Abstract: A method for diagnosing or prognosing, multiple sclerosis including the steps of (a) measuring the amount of at least one first protein as set forth in SEQ ID NO: 1, the at least first protein belonging to the group of proteins: a first protein, a second protein, a third protein, a fourth protein and a fifth protein, as set forth in SEQ ID NO 1 to 5, (b) comparing the amount of the at least first protein with the amount of the same protein in a control sample, and (c) determining the status of the biological sample.
Type:
Application
Filed:
May 22, 2019
Publication date:
November 25, 2021
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM), UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE NÎMES
Inventors:
Eric THOUVENOT, Philippe MARIN, Serge URBACH, Geoffrey HINSINGER
Abstract: The present invention relates to the field of human fertility treatment. The present invention more specifically relates to the identification of soluble CD146 (sCD146) as a biomarker which, when measured in an embryo culture medium, can be used to determine whether the embryo can be selected for implantation in the uterus of a mammal or not. The present invention thus provides a new tool and related kits to (pre)select embryo eligible for implantation. The invention also relates to methods for promoting pregnancy in a human who undergoes embryo transfer.
Type:
Grant
Filed:
April 21, 2016
Date of Patent:
October 20, 2020
Assignees:
CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX-MARSEILLE, ASSISTANCE PUBLIQUE — HÔPITAUX DE MARSEILLE
Abstract: The present invention relates to a hydrophobic polymer used in particular to produce and/or coat medical devices, in particular implantable medical devices, that are visible in magnetic resonance imaging, characterized in that it comprises at least one monomer unit on which is grafted a chelating ligand of a paramagnetic ion complexed with such a paramagnetic ion, said monomer unit having at least one carbonyl group, said monomer unit comprising, prior to grafting, at least one hydrogen atom in the ? position of said at least one carbonyl group, and said grafting of the chelating ligand taking place in the area of said at least one hydrogen atom in the ? position of said at least one carbonyl group.
Type:
Grant
Filed:
July 7, 2010
Date of Patent:
June 7, 2016
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER 2, UNIVERSITE DE MONTPELLIER 1, CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES
Inventors:
Sebastien Blanquer, Jean Coudane, Renaud De Tayrac, Xavier Garric, Vincent Letouzey, Olivier Guillaume
Abstract: The present invention relates to a hydrophobic polymer used in particular to produce and/or coat medical devices, in particular implantable medical devices, that are visible in magnetic resonance imaging, characterized in that it comprises at least one monomer unit on which is grafted a chelating ligand of a paramagnetic ion complexed with such a paramagnetic ion, said monomer unit having at least one carbonyl group, said monomer unit comprising, prior to grafting, at least one hydrogen atom in the a position of said at least one carbonyl group, and said grafting of the chelating ligand taking place in the area of said at least one hydrogen atom in the a position of said at least one carbonyl group.
Type:
Application
Filed:
July 7, 2010
Publication date:
July 12, 2012
Applicants:
Centre Hospitalier Universitaire de Nimes, Universite de Montpellier
Inventors:
Sebastien Blanquer, Jean Coudane, Renaud De Tayrac, Xavier Garric, Vincent Letouzey, Olivier Guillaume