Patents Assigned to Brown University
  • Patent number: 11461519
    Abstract: Methods and apparatus for extracting one or more mechanical properties for a material based on one or more indentation parameters for the material. The method comprises receiving load-displacement data from one or more instrumented indentation tests on the material, determining, by at least one computer processor, the indentation parameters for the material based, at least in part, on the received load-displacement data, providing as input to a trained neural network, the indentation parameters for the material, determining, based on an output of the trained neural network, the one or more mechanical properties of the material, and displaying an indication of the determined one or more mechanical properties of the material to a user of the computer system.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: October 4, 2022
    Assignees: Nanyang Technological University, Massachusetts Institute of Technology, Brown University
    Inventors: Lu Lu, Ming Dao, Subra Suresh, George Karniadakis
  • Patent number: 11430994
    Abstract: Double-layered protective coatings for lithium metal electrodes, as well as methods of formation relating thereto, are provided. The negative electrode assembly includes an electroactive material layer including lithium metal and a protective dual-layered coating. The protective dual-layered coating includes a polymeric layer disposed on a surface of the electroactive material layer and an inorganic layer disposed on an exposed surface of the polymeric layer. The polymeric layer has an elastic modulus of greater than or equal to about 0.01 GPa to less than or equal to about 410 GPa. The inorganic layer has an elastic modulus of greater than or equal to about 10 GPa to less than or equal to about 1000 GPa.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: August 30, 2022
    Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, BROWN UNIVERSITY
    Inventors: Xingcheng Xiao, Binsong Li, Huajian Gao, Kai Guo
  • Patent number: 11429105
    Abstract: A system for motion planning for autonomous vehicles can include a plurality of sensors, a plurality of detectors in electrical communication with the plurality of sensors, and a motion planning module in electrical communication with the plurality of detectors and a computing system of an autonomous vehicle. The motion planning module stores a planning graph with each node representing, explicitly or implicitly, time and variables defining a state of the autonomous vehicle, an operating environment, or both the state of the autonomous vehicle and the operating environment. A reconfigurable processor can include a collision detection module and, optionally, a shortest path module. Pre-computed collision data and planning graph data reflecting logical/physical node mapping can be communicated to the processor during a programming phase and used during runtime.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: August 30, 2022
    Assignees: DUKE UNIVERSITY, BROWN UNIVERSITY
    Inventors: Daniel J. Sorin, George D. Konidaris, William Floyd-Jones, Sean Murray
  • Patent number: 11425358
    Abstract: A system and method to capture the surface geometry a three-dimensional object in a scene using unsynchronized structured lighting is disclosed. The method and system includes a pattern projector configured and arranged to project a sequence of image patterns onto the scene at a pattern frame rate, a camera configured and arranged to capture a sequence of unsynchronized image patterns of the scene at an image capture rate, and a processor configured and arranged to synthesize a sequence of synchronized image frames from the unsynchronized image patterns of the scene. Each of the synchronized image frames corresponds to one image pattern of the sequence of image patterns.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: August 23, 2022
    Assignee: BROWN UNIVERSITY
    Inventors: Gabriel Taubin, Daniel Moreno, Fatih Calakli
  • Patent number: 11425356
    Abstract: A system and method to calibrate an uncollimated laser diode for three-dimensional imaging applications. A method includes providing an optical comparator having an uncollimated laser diode as a light source to generate a shadow with sharp boundaries when used to illuminate an opaque occluder, wherein a two lines source model of light propagation is used to describe a behavior of the uncollimated laser diode, the two lines source model defined by two three-dimensional (3D) lines as model parameters, the uncollimated laser diode calibrated by estimating the two lines as a function of a sample of a ray field emitted by the uncollimated laser diode.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: August 23, 2022
    Assignee: Brown University
    Inventors: Gabriel Taubin, Wook Yeon Hwang
  • Patent number: 11383386
    Abstract: A method includes providing a robot, providing an image of drawn handwritten characters to the robot, enabling the robot to capture a bitmapped image of the image of drawn handwritten characters, enabling the robot to infer a plan to replicate the image with a writing utensil, and enabling the robot to reproduce the image.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: July 12, 2022
