Patents Assigned to Buddhist Tzu Chi Medical Foundation
  • Publication number: 20210301318
    Abstract: The present invention relates to a biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model for AS, an animal model produced therefrom, and a method for screening for an agent pharmaceutically active in the treatment of A S using such animal model.
    Type: Application
    Filed: July 10, 2019
    Publication date: September 30, 2021
    Applicants: ACADEMIA SINICA, BUDDHIST TZU CHI MEDICAL FOUNDATION, CHINA MEDICAL UNIVERSITY
    Inventors: Kuo-I LIN, Shih-Chieh HUNG, Chin-Hsiu LIU
  • Patent number: 11045264
    Abstract: The present invention provides a handheld robot for orthopedic surgery and a control method thereof. The handheld robot of the present invention includes a main body, a grip, a kinematic mechanism, a tool connector, a tool, a force sensor and a positioning unit. The handheld robot of the present invention combines the position/orientation information of the tool acquired by the positioning unit with the force/torque information acquired by the force sensor, and utilizes the combined information to adjust the position of the tool so as to keep the tool within the range/path of a predetermined operation plan. In this way, the precision of the orthopedic surgery can be enhanced, and the error occurred during the surgery can be minimized.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: June 29, 2021
    Assignees: NATIONAL TAIWAN UNIVERSITY, TAIPEI TZU CHI HOSPITAL, BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Ping-Lang Yen, Shuo-Suei Hung
  • Publication number: 20200261508
    Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.
    Type: Application
    Filed: March 17, 2020
    Publication date: August 20, 2020
    Applicant: Buddhist Tzu Chi Medical Foundation
    Inventors: Dah-Ching Ding, Kun-Chi Wu
  • Patent number: 10624928
    Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: April 21, 2020
    Assignee: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventors: Dah-Ching Ding, Kun-Chi Wu
  • Patent number: 10465167
    Abstract: An adjuvant for rapid proliferation of human mesenchymal stem cells in vitro is provided to overcome the problem of low cell amplification efficiency of human mesenchymal stem cells in a culture process. The adjuvant added for the culture of human mesenchymal stem cells includes at least one antioxidant, and a basic fibroblast growth factor (FGF-2). The adjuvant is added into a medium containing the human mesenchymal stem cells, and the culture takes place in a normal oxygen environment (21% oxygen tension), and the cells are divided rapidly, and the cell cycle at synthesis phase (S phase) percentage is increased to reduce ageing and improve differentiation potential. The adjuvant not only amplifies human mesenchymal stem cells rapidly to harvest the growth factor, but also maintains the characteristics of the multifunction of stem cells for the purposes of culturing and amplifying the human mesenchymal stem cells.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: November 5, 2019
    Assignee: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventors: Li-Yi Sun, Cheng-Yoong Pang, Ching-Feng Cheng, Dian-Kun Li
  • Publication number: 20190298664
    Abstract: This disclosure provides method and kit for myocardial reperfusion and method for attenuating or reducing myocardial reperfusion injury. By administering protein tyrosine phosphatases inhibitor or a protein tyrosine kinases activator, cardiac injury caused by ischemia/reperfusion will be attenuated or reduced.
    Type: Application
    Filed: March 28, 2019
    Publication date: October 3, 2019
    Applicants: Academia Sinica, Buddhist Tzu Chi Medical Foundation
    Inventors: Tzu-Ching Meng, Chiu-Fen Yang, Michael Yu-Chih Chen
  • Patent number: 9856454
    Abstract: A method for rapid mincing of adipose tissues to isolate live cells in vitro is disclosed to overcome the drawbacks of a lead procedure of isolating live cells by holding a knife to mince adipose tissues, which can only isolate a small number of live cells and obtain low cell viability. The method includes: providing an adipose tissue; mincing the adipose tissue homogeneously by a mincing device; adding a reagent into the minced adipose tissue to perform hydrolysis; performing centrifuge and isolation; and removing a supernatant to obtain a cell pellet. Therefore, the time of mincing adipose tissues can be shortened, and contaminations caused by repeated use of the knife can be avoided. The method can be used for isolating live cells of adipose tissues to improve the number of live cells per unit weight of adipose tissues without reducing the cell viability.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: January 2, 2018
    Assignee: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventors: Li-Yi Sun, Dian-Kun Li, Cheng-Yoong Pang, Yao-Jen Chang
  • Patent number: 9574175
    Abstract: An endometrial polyp stem cell is disclosed in the present invention. The endometrial polyp stem cell is isolated from an endometrial polyp tissue, expresses vimentin, CD13, CD29, CD44, and CD90, and has no expression of CD1q, CD3, CD34, and CD45.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: February 21, 2017
    Assignee: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventor: Dah-Ching Ding
  • Patent number: 9561082
    Abstract: The present invention provides a handheld robot for orthopedic surgery and a control method thereof. The handheld robot of the present invention includes a main body, a grip, a kinematic mechanism, a tool connector, a tool, a force sensor and a positioning unit. The handheld robot of the present invention combines the position/orientation information of the tool acquired by the positioning unit with the force/torque information acquired by the force sensor, and utilizes the combined information to adjust the position of the tool so as to keep the tool within the range/path of a predetermined operation plan. In this way, the precision of the orthopedic surgery can be enhanced, and the error occurred during the surgery can be minimized.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: February 7, 2017
    Assignees: NATIONAL TAIWAN UNIVERSITY, TAIPEI TZU CHI HOSPITAL, BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Ping-Lang Yen, Shuo-Suei Hung
  • Publication number: 20160355782
    Abstract: A method for enhancing differentiation of dopaminergic (DA) neurons is provided. The method of the present invention includes culturing precursor cells; administering urocortin to the precursor cells; and differentiating the precursor cells into the DA neurons.
