Patents Assigned to Caris Life Sciences Switzerland Holdings GmbH
  • Patent number: 9958448
    Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: May 1, 2018
    Assignee: Caris Life Sciences Switzerland Holdings GMBH
    Inventors: David Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schafer, Nianqing Xiao
  • Patent number: 9939443
    Abstract: Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: April 10, 2018
    Assignee: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: David Spetzler, Valeriy Domenyuk, Tassilo Hornung, G√ľnter Mayer, Michael Famulok
  • Publication number: 20180030505
    Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.
    Type: Application
    Filed: August 4, 2017
    Publication date: February 1, 2018
    Applicant: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: Clive Gavin BROWN, Koen KAS, Sven Agnes Jan EYCKERMAN
  • Patent number: 9758811
    Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: September 12, 2017
    Assignee: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: Clive Gavin Brown, Koen Kas, Sven Agnes Jan Eyckerman
  • Patent number: 9469876
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: October 18, 2016
    Assignee: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: George Poste, Michael Klass, David Spetzler, Traci Pawlowski
  • Patent number: 9315804
    Abstract: The present invention is a method for the identification of one or more aptamers to at least one target molecule, the method comprising: selecting candidate aptamer sequences that bind to a target molecule, assigning to the bound sequences a measure (fitness function) of each sequence's aptameric potential, allowing evolution of some or all of the sequences to create a new mixture of candidate sequences, and repeating the method with the newly created candidate aptamer pool until the aggregate aptameric potential of the candidate pool reaches a plateau, wherein sequences present in the final pool are optimal aptamers to the target molecule.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: April 19, 2016
    Assignee: Caris Life Sciences Switzerland Holdings, GmbH
    Inventor: Clive Gavin Brown
  • Patent number: 9128101
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: September 8, 2015
    Assignee: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: David D. Halbert, George Poste, Michael Klass, David Spetzler, Traci Pawlowski, Daniel Holterman
  • Publication number: 20150087536
    Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 26, 2015
    Applicant: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: Clive Gavin BROWN, Koen KAS, Sven Agnes Jan EYCKERMAN