    Assignee: Brown University
    Inventors: Stefanie Tellex, Atsunobu Kotani
  • Patent number: 11387420
    Abstract: An aspect of the present disclosure is a method that includes exchanging at least a portion of a first cation of a perovskite solid with a second cation, where the exchanging is performed by exposing the perovskite solid to a precursor of the second cation, such that the precursor of the second cation oxidizes to form the second cation and the first cation reduces to form a precursor of the first cation.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: July 12, 2022
    Assignees: Alliance for Sustainable Energy, LLC, Brown University
    Inventors: Kai Zhu, Mengjin Yang, Yuanyuan Zhou, Nitin P. Padture
  • Publication number: 20220207218
    Abstract: Methods and apparatus for extracting one or more mechanical properties for a material based on one or more indentation parameters for the material. The method comprises receiving load-displacement data from one or more instrumented indentation tests on the material, determining, by at least one computer processor, the indentation parameters for the material based, at least in part, on the received load-displacement data, providing as input to a trained neural network, the indentation parameters for the material, determining, based on an output of the trained neural network, the one or more mechanical properties of the material, and displaying an indication of the determined one or more mechanical properties of the material to a user of the computer system.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 30, 2022
    Applicants: Nanyang Technological University, Massachusetts Institute of Technology, Brown University
    Inventors: Lu Lu, Ming Dao, Subra Suresh, George Karniadakis
  • Patent number: 11374211
    Abstract: An energy storage composition can be used as a new Na-ion battery cathode material. The energy storage composition with an alluaudite phase of AxTy(PO4)z, NaxTy(PO4)z, Na1.702Fe3(PO4)3 and Na0.872Fe3(PO4)3, is described including the hydrothermal synthesis, crystal structure, and electrochemical properties. After ball milling and carbon coating, the compositions described herein demonstrate a reversible capacity, such as about 140.7 mAh/g. In addition these compositions exhibit good cycling performance (93% of the initial capacity is retained after 50 cycles) and excellent rate capability. These alluaudite compounds represent a new cathode material for large-scale battery applications that are earth-abundant and sustainable.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: June 28, 2022
    Assignee: BROWN UNIVERSITY
    Inventors: G. Tayhas R. Palmore, Dan Liu
  • Patent number: 11340616
    Abstract: A system for motion planning for autonomous vehicles can include a plurality of sensors, a plurality of detectors in electrical communication with the plurality of sensors, and a motion planning module in electrical communication with the plurality of detectors and a computing system of an autonomous vehicle. The motion planning module stores a planning graph with each node representing, explicitly or implicitly, time and variables defining a state of the autonomous vehicle, an operating environment, or both the state of the autonomous vehicle and the operating environment. A reconfigurable processor can include a collision detection module and, optionally, a shortest path module. Pre-computed collision data and planning graph data reflecting logical/physical node mapping can be communicated to the processor during a programming phase and used during runtime.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: May 24, 2022
    Assignees: DUKE UNIVERSITY, BROWN UNIVERSITY
    Inventors: Daniel J. Sorin, George D. Konidaris, William Floyd-Jones, Sean Murray
  • Patent number: 11330697
    Abstract: A laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target beam, a circulation pump within the flow system for circulating the liquid metal, a laser pulse emitter configured to transmit a plurality of laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target beam, the focusing optics directing the laser pulses to strike the metal target beam at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to allow the X-ray pulses to exit the chamber.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 10, 2022
    Assignees: Brown University, Research Instruments Corporation
    Inventor: Christoph Rose-Petruck
  • Patent number: 11324103
    Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 3, 2022
    Assignees: Research Instruments Corporation, Brown University
    Inventors: Daniel John DeCiccio, Christoph Rose-Petruck
  • Patent number: 11292456
