Patents Assigned to Brookhaven Science Associates
  • Patent number: 9670258
    Abstract: Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: June 6, 2017
    Assignees: Ferring B.V., Brookhaven Science Associates, LLC
    Inventors: Paul O. Zamora, Louis A. Pena, Xinhua Lin, Takahashi Kazuyuki
  • Publication number: 20170110616
    Abstract: Thin-film photovoltaic devices and methods of their use and manufacture are disclosed. More particularly, polycrystalline CuIn(1-x)GaxSe2 (CIGS) based thin-film photovoltaic devices having independently tunable sublayers are disclosed. Also provided are methods of producing an n-doped graphene.
    Type: Application
    Filed: March 20, 2015
    Publication date: April 20, 2017
    Applicants: Brookhaven Science Associates, LLC, The Research Foundation for The State University of New York, The Research Foundation for The State University of New York
    Inventors: Nanditha Dissanayake, Matthew Eisaman, Ahsan Ashraf, Nancy Goroff, Xiuzhu Ang
  • Patent number: 9593344
    Abstract: In the tgd1-1 mutant that displays substantially enhanced TAG synthesis and turnover, disruption of SUGAR-DEPENDENT1 (SDP1) TAG lipase or PEROXISOMAL TRANSPORTER1 (PXA1) severely decreases FA turnover, leading to an increase in leaf TAG content up to 9% of dry weight and total leaf lipid by three-fold. The membrane lipid content and composition of tgd1-1 sdp1-4 and tgd1-1 pxa1-2 double mutants are altered and they are compromised in growth and development and fertility.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 14, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Changcheng Xu, Jilian Fan, Chengshi Yan, John Shanklin
  • Patent number: 9580823
    Abstract: A catalytic composition from earth-abundant transition metal salts and biomass is disclosed. A calcined catalytic composition formed from soybean powder and ammonium molybdate is specifically exemplified herein. Methods for making the catalytic composition are disclosed as are electrodes for hydrogen evolution reactions comprising the catalytic composition.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: February 28, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Wei-Fu Chen, Shweta Iyer, Shilpa Iyer, Kotaro Sasaki, James T. Muckerman, Etsuko Fujita
  • Publication number: 20170047468
    Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.
    Type: Application
    Filed: October 31, 2016
    Publication date: February 16, 2017
    Applicants: Brookhaven Science Associates, LLC, UChicago Argonne, LLC, The Research Foundation for the State University of New York
    Inventors: Anirudha V. Sumant, John Smedley, Erik Muller
  • Publication number: 20170036190
    Abstract: This disclosure describes hydrophobic or super-hydrophobic compositions, such as sponges, that also are oleophilic or super-oleophilic with superior recyclability, good mechanical strength, low cost, and manufacture scalability. The hydrophobic or super-hydrophobic compositions include the reaction product of at least a substrate having a reacting group which reacts with a silane and an alkylsilane or a fluoroalkylsilane having an alkyl group comprised of a hydrocarbon, an aliphatic hydrocarbon, or a fluorohydrocarbon of 1 to about 30 carbon atoms.
    Type: Application
    Filed: April 15, 2015
    Publication date: February 9, 2017
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: VIET HUNG PHAM, JAMES HENRY DICKERSON
  • Patent number: 9556420
    Abstract: Specialized (iso)eugenol 4-O-methyltransferase (s-IEMT) enzymes having increased capacity for methylation of monolignols are disclosed. The s-IEMTs have unique activity favoring methylation of coniferyl alcohol versus sinapyl alcohol. Various s-IEMTs methylate ferulic acid. Means for producing the various s-IEMTs are provided. The s-IEMTs are useful for modification of lignin content and production of aromatic compounds.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 31, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Chang-Jun Liu, Yuanheng Cai
  • Patent number: 9557283
    Abstract: A nano-confinement platform that may allow improved quantification of the structural order of nanometer-scale systems. Sample-holder ‘chips’ are designed for the GTSAXS experimental geometry. The platform involves fabricated nanostructured sample holders on and in one or more corners of a substrate support where the sample material of interest is positioned at the corner of the substrate support. In an embodiment, the substrate material making up the substrate support beneath the sample-holding area is removed. A scattering x-ray sample platform includes a substrate support arranged in a parallelepiped form, having a substantially flat base and a substantially flat top surface, the top surface being substantially parallel with the base, the parallelepiped having a plurality of corners. At least one corner of the substrate support has a sample holding area formed in the top surface of the substrate support and within a predetermined distance from the corner.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: January 31, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Charles T. Black, Kevin G. Yager
  • Patent number: 9550077
    Abstract: This disclosure relates to apparatuses and methods for the extraction of particle beams while maintaining the energy levels and precision of the particles and the particle beam. Apparatuses and methods for extracting a charged particle beam from a central orbit in a synchrotron are provided, in which a particle beam is deflected from the central orbit. Parts of the deflected particle beam passes through a stripping foil placed in at least parts of the deflected path such that the particles that pass through the foil are stripped of at least one electron. The electron stripped particles and the non-stripped particles may be separated magnetically.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: January 24, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventor: Nicholaos Tsoupas
  • Patent number: 9551734
    Abstract: A method and apparatus for a current-output peak detector. A current-output peak detector circuit is disclosed and works in two phases. The peak detector circuit includes switches to switch the peak detector circuit from the first phase to the second phase upon detection of the peak voltage of an input voltage signal. The peak detector generates a current output with a high degree of accuracy in the second phase.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: January 24, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventor: Gianluigi De Geronimo
  • Patent number: 9490486
    Abstract: A method of synthesizing activated electrocatalyst, preferably having a morphology of a nanostructure, is disclosed. The method includes safely and efficiently removing surfactants and capping agents from the surface of the metal structures. With regard to metal nanoparticles, the method includes synthesis of nanoparticle(s) in polar or non-polar solution with surfactants or capping agents and subsequent activation by CO-adsorption-induced surfactant/capping agent desorption and electrochemical oxidation. The method produces activated macroparticle or nanoparticle electrocatalysts without damaging the surface of the electrocatalyst that includes breaking, increasing particle thickness or increasing the number of low coordination sites.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: November 8, 2016
    Assignees: Brookhaven Science Associates, LLC, The Research Foundation for the State University of New York
    Inventors: Radoslav R. Adzic, Kuanping Gong, Yun Cai, Stanislaus Wong, Christopher Koenigsmann
  • Patent number: 9484474
    Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: November 1, 2016
    Assignees: UChicago Argonne, LLC, Brookhaven Science Associates, LLC, The Research Foundation for the State University of New York
    Inventors: Anirudha V. Sumant, John Smedley, Erik Muller
  • Patent number: 9437692
    Abstract: Technologies are described effective to implement systems and methods of producing a material. The methods comprise receiving a tertiary semiconductor sample with a dilute species. The sample has two ends. The first end of the sample includes a first concentration of the dilute species lower than a second concentration of the dilute species in the second end of the sample. The method further comprises heating the sample in a chamber. The chamber has a first zone and a second zone. The first zone having a first temperature higher than a second temperature in the second zone. The sample is orientated such that the first end is in the first zone and the second end is in the second zone.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: September 6, 2016
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Ralph B. James, Giuseppe Camarda, Aleksey E. Bolotnikov, Anwar Hossain, Ge Yang, Kihyun Kim
  • Patent number: 9410243
    Abstract: A method for fabricating monolayer graphene-boron nitride heterostructures in a single atomically thin membrane that limits intermixing at boundaries between graphene and h-BN, so as to achieve atomically sharp interfaces between these materials. In one embodiment, the method comprises exposing a ruthenium substrate to ethylene, exposing the ruthenium substrate to oxygen after exposure to ethylene and exposing the ruthenium substrate to borazine after exposure to oxygen.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: August 9, 2016
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Peter Werner Sutter, Eli Anguelova Sutter
  • Publication number: 20160222398
    Abstract: Heterologous expression of E. coli cyclopropane synthase in genotypic and phenotypic fad2fae1 plants facilitates accumulation of cyclopropane fatty acids. Co-expression of Sterculia foetida transferases, including lysophosphatidic acid acyltransferase, diacylglycerol acyltransferase (DGAT), and Phospholipid Diacyl Glycerol Acyltransferase (PDAT), with E. coli cyclopropane synthase further enhances cyclopropane fatty acid accumulation in fad2fae1 plant seeds.
    Type: Application
    Filed: August 26, 2014
    Publication date: August 4, 2016
    Applicant: Brookhaven Science Associates, LLC
    Inventors: John Shanklin, Xiao-Hong Yu, Richa Rawat Prakash
  • Patent number: 9395281
    Abstract: A parallel plate dimensional electrical mobility separator and laminar flow water condensation provide rapid, mobility-based particle sizing at concentrations typical of the remote atmosphere. Particles are separated spatially within the electrical mobility separator, enlarged through water condensation, and imaged onto a CCD array. The mobility separation distributes particles in accordance with their size. The condensation enlarges size-separated particles by water condensation while they are still within the gap of the mobility drift tube. Once enlarged the particles are illuminated by a laser. At a pre-selected frequency, typically 10 Hz, the position of all of the individual particles illuminated by the laser are captured by CCD camera. This instantly records the particle number concentration at each position. Because the position is directly related to the particle size (or mobility), the particle size spectra is derived from the images recorded by the CCD.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: July 19, 2016
    Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Jian Wang, Susanne Vera Hering, Steven Russel Spielman, Chongai Kuang
  • Publication number: 20160201069
    Abstract: The present disclosure provides methods and compositions for genetic transformation of Lemnaceae species.
    Type: Application
    Filed: August 21, 2014
    Publication date: July 14, 2016
    Applicants: Cold Spring Harbor Laboratory, Brookhaven Science Associates, LLC
    Inventors: Rob Martienssen, Almudena Molla-Morales, Cantó Pastor Alex, Evan Ernst, John Shanklin, Yihen Yan
  • Patent number: 9383452
    Abstract: A drift detector array, preferably a silicon drift detector (SDD) array, that uses a low current biasing adaptor is disclosed. The biasing adaptor is customizable for any desired geometry of the drift detector single cell with minimum drift time of carriers. The biasing adaptor has spiral shaped ion-implants that generate the desired voltage profile. The biasing adaptor can be processed on the same wafer as the drift detector array and only one biasing adaptor chip/side is needed for one drift detector array to generate the voltage profiles on the front side and back side of the detector array.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: July 5, 2016
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Zheng Li, Wei Chen
  • Publication number: 20160187270
    Abstract: A long-range method and a system for reliably detecting and identifying special nuclear materials is provided that relies on the emission of delayed neutrons present in the decay of fission products (delayed neutron precursors) as a unique signature for the special nuclear materials, such as highly enriched uranium (235/238U). The method relies on a time-of-flight measurement in the first 1 ?s after the inducing radiation pulse, and pulse height data analysis for both neutrons and gamma rays that can be done at a much higher data rate than in traditional pulse processing systems. The thermal neutron fission within the time regime of 100-500 ?s provides a unique signature of special nuclear materials such as the highly enriched uranium.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 30, 2016
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Istvan Dioszegi, Leon Forman, Peter E. Vanier, Cynthia A. Salwen
  • Publication number: 20160181449
    Abstract: This disclosure provides embodiments of photovoltaic devices. The devices include a light-absorbing anode comprised of an electrically conductive material having a plasmonic structure, a diffusion barrier, and a cathode. The light-absorbing anode and the cathode are separated by the diffusion barrier.
    Type: Application
    Filed: November 19, 2015
    Publication date: June 23, 2016
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Charles T. Black, Matthew Sfeir