Patents Assigned to Cambridge Polymer Group, Inc.
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Publication number: 20140097559Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: ApplicationFiled: September 25, 2013Publication date: April 10, 2014Applicants: Cambridge Polymer Group, Inc., The General Hospital CorporationInventors: Orhun K. MURATOGLU, Edward T. Kopesky, Ebru Oral
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Patent number: 8637063Abstract: The invention provides methods of making hydrolyzed cross-linked polyvinyl alcohol (PVA) hydrogels by polymerizing vinyl acetate (VAc) monomers to polyvinyl acetate (PVAc) polymer network by chemical-crosslinking and hydrolysis. The invention also provides methods for including pendant chains in the hydrogel during the polymerization process. Materials produced and use of the cross-linked hydrolyzed PVA hydrogels also are disclosed herein.Type: GrantFiled: December 7, 2009Date of Patent: January 28, 2014Assignee: Cambridge Polymer Group, Inc.Inventors: Edward T. Kopesky, Jason Berlin, Martin F. Van Buren, Gavin J. C. Braithwaite
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Patent number: 8569395Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: GrantFiled: July 31, 2012Date of Patent: October 29, 2013Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Patent number: 8530057Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: May 12, 2009Date of Patent: September 10, 2013Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20130200555Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: March 14, 2013Publication date: August 8, 2013Applicants: Cambridge Polymer Group, Inc., The General Hospital CorporationInventors: The General Hospital Corporation, Cambridge Polymer Group, Inc.
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Publication number: 20130062817Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: ApplicationFiled: September 7, 2012Publication date: March 14, 2013Applicants: Cambridge Polymer Group, Inc., The General Hospital CorporationInventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
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Patent number: 8318065Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: GrantFiled: October 14, 2010Date of Patent: November 27, 2012Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20120292816Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: ApplicationFiled: July 31, 2012Publication date: November 22, 2012Applicants: Cambridge Polymer Group, Inc., The General Hospital CorporationInventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Patent number: 8293811Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: GrantFiled: January 25, 2008Date of Patent: October 23, 2012Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orthun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Publication number: 20120215321Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: April 23, 2012Publication date: August 23, 2012Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation dba Massachusetts General HospitalInventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 8076387Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: GrantFiled: June 25, 2010Date of Patent: December 13, 2011Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley
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Publication number: 20110256201Abstract: The invention provides methods of making hydrolyzed cross-linked polyvinyl alcohol (PVA) hydrogels by polymerizing vinyl acetate (VAc) monomers to polyvinyl acetate (PVAc) polymer network by chemical-crosslinking and hydrolysis. The invention also provides methods for including pendant chains in the hydrogel during the polymerization process. Materials produced and use of the cross-linked hydrolyzed PVA hydrogels also are disclosed herein.Type: ApplicationFiled: December 7, 2009Publication date: October 20, 2011Applicant: CAMBRIDGE POLYMER GROUP, INC.Inventors: Edward T. Kopesky, Jason A. Berlin, Martin F. Van Buren, Gavin J.C. Braithwaite
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Patent number: 8038927Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: January 20, 2010Date of Patent: October 18, 2011Assignees: The General Hosital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20110109017Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: January 20, 2010Publication date: May 12, 2011Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20110104003Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: January 10, 2011Publication date: May 5, 2011Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 7906064Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: November 29, 2006Date of Patent: March 15, 2011Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20110039969Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: ApplicationFiled: October 14, 2010Publication date: February 17, 2011Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20110004315Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: September 15, 2010Publication date: January 6, 2011Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
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Patent number: 7833452Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: GrantFiled: May 10, 2005Date of Patent: November 16, 2010Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20100262251Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: ApplicationFiled: June 25, 2010Publication date: October 14, 2010Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley