Patents Assigned to Cellomics, Inc.
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Patent number: 8103457Abstract: The present invention provides automated methods for cell body extension analysis, software for carrying out such methods, and detection devices comprising such software.Type: GrantFiled: March 15, 2010Date of Patent: January 24, 2012Assignee: Cellomics, Inc.Inventors: Everett Ramer, Oleg Lapets
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Patent number: 8090748Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.Type: GrantFiled: August 8, 2008Date of Patent: January 3, 2012Assignee: Cellomics, Inc.Inventors: Keith S. Boyce, Brian K. McKenna, Phillip W. Glick, R. Terry Dunlay
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Patent number: 8062856Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect neurite outgrowth.Type: GrantFiled: September 16, 2005Date of Patent: November 22, 2011Assignee: Cellomics, Inc.Inventors: Richik Ghosh, Robbin DeBiasio, Prem Janardhan
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Patent number: 8050868Abstract: The present invention provides automated methods and associated software for determining the organization of a component of interest in individual cells by determining the amount or distribution of the cellular component of interest as a function of position relative to a reference component in the individual cells.Type: GrantFiled: March 25, 2002Date of Patent: November 1, 2011Assignee: Cellomics, Inc.Inventors: Gustavo Rosania, Paul Sammak, Richard Rubin
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Patent number: 8024293Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.Type: GrantFiled: August 8, 2008Date of Patent: September 20, 2011Assignee: Cellomics, Inc.Inventors: Keith S. Boyce, Brian K. McKenna, Phillip W. Glick, R. Terry Dunlay
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Publication number: 20110096977Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.Type: ApplicationFiled: September 24, 2010Publication date: April 28, 2011Applicant: CELLOMICS, INC.Inventors: Michael A. Sipe, R. Terry Dunlay
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Publication number: 20110096976Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.Type: ApplicationFiled: September 24, 2010Publication date: April 28, 2011Applicant: CELLOMICS, INC.Inventors: Michael A. Sipe, R. Terry Dunlay
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Publication number: 20110043618Abstract: A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay.Type: ApplicationFiled: August 24, 2009Publication date: February 24, 2011Applicant: CELLOMICS, INC.Inventors: Richard C. Salisbury, Dirk John VandenBerg, III, Kim Anthony Ippolito
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Patent number: 7853409Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.Type: GrantFiled: June 4, 2007Date of Patent: December 14, 2010Assignee: Cellomics, Inc.Inventors: R. Terry Dunlay, D. Lansing Taylor
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Patent number: 7853411Abstract: The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of receptor internalization to a perinuclear location.Type: GrantFiled: October 15, 2003Date of Patent: December 14, 2010Assignee: Cellomics, Inc.Inventors: Richard Rubin, Kenneth Giuliano, Albert Gough, R. Terry Dunlay, Bruce Ray Conway
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Patent number: 7818130Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.Type: GrantFiled: December 9, 2005Date of Patent: October 19, 2010Assignee: Cellomics, Inc.Inventors: Michael A. Sipe, R. Terry Dunlay
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Publication number: 20100166287Abstract: The present invention provides automated methods for cell body extension analysis, software for carrying out such methods, and detection devices comprising such software.Type: ApplicationFiled: March 15, 2010Publication date: July 1, 2010Applicant: CELLOMICS, INC.Inventors: Everett Ramer, Oleg P. Lapets
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Patent number: 7706591Abstract: The present invention provides automated methods for cell body extension analysis, software for carrying out such methods, and detection devices comprising such software.Type: GrantFiled: July 13, 2006Date of Patent: April 27, 2010Assignee: Cellomics, Inc.Inventors: Everett Ramer, Oleg P. Lapets
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Patent number: 7565247Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.Type: GrantFiled: November 22, 2000Date of Patent: July 21, 2009Assignee: Cellomics, Inc.Inventors: R. Terry Dunlay, D. Lansing Taylor
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Patent number: 7482167Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.Type: GrantFiled: March 11, 2005Date of Patent: January 27, 2009Assignee: Cellomics, Inc.Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
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Patent number: 7476510Abstract: Methods and cassettes for cell-based toxin detection and organ localization are disclosed. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.Type: GrantFiled: January 5, 2007Date of Patent: January 13, 2009Assignee: Cellomics, Inc.Inventors: Ravi Kapur, Kenneth Giuliano
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Patent number: 7467153Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.Type: GrantFiled: August 27, 2003Date of Patent: December 16, 2008Assignee: Cellomics, Inc.Inventors: Keith Boyce, Brian McKenna, Phillip Glick, Terry Dunlay
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Publication number: 20080306989Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.Type: ApplicationFiled: August 8, 2008Publication date: December 11, 2008Applicant: Cellomics, Inc.Inventors: Keith S. Boyce, Brian K. McKenna, Phillip W. Glick, R. Terry Dunlay
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Publication number: 20080301202Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.Type: ApplicationFiled: August 8, 2008Publication date: December 4, 2008Applicant: Cellomics, Inc.Inventors: Keith S. Boyce, Brian K. McKenna, Phillip W. Glick, R. Terry Dunlay
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Patent number: 7410769Abstract: The present invention provides a protease biosensor that can be used to detect the presence of the lethal factor protease from Bacillus anthracis, as well as methods for using the protease biosensor.Type: GrantFiled: February 9, 2001Date of Patent: August 12, 2008Assignee: Cellomics Inc.Inventor: Sarah Burroughs-Tencza