Patents Assigned to Caridianbct, Inc.
  • Patent number: 8202240
    Abstract: Method and apparatus for separating plasma from blood in a membrane separator and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the membrane separator to receive the separated plasma.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: June 19, 2012
    Assignee: CaridianBCT, Inc.
    Inventors: Thomas J. Felt, Frank Corbin, III, Steven Gage Urdahl
  • Publication number: 20120145619
    Abstract: An integrated pre-connected apheresis disposable set for separating plasma from blood in a separation vessel and further separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.
    Type: Application
    Filed: February 21, 2012
    Publication date: June 14, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Steven Gage URDAHL, Thomas J. FELT, Frank CORBIN, III
  • Publication number: 20120086657
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Publication number: 20120089930
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. Medina
  • Publication number: 20120088224
    Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Thomas G. DILORENZO, Edward Allan STANTON, IV, Glen Delbert ANTWILER, Michael E. KINZIE, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd
  • Patent number: 8120760
    Abstract: Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 21, 2012
    Assignee: CaridianBCT, Inc.
    Inventors: Briden Ray Stanton, Geert Van Waeg
  • Patent number: 8114003
    Abstract: A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: February 14, 2012
    Assignee: CaridianBCT, Inc.
    Inventors: Todd Curtis Green, Bruce W. Gibbs
  • Publication number: 20120015794
    Abstract: A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.
    Type: Application
    Filed: July 5, 2011
    Publication date: January 19, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Brian M. HOLMES, Briden Ray STANTON, Geert VAN WAEG, Robert Langley, Mary Langley
  • Publication number: 20120015795
    Abstract: The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 19, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Dennis J. HLAVINKA, John R. MERKLING
  • Publication number: 20120010062
    Abstract: A method and apparatus for collecting a maximum amount of platelets for a selected blood separation procedure without collecting excess platelets above those required for a selected platelet product, whether that product was one unit of platelets, two units of platelets (a double platelet), or more. The method and apparatus will continue to adjust the platelet yield target for platelet collection throughout the procedure without operator intervention, unless the selected procedure cannot be completed successfully, and the operator is required to select another allowed procedure.
    Type: Application
    Filed: June 20, 2011
    Publication date: January 12, 2012
    Applicant: CARIDIANBCT, INC.
    Inventors: Christopher FLETCHER, John PITTINGER
  • Patent number: 8088090
    Abstract: This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes at least a two-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: January 3, 2012
    Assignee: CaridianBCT, Inc.
    Inventors: Thomas J. Felt, Marlene Adele Bainbridge
  • Publication number: 20110312481
    Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into components, comprising a valve design that facilitates loading and unloading of sets of blood bags. The valves comprise a jaw mounted on a shaft, the jaw being adapted to apply radio frequency energy to seal a tube, a stepper motor section, and at least two position sensors. The valve sections are mounted on an upper plate, and the stepper motor sections are mounted on a lower plate. A main radio frequency coil is selectively electrically coupled to each of the valves through a multiplexing switch.
    Type: Application
    Filed: May 18, 2011
    Publication date: December 22, 2011
    Applicant: CARIDIANBCT, INC.
    Inventors: Hong Duc NGUYEN, Bruce ELLINGBOE, Darryl Hudock
  • Publication number: 20110301012
    Abstract: Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Application
    Filed: May 6, 2011
    Publication date: December 8, 2011
    Applicant: CARIDIANBCT, INC.
    Inventors: Victor D. DOLECEK, Darryl HUDOCK
  • Patent number: 8070663
    Abstract: A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: December 6, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: William Sweat
  • Patent number: 8070665
    Abstract: A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: December 6, 2011
    Assignee: CaridianBCT, Inc
    Inventors: Victor D. Dolecek, Daniel A. Joseph, Darryl Hudock
  • Publication number: 20110294640
    Abstract: Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Application
    Filed: April 26, 2011
    Publication date: December 1, 2011
    Applicant: CARIDIANBCT, INC.
    Inventor: Victor D. DOLECEK
  • Publication number: 20110294641
    Abstract: A multi-unit blood processor uses a hydraulic bladder system to express blood components out of whole blood bags and into collection bags. A dummy whole blood bag, containing an inert fluid, may be placed in a processing location. The dummy bag has characteristics that allow the blood processor to recognize the presence of the dummy bag. An opaque feature may be detected by a photo sensor. A radio frequency sensor may be used to detect a passive radio frequency emitter on the dummy bag. The dummy bag may have a bar code label identifying it as a dummy bag. The blood processor will not attempt to process the dummy bag.
    Type: Application
    Filed: April 22, 2011
    Publication date: December 1, 2011
    Applicant: CARIDIANBCT, INC.
    Inventors: Victor D. DOLECEK, Darryl HUDOCK, Paul MESSENGER
  • Patent number: 8066888
    Abstract: A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: November 29, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: William Sweat, Jeremy Kolenbrander, John R. Lindner, Jennifer Hinz
  • Patent number: 8062202
    Abstract: A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: November 22, 2011
    Assignee: CaridianBCT, Inc.
    Inventor: William Sweat
  • Patent number: 8057376
    Abstract: A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: November 15, 2011
    Assignee: CaridianBCT, Inc.
    Inventors: James R. Ladtkow, Joseph A. Scibona, Jeremy Kolenbrander