    Abstract: A motion planner of an autonomous vehicle's computer system uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the vehicle prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the vehicle, the system sets a probability of collision with a dynamic object in the environment based at least in part on the collision assessment. Depending on whether the goal of the vehicle is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively high or relatively low potential of a collision with the particular dynamic object. The system then causes the actuator system of the vehicle to implement a motion plan with the applicable identified path based at least in part on the optimization.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 5, 2022
    Assignees: DUKE UNIVERSITY, BROWN UNIVERSITY
    Inventors: Daniel Sorin, William Floyd-Jones, Sean Murray, George Konidaris, William Walker
  • Patent number: 11286451
    Abstract: The invention provides a device and a method for the assembly of an aggregation of adherent cells, particularly a three-dimensional assembly of adherent cells.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: March 29, 2022
    Assignee: Brown University
    Inventors: Jeffrey R. Morgan, Kali L. Manning, Blanche Ip
  • Patent number: 11278527
    Abstract: Stress responses involve corticotropin releasing factor (CRF), the two cognate receptors (CRF1 and CRF2) and the CRF-binding protein (CRFBP). Utilizing a novel cell-based assay, a C-terminal CRFBP fragment [CRFBP(10 kD)] was found to potentiates CRF-intracellular Ca2+ release, demonstrating that CRFBP possesses excitatory roles in addition to the inhibitory role established by the N-terminal fragment of CRFBP [CRFBP(27 kD)]. This interaction was CRF2-specific, as CRF1 responses were not potentiated by CRFBP(10 kD). As there were currently no small molecule ligands available that selectively interact with either CRFBP or CRF2, a cell-based assay was miniaturized, wherein CRFBP(10 kD) was fused as a chimera with CRF2?, that allowed us to a perform a high-throughput screen (HTS) of approximately 350,000 small molecules.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: March 22, 2022
    Assignee: BROWN UNIVERSITY
    Inventor: Carolina L. Haass-Koffler
  • Patent number: 11273124
    Abstract: The invention provides functionalized antifungal-loaded liposomal formulations targeting Candida, which minimize damage to healthy human cells, limit antimicrobial exposure, and reduce the development of antifungal resistance.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: March 15, 2022
    Assignee: Brown University
    Inventors: Anita Shukla, Sarah Cowles, Noel Vera-Gonzalez, Christina Bailey-Hytholt, Eli Silvert
  • Patent number: 11242374
    Abstract: The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: February 8, 2022
    Assignees: Brown University, Central Michigan University
    Inventors: Christopher I. Moore, Ute Hochgeschwender, Diane Lipscombe
  • Patent number: 11219630
    Abstract: Described herein are methods of treating fibrosis and fibrotic diseases with certain aminoglycosides, e.g., kasugamycin derivatives thereof.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: January 11, 2022
    Assignee: Brown University
    Inventors: Jack A. Elias, Chun Geun Lee, Chang-Min Lee
  • Patent number: 11209178
    Abstract: A system passively cools, regulates humidity and/or rectifies diffusive transport of water vapor in an interior area within a structure. The system includes a membrane assembly covering a portion of the structure, wherein the membrane has an interior side facing the interior area and an exterior side. The membrane assembly defines a plurality of pores. When cooling, a supply of fluid is provided to the membrane assembly so that capillary action of the pores redistributes the fluid to create evaporation and, in turn, the desired heat flow. The membrane assembly can include an architectural membrane coated with a porous matrix coating to form the pores. A pump can provide the fluid to the interior side of the membrane assembly. Preferably, the architectural membrane is woven PTFE-coated fiberglass and the porous matrix coating is titanium dioxide, zeolites and/or silica gel.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: December 28, 2021
    Assignee: Brown University
    Inventor: Derek Martin Stein
  • Patent number: 11112261
    Abstract: According to some aspects, a wearable device for estimating a location of the device within a space is provided, the device comprising a plurality of cameras mounted to a structure, at least a portion of the structure being adapted to facilitate a user wearing the device, the plurality of cameras having substantially fixed positions and orientations on the structure relative to each other, and at least one processor configured to receive image data from the plurality of cameras, perform feature detection on the image data to obtain a first plurality of features from the image data, and determine an estimate of the location of the device in the space based, at least in part, on a location associated with a second plurality of features obtained from image data previously captured of the space that matches the first plurality of features.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: September 7, 2021
    Assignee: Brown University
    Inventor: Benjamin Kimia