Patents Assigned to Cancer Hospital, Chinese Academy of Medical Sciences
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Publication number: 20240424320Abstract: A method and system for determining a spatiotemporal fractionation radiotherapy planning, belonging to the technical field of medical equipment which involves acquiring pathological images; identifying the acquired pathological images to determine the region of interest in the pathological images as the radiotherapy region; arranging the irradiation field direction according to the shape of the radiotherapy region, setting the optimization conditions of the radiotherapy planning according to clinical prescription requirements, and planning the radiotherapy path; evaluating the plan quality based on the planned optimization model for the planned radiotherapy path, and resetting the optimization conditions for unsuitable radiotherapy plans until the plan quality meets the requirements; outputting the radiotherapy path that meets the plan quality requirements as the final spatiotemporal fractionation radiotherapy plan.Type: ApplicationFiled: June 11, 2024Publication date: December 26, 2024Applicant: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES AND PEKING UNION MEDICAL COLLEGEInventors: Min Ma, Jianrong Dai
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Patent number: 12094612Abstract: A tumor diagnosis system and a construction method thereof, a terminal device and a storage medium are provided, wherein a radiomics signature is obtained by a radiomics signature-generation module in the tumor diagnosis system according to target radiomics information and clinical data information, based on a pre-trained radiomics signature model; a first classification comprehensive diagnosis result is obtained by a benign and malignant comprehensive classification module according to a ambient situation of a lesion outside an intestinal wall, the clinical data information and a first radiomics signature, based on a pre-trained first classification comprehensive diagnosis model; a second classification comprehensive diagnosis result is generated through a malignant focus sub-classification module based on a pre-trained second classification comprehensive diagnosis model, if the first classification comprehensive diagnosis result includes high-risk malignant information; and a final diagnosis result is obtaiType: GrantFiled: October 31, 2023Date of Patent: September 17, 2024Assignee: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Qing Zhao, Hongmei Zhang, Xinming Zhao
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Patent number: 12054710Abstract: A method of ctDNA library construction and sequencing data analysis for simultaneously detecting multiple common mutations in liver cancer. The library construction method and sequencing data analysis process have the following advantages: 1. Simultaneous detection of multiple mutation forms in liver cancer without capturing; 2. Suitable for efficient capture of ultra-small target regions; 3. The library may support 10-20 tests; 4. Ligate the DNA barcode to the starting ctDNA molecule during the library construction process, and cooperate with the biological information analysis process to achieve high specific detection of low-frequency mutations in ctDNA; 5. The library is usable for PCR hot spots detection and sequencing by a capture method at the same time, the added DNA barcode may effectively filter out false positive mutations and achieve high-specificity sequencing based on duplex.Type: GrantFiled: April 11, 2019Date of Patent: August 6, 2024Assignees: CANCER HOSPITAL CHINESE ACADEMY OF MEDICAL SCIENCES, GENETRON HEALTH (BEIJING) CO, LTD.Inventors: Yuchen Jiao, Chunfeng Qu, Pei Wang, Kun Chen, Yuting Wang, Qianqian Song, Sizhen Wang, Hai Yan
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Patent number: 12057234Abstract: A system for predicting therapy resistance and its molecular mechanisms in rectal cancer before treatment is provided. The system includes a feature extraction device, a collection device, a signature construction device and a prediction device. The system can predict responses to neoadjuvant therapy in patients before treatment, analyze patients who are resistant to rectal cancer therapy and their underlying molecular mechanism, thereby enabling personalized therapy for patients who are resistant to rectal cancer therapy. The system has important clinical significance in improving the overall survival of rectal cancer patients.Type: GrantFiled: October 31, 2023Date of Patent: August 6, 2024Assignee: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Qing Zhao, Xu Guan, Enrui Liu, Ran Wei, Xiaoxiao Song
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Patent number: 12027255Abstract: A system for predicting microsatellite instability and a construction method thereof, a terminal device and a medium are provided. Target image information, pathological specimen information and clinical data information of a user to be predicted are acquired by an acquisition module in the system for predicting microsatellite instability; a radiomics signature is generated according to the target image information, and a pathomics signature is generated according to the pathological specimen information, by a signature generation module, based on a pre-trained MSI-H/dMMR multi-omics signature model; and MSI-H/dMMR prediction results are generated according to the radiomics signature, the pathomics signature and the clinical data information, by a prediction generation module, based on a pre-trained MSI-H/dMMR prediction model.Type: GrantFiled: October 31, 2023Date of Patent: July 2, 2024Assignee: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Qing Zhao, Hongxia Zhong, Hongmei Zhang, Xinming Zhao
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Publication number: 20240062904Abstract: A tumor diagnosis system and a construction method thereof, a terminal device and a storage medium are provided, wherein a radiomics signature is obtained by a radiomics signature-generation module in the tumor diagnosis system according to target radiomics information and clinical data information, based on a pre-trained radiomics signature model; a first classification comprehensive diagnosis result is obtained by a benign and malignant comprehensive classification module according to a ambient situation of a lesion outside an intestinal wall, the clinical data information and a first radiomics signature, based on a pre-trained first classification comprehensive diagnosis model; a second classification comprehensive diagnosis result is generated through a malignant focus sub-classification module based on a pre-trained second classification comprehensive diagnosis model, if the first classification comprehensive diagnosis result includes high-risk malignant information; and a final diagnosis result is obtaiType: ApplicationFiled: October 31, 2023Publication date: February 22, 2024Applicant: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Qing ZHAO, Hongmei ZHANG, Xinming ZHAO
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Publication number: 20240062915Abstract: A system for predicting therapy resistance and its molecular mechanisms in rectal cancer before treatment is provided. The system includes a feature extraction device, a collection device, a signature construction device and a prediction device. The system can predict responses to neoadjuvant therapy in patients before treatment, analyze patients who are resistant to rectal cancer therapy and their underlying molecular mechanism, thereby enabling personalized therapy for patients who are resistant to rectal cancer therapy. The system has important clinical significance in improving the overall survival of rectal cancer patients.Type: ApplicationFiled: October 31, 2023Publication date: February 22, 2024Applicant: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Qing ZHAO, Xu GUAN, Enrui LIU, Ran WEI, Xiaoxiao SONG
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Publication number: 20240062881Abstract: A system for predicting microsatellite instability and a construction method thereof, a terminal device and a medium are provided. Target image information, pathological specimen information and clinical data information of a user to be predicted are acquired by an acquisition module in the system for predicting microsatellite instability; a radiomics signature is generated according to the target image information, and a pathomics signature is generated according to the pathological specimen information, by a signature generation module, based on a pre-trained MSI-H/dMMR multi-omics signature model; and MSI-H/dMMR prediction results are generated according to the radiomics signature, the pathomics signature and the clinical data information, by a prediction generation module, based on a pre-trained MSI-H/dMMR prediction model.Type: ApplicationFiled: October 31, 2023Publication date: February 22, 2024Applicant: CANCER HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Qing ZHAO, Hongxia ZHONG, Hongmei ZHANG, Xinming ZHAO
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Patent number: 11541250Abstract: A method for planning a scan path for intraoperative radiation therapy may comprise acquiring a plurality of images of a region of interest through an auxiliary scanning component, establishing a 3D model of the region of interest based on the plurality of images of the region of interest, determining a radiation therapy volume based on the 3D model of the region of interest, and planning a scan path for a radiation therapy component to scan the radiation therapy volume.Type: GrantFiled: May 14, 2018Date of Patent: January 3, 2023Assignee: Cancer Hospital, Chinese Academy of Medical SciencesInventors: Jianrong Dai, Pan Ma, Chuanmeng Niu, Minghui Li
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Patent number: 11110302Abstract: A multi-robotic arm apparatus for intraoperative radiotherapy is provided. The apparatus may comprise a chassis, a main robotic arm mounted on the chassis for moving a radiation head installed at an end thereof, a first robotic arm mounted on the chassis having a first robotic arm end gripper for gripping an imaging device or a treatment applicator; and a second robotic arm mounted on the chassis having a second robotic arm end gripper for gripping a simulation applicator.Type: GrantFiled: May 14, 2018Date of Patent: September 7, 2021Assignee: Cancer Hospital, Chinese Academy of Medical SciencesInventors: Jianrong Dai, Chuanmeng Niu, Pan Ma, Minghui Li
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Patent number: 10359426Abstract: The present invention relates to a method for diagnosing lung cancers such as non-small lung cancer in a subject by using isocitrate dehydrogenase 1 as a diagnostic biomarker. The present invention also relates to a method for predicting the prognosis of the lung cancers such as non-small lung cancer in a subject by using isocitrate dehydrogenase 1 as a prognostic biomarker. The present invention further relates to a method of suppressing proliferation of lung tumor cells in a subject, decreasing growth of lung tumor cells in a subject, or improving survival of a subject with lung cancer by using isocitrate dehydrogenase 1 as a therapeutic target.Type: GrantFiled: September 28, 2017Date of Patent: July 23, 2019Assignee: Cancer Hospital, Chinese Academy of Medical SciencesInventors: Jie He, Fengwei Tan, Zhaoli Chen, Nan Sun
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Patent number: 9797904Abstract: The present invention relates to a method for diagnosing the lung cancers such as non small lung cancer in a subject by using isocitrate dehydrogenase 1 as a diagnostic biomarker. The present invention also relates to a method for predicting the prognosis of the lung cancers such as non small lung cancer in a subject by using isocitrate dehydrogenase 1 as a prognostic biomarker. The present invention further relates to a method to suppress proliferation of lung tumor cells in a subject, decrease growth of lung tumor cells in a subject, or improve survival of a subject with lung cancer by using isocitrate dehydrogenase 1 as a therapeutic target.Type: GrantFiled: September 13, 2012Date of Patent: October 24, 2017Assignee: Cancer Hospital, Chinese Academy of Medical SciencesInventors: Jie He, Fengwei Tan, Zhaoli Chen, Nan Sun