Patents Assigned to Centre Hospitalier Universitaire Pontchaillou
  • Proficiency assessment system and method for deep brain stimulation (DBS)
    Patent number: 11756689
    Abstract: A method for simulating a deep-brain stimulation in a computer-assisted platform that includes providing to a neurosurgeon, through a man-machine interface, visual information of a pre-operative situation, including a representation of a brain. The method also includes monitoring inputs of said neurosurgeon on the man-machine interface, until a trajectory is determined between an entry point and a target for the placement of an electrode. The method further includes comparing said trajectory to a set of previously-established trajectories for the pre-operative situation, so as to determine an overall measurement representative of a quality of the trajectory compared to the previously-established trajectories.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: September 12, 2023
    Assignees: UNIVERSITÉ DE RENNES 1, INSERM—INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE HOSPITALIER UNIVERSITAIRE PONTCHAILLOU, QUEEN'S UNIVERSITY
    Inventors: Gabor Fichtinger, Matthew Holden, Pierre Jannin, Claire Haegelen, Yulong Zhao
  • TYRP1, a natural miRNA sponge, and its use in managing human melanoma aggressiveness
    Patent number: 10287633
    Abstract: The present invention relates to methods and reagents for the treatment of melanoma and/or of metastatic melanoma that directly or indirectly target TYRP1 RNA transcript. The invention also relates to methods for predicting if a melanoma patient will be therapeutically responsive to such methods of treatment and reagents, and to methods for assessing the effectiveness of such methods of treatment and reagents. The invention further relates to a combination of biological markers that allows the prediction of melanoma patients' survival irrespective of the treatment administered.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 14, 2019
    Assignees: UNIVERSITE DE RENNES 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIRE PONTCHAILLOU
    Inventors: David Gilot, Marie-Dominique Galibert, Ghanem Ghