatuses and methods for the extraction of particle beams while maintaining the energy levels and precision of the particles and the particle beam. Apparatuses and methods for extracting a charged particle beam from a central orbit in a synchrotron are provided, in which a particle beam is deflected from the central orbit. Parts of the deflected particle beam passes through a stripping foil placed in at least parts of the deflected path such that the particles that pass through the foil are stripped of at least one electron. The electron stripped particles and the non-stripped particles may be separated magnetically.
Abstract: A method and apparatus for a current-output peak detector. A current-output peak detector circuit is disclosed and works in two phases. The peak detector circuit includes switches to switch the peak detector circuit from the first phase to the second phase upon detection of the peak voltage of an input voltage signal. The peak detector generates a current output with a high degree of accuracy in the second phase.
Abstract: A method of synthesizing activated electrocatalyst, preferably having a morphology of a nanostructure, is disclosed. The method includes safely and efficiently removing surfactants and capping agents from the surface of the metal structures. With regard to metal nanoparticles, the method includes synthesis of nanoparticle(s) in polar or non-polar solution with surfactants or capping agents and subsequent activation by CO-adsorption-induced surfactant/capping agent desorption and electrochemical oxidation. The method produces activated macroparticle or nanoparticle electrocatalysts without damaging the surface of the electrocatalyst that includes breaking, increasing particle thickness or increasing the number of low coordination sites.
Type:
Grant
Filed:
January 7, 2013
Date of Patent:
November 8, 2016
Assignees:
Brookhaven Science Associates, LLC, The Research Foundation for the State University of New York
Inventors:
Radoslav R. Adzic, Kuanping Gong, Yun Cai, Stanislaus Wong, Christopher Koenigsmann
Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.
Type:
Grant
Filed:
July 2, 2015
Date of Patent:
November 1, 2016
Assignees:
UChicago Argonne, LLC, Brookhaven Science Associates, LLC, The Research Foundation for the State University of New York
Inventors:
Anirudha V. Sumant, John Smedley, Erik Muller
Abstract: Technologies are described effective to implement systems and methods of producing a material. The methods comprise receiving a tertiary semiconductor sample with a dilute species. The sample has two ends. The first end of the sample includes a first concentration of the dilute species lower than a second concentration of the dilute species in the second end of the sample. The method further comprises heating the sample in a chamber. The chamber has a first zone and a second zone. The first zone having a first temperature higher than a second temperature in the second zone. The sample is orientated such that the first end is in the first zone and the second end is in the second zone.
Type:
Grant
Filed:
October 25, 2013
Date of Patent:
September 6, 2016
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Ralph B. James, Giuseppe Camarda, Aleksey E. Bolotnikov, Anwar Hossain, Ge Yang, Kihyun Kim
Abstract: A method for fabricating monolayer graphene-boron nitride heterostructures in a single atomically thin membrane that limits intermixing at boundaries between graphene and h-BN, so as to achieve atomically sharp interfaces between these materials. In one embodiment, the method comprises exposing a ruthenium substrate to ethylene, exposing the ruthenium substrate to oxygen after exposure to ethylene and exposing the ruthenium substrate to borazine after exposure to oxygen.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
August 9, 2016
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Peter Werner Sutter, Eli Anguelova Sutter
Abstract: Heterologous expression of E. coli cyclopropane synthase in genotypic and phenotypic fad2fae1 plants facilitates accumulation of cyclopropane fatty acids. Co-expression of Sterculia foetida transferases, including lysophosphatidic acid acyltransferase, diacylglycerol acyltransferase (DGAT), and Phospholipid Diacyl Glycerol Acyltransferase (PDAT), with E. coli cyclopropane synthase further enhances cyclopropane fatty acid accumulation in fad2fae1 plant seeds.
Type:
Application
Filed:
August 26, 2014
Publication date:
August 4, 2016
Applicant:
Brookhaven Science Associates, LLC
Inventors:
John Shanklin, Xiao-Hong Yu, Richa Rawat Prakash
Abstract: A parallel plate dimensional electrical mobility separator and laminar flow water condensation provide rapid, mobility-based particle sizing at concentrations typical of the remote atmosphere. Particles are separated spatially within the electrical mobility separator, enlarged through water condensation, and imaged onto a CCD array. The mobility separation distributes particles in accordance with their size. The condensation enlarges size-separated particles by water condensation while they are still within the gap of the mobility drift tube. Once enlarged the particles are illuminated by a laser. At a pre-selected frequency, typically 10 Hz, the position of all of the individual particles illuminated by the laser are captured by CCD camera. This instantly records the particle number concentration at each position. Because the position is directly related to the particle size (or mobility), the particle size spectra is derived from the images recorded by the CCD.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
July 19, 2016
Assignee:
BROOKHAVEN SCIENCE ASSOCIATES, LLC
Inventors:
Jian Wang, Susanne Vera Hering, Steven Russel Spielman, Chongai Kuang
Abstract: A drift detector array, preferably a silicon drift detector (SDD) array, that uses a low current biasing adaptor is disclosed. The biasing adaptor is customizable for any desired geometry of the drift detector single cell with minimum drift time of carriers. The biasing adaptor has spiral shaped ion-implants that generate the desired voltage profile. The biasing adaptor can be processed on the same wafer as the drift detector array and only one biasing adaptor chip/side is needed for one drift detector array to generate the voltage profiles on the front side and back side of the detector array.
Abstract: A long-range method and a system for reliably detecting and identifying special nuclear materials is provided that relies on the emission of delayed neutrons present in the decay of fission products (delayed neutron precursors) as a unique signature for the special nuclear materials, such as highly enriched uranium (235/238U). The method relies on a time-of-flight measurement in the first 1 ?s after the inducing radiation pulse, and pulse height data analysis for both neutrons and gamma rays that can be done at a much higher data rate than in traditional pulse processing systems. The thermal neutron fission within the time regime of 100-500 ?s provides a unique signature of special nuclear materials such as the highly enriched uranium.
Type:
Application
Filed:
February 4, 2016
Publication date:
June 30, 2016
Applicant:
Brookhaven Science Associates, LLC
Inventors:
Istvan Dioszegi, Leon Forman, Peter E. Vanier, Cynthia A. Salwen
Abstract: This disclosure provides embodiments of photovoltaic devices. The devices include a light-absorbing anode comprised of an electrically conductive material having a plasmonic structure, a diffusion barrier, and a cathode. The light-absorbing anode and the cathode are separated by the diffusion barrier.