    Type: Application
    Filed: June 8, 2015
    Publication date: December 8, 2016
    Applicant: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Mei-Jen Wang, Hsin-Yi Huang, Tsung-Lang Chiu, Hui-Fen Chang, Hui-Ru Hsu, Cheng-Yoong Pang, Hock-Kean Liew
  • Publication number: 20160095886
    Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.
    Type: Application
    Filed: May 11, 2015
    Publication date: April 7, 2016
    Applicant: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Dah-Ching Ding, Kun-Chi Wu
  • Publication number: 20150266945
    Abstract: A method of delivering antigenic peptide into the endoplasmic reticulum by the fusion protein includes: (a) preparing a fusion protein with a Tat-derived peptide, a (His)6 peptide, a ubiquitin, and an antigenic peptide provided in turn from the N-terminal end to the C-terminal end; (b) delivering the fusion protein across the cell membrane into the cytosol through the Tat-derived peptide; (c) cleaving the antigenic peptide from the fusion protein by cytosolic ubiquitin C-terminal hydrolases; and (d) transporting the antigenic peptide into the endoplasmic reticulum (ER) by a TAP1/2 transporter on the ER membrane.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 24, 2015
    Applicant: Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventors: Ning-Sheng LAI, Hsien-Bin HUANG, Hui-Chun YU
  • Publication number: 20150240210
    Abstract: A method for rapid mincing of adipose tissues to isolate live cells in vitro is disclosed to overcome the drawbacks of a lead procedure of isolating live cells by holding a knife to mince adipose tissues, which can only isolate a small number of live cells and obtain low cell viability. The method includes: providing an adipose tissue; mincing the adipose tissue homogeneously by a mincing device; adding a reagent into the minced adipose tissue to perform hydrolysis; performing centrifuge and isolation; and removing a supernatant to obtain a cell pellet. Therefore, the time of mincing adipose tissues can be shortened, and contaminations caused by repeated use of the knife can be avoided. The method can be used for isolating live cells of adipose tissues to improve the number of live cells per unit weight of adipose tissues without reducing the cell viability.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 27, 2015
    Applicant: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: LI-YI SUN, DIAN-KUN LI, CHENG-YOONG PANG, YAO-JEN CHANG
  • Publication number: 20150182285
    Abstract: The present invention provides a handheld robot for orthopedic surgery and a control method thereof. The handheld robot of the present invention includes a main body, a grip, a kinematic mechanism, a tool connector, a tool, a force sensor and a positioning unit. The handheld robot of the present invention combines the position/orientation information of the tool acquired by the positioning unit with the force/torque information acquired by the force sensor, and utilizes the combined information to adjust the position of the tool so as to keep the tool within the range/path of a predetermined operation plan. In this way, the precision of the orthopedic surgery can be enhanced, and the error occurred during the surgery can be minimized.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 2, 2015
    Applicants: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, NATIONAL TAIWAN UNIVERSITY
    Inventors: Ping-Lang YEN, Shuo-Suei HUNG
  • Publication number: 20150159137
    Abstract: An adjuvant for rapid proliferation of human mesenchymal stem cells in vitro is provided to overcome the problem of low cell amplification efficiency of human mesenchymal stem cells in a culture process. The adjuvant added for the culture of human mesenchymal stem cells includes at least one antioxidant, and a basic fibroblast growth factor (FGF-2). The adjuvant is added into a medium containing the human mesenchymal stem cells, and the culture takes place in a normal oxygen environment (21% oxygen tension), and the cells are divided rapidly, and the cell cycle at synthesis phase (S phase) percentage is increased to reduce ageing and improve differentiation potential. The adjuvant not only amplifies human mesenchymal stem cells rapidly to harvest the growth factor, but also maintains the characteristics of the multifunction of stem cells for the purposes of culturing and amplifying the human mesenchymal stem cells.
    Type: Application
    Filed: December 11, 2013
    Publication date: June 11, 2015
    Applicant: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: LI-YI SUN, CHENG-YOONG PANG, CHING-FENG CHENG, DIAN-KUN LI
  • Patent number: 8802630
    Abstract: A novel use of a neuropeptide for treating brain injury in a subject in need thereof is provided. The present invention also provides various amenable routes of administering urocortin, that is, via injection intracerebroventricularly and intraperitoneally, and via intravenous bolus administration.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: August 12, 2014
    Assignee: Buddhist Tzu Chi Medical Foundation
    Inventors: Cheng-Yoong Pang, Mei-Jen Wang, Hock Kean Liew, Hsin-Yi Huang, Chih-Wei Hsu, Jon-Son Kou, Ting-Yi Li, Hsiao-Fen Peng, Jia-Yi Wang