Patents Assigned to California Institute of Technology
  • Patent number: 10291894
    Abstract: Hardware and software methodology are described for three-dimensional imaging in connection with a single sensor. A plurality of images is captured at different degrees of focus without focus change of an objective lens between such images. Depth information is extracted by comparing image blur between the images captured on the single sensor.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: May 14, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Morteza Gharib, David Jeon
  • Patent number: 10290944
    Abstract: An integrated Multi-Port Driven (MPD) antenna that can be driven at many points with different signals. An integrated MPD radiating source utilizing an 8-phase ring oscillator and eight power amplifiers to drive the MPD antenna at 161 GHz with a total radiated power of ?2 dBm and a single element EIRP of 4.6 dBm has been demonstrated in silicon with single lobe well behaved radiation patterns closely matching simulation.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 14, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Steven Bowers, Seyed Ali Hajimiri
  • Patent number: 10287401
    Abstract: The present disclosure is directed to polymer and polymer conjugate-based nanoparticle delivery systems for delivering biological agents, and methods of making and using these compositions. Certain embodiments of the present disclosure provide polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) or Formula (II) or Formula (III): wherein is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: May 14, 2019
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Dorothy Pan
  • Patent number: 10287451
    Abstract: A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 14, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yu-Chong Tai, Dongyang Kang
  • Patent number: 10291030
    Abstract: A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom, and/or compactible structures and deployment mechanisms used to form and deploy such satellite modules and power generation tiles associated therewith are provided. Each satellite module and/or power generation tile may be formed of a compactable structure and deployment mechanism capable of reducing the payload area required to deliver the satellite module to an orbital formation within the space-based solar power station and reliably deploy it once in orbit.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: May 14, 2019
    Assignee: California Institute of Technology
    Inventors: Sergio Pellegrino, Harry A. Atwater, Seyed Ali Hajimiri, Manan Arya, Nicolas Lee, Melanie Delapierre
  • Patent number: 10285420
    Abstract: Ice nucleation and supercooling are controlled by the presence of magnetite particles. Magnetite decreases supercooling and promotes ice nucleation. Therefore, freezing of liquid solutions occurs at higher temperature compared to supercooled solutions. Applying a magnetic field allows control of supercooling and ice nucleation.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: May 14, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Atsuko Kobayashi, Joseph L. Kirschvink
  • Publication number: 20190125583
    Abstract: A device for irradiating ocular tissue, including a source of electromagnetic radiation; a beacon scattering the electromagnetic radiation transmitted through an opacity in ocular tissue so as to form scattered electromagnetic radiation; a modulator transmitting output electromagnetic radiation having a field determined from a recording of the scattered electromagnetic radiation transmitted through the opacity, so that the output electromagnetic radiation is transmitted through the opacity to the beacon. The device can be used to treat amblyopia or correct optical aberrations in corneal or lens tissue.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Applicant: California Institute of Technology
    Inventors: Lihong Wang, Frank L. Brodie, Yuecheng Shen, Yan Liu, Haowen Ruan
  • Publication number: 20190129206
    Abstract: An optical modulating device may include a plurality of quantum dot (QD)-containing layers having QDs and a plurality of refractive index change layers. The QD-containing layers may be disposed between the refractive index change layers, respectively. The optical modulating device may be configured to modulate light-emission characteristics of the plurality of QD-containing layers. At least two of the QD-containing layers may have different central emission wavelengths. At least two of the plurality of refractive index change layers may include different materials or have different carrier densities.
    Type: Application
    Filed: October 25, 2018
    Publication date: May 2, 2019
    Applicants: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Duhyun LEE, Ruzan SOKHOYAN, Yu-Jung LU, Ghazaleh KAFAIE SHIRMANESH, Harry ATWATER, Ragip PALA, Chanwook BAIK
  • Publication number: 20190131491
    Abstract: Provided are light emission devices including an output coupler and optical apparatuses having the same. The light emission device may include a QD layer containing quantum dots and a nano-antenna structure including an output coupler configured to control an output characteristic of light emitted from the QD layer. The output coupler may be configured to output an emission wavelength of the QD layer. The nano-antenna structure may include one of a metallic antenna, a dielectric antenna, and a slit-containing structure, or may have a multi-patch antenna structure or a fishbone antenna structure.
    Type: Application
    Filed: October 30, 2018
    Publication date: May 2, 2019
    Applicants: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Duhyun LEE, Ruzan SOKHOYAN, Yu-Jung LU, Ghazaleh KAFAIE SHIRMANESH, Harry A. ATWATER, Ragip A. PALA, Chan-Wook BAIK
  • Publication number: 20190126674
    Abstract: Systems and methods in accordance with embodiments of the invention implement flexible members that include integrated tools made from metallic glass-based materials. In one embodiment, a structure includes: a flexible member characterized by an elongated geometry and an integrated tool disposed at one end of the elongated geometry; where the flexible member includes a metallic glass-based material.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Applicant: California Institute of Technology
    Inventors: Aaron Parness, Kalind C. Carpenter, Douglas C. Hofmann
  • Patent number: 10276926
    Abstract: A deployable reflectarray antenna stowable in a 6U CubeSat volume is deployed through tape deployers and quartz cables. The telescoping waveguide is attached to the horn with a threaded insert. The reflectarray antenna has, at 37.75 GHz, a directivity of 48.5 dBi, a gain of 47.8 dBi, and an aperture efficiency of 42%. Hinges with a ball-end screw enable precise control of deployment angle of adjacent panels in the reflectarray antenna.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: April 30, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Thomas A. Cwik, Nacer E. Chahat, Jonathan Sauder, Manan Arya, Ellen Thiel
  • Publication number: 20190120743
    Abstract: The present disclosure describes a compact and lightweight, radial-flow DMA designed to operate at low aerosol and sheath flowrates (on the order of 0.3 L/min aerosol flow, and 0.6-1.2 L/min sheath flow) and so as to classify aerosols including particles having sizes in the 10-500 nm range. Thus, the DMA is capable of operating at relatively low resolution (RND=2-4) to minimize both instrument volume and pumping/power requirements, while enabling size distribution measurement with the precision required for desired applications.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 25, 2019
    Applicant: California Institute of Technology
    Inventors: Richard C. Flagan, Stavros Amanatidis, Changhyuk Kim
  • Patent number: 10266866
    Abstract: A method for preparing a methionine containing peptide or protein for analysis by mass spectrometry by incubating the methionine containing peptide or protein with a heterologous methionine sulfoxide reductase A (MsrA), a heterologous methionine sulfoxide reductase B (MsrB), or a heterologous methionine sulfoxide reductase AB (MsrAB) enzyme results in the reduction of an oxidized methionine containing peptide or protein.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: April 23, 2019
    Assignee: California Institute of Technology
    Inventors: Michael Sweredoski, Annie Moradian, Tanya R. Yakushi, Sonja Hess, Roxana Eggleston-Rangel
  • Patent number: 10267957
    Abstract: Structures for scattering light at multiple wavelengths are disclosed. Scattering elements are fabricated with different geometric dimensions and arrangements, to scatter or focus light at the same focal distance for each wavelength, or at different focal distances according to the desired application. The scattering elements fabricated on a substrate can be peeled off with a polymer matrix and attached to a lens to modify the optical properties of the lens.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: April 23, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Seyedeh Mahsa Kamali, Ehsan Arbabi, Amir Arbabi, Andrei Faraon
  • Patent number: 10267956
    Abstract: Structures for scattering light at multiple wavelengths are disclosed. Scattering elements are fabricated with different geometric dimensions and arrangements, to scatter or focus light at the same focal distance for each wavelength, or at different focal distances according to the desired application. Scattering elements can be circular or elliptical posts, allowing polarization dependent scattering. The elements can have different orientations to scatter light from multiple wavelengths at the desired focal length.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: April 23, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Ehsan Arbabi, Amir Arbabi, Andrei Faraon
  • Patent number: 10266847
    Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: April 23, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Pin Wang, Lili Yang, David Baltimore
  • Patent number: 10266844
    Abstract: According to some embodiments herein, expression systems and methods for activity-dependent transcription of nucleic acids are provided. In some embodiments, adeno-associated viral vector systems comprise an immediate early gene promoter operably linked to a transcriptional activator. The transcription activator can be fused to an N-terminal portion of an immediate early gene, for example fos.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: April 23, 2019
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Todd E. Anthony
  • Patent number: 10267808
    Abstract: Methods and systems are provided for creating molecular barcodes or indicia for cellular constituents within single cells and for resolving such barcodes or indicia with super resolution technologies such as super resolution microscopy. By this approach, numerous molecular species that can be measured simultaneously in single cells. It has been demonstrated that multiple mRNA transcripts can be labeled with a spatially ordered sequence of fluorophores, and that barcode can be resolved. The methods and systems can be used for genome-wide transcriptional profiling in individual cells by super-resolution barcoding and suggest a general strategy to bring large-scale-omics approach into single cells.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: April 23, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: Long Cai
  • Patent number: 10266876
    Abstract: Methods and systems are provided for creating molecular barcodes or indicia for cellular constituents within single cells and for resolving such barcodes or indicia with super-resolution technologies such as super-resolution microscopy. By this approach, numerous molecular species that can be measured simultaneously in single cells. It has been demonstrated that multiple mRNA transcripts can be labeled with a spatially ordered sequence of fluorophores, and that barcodes can be resolved. In addition, alternative splicing events can be characterized by identifying and quantifying mRNA isoforms in an individual cell.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 23, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Long Cai, Eric Lubeck
  • Publication number: 20190115979
    Abstract: A receiver, transmitter, and photon counting detector for use in an optical communication link are disclosed. Also disclosed are methods of communicating using the transmitter, the receiver, and the photon detector.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 18, 2019
    Applicant: California Institute of Technology
    Inventors: William H. Farr, Meera Srinivasan, Andre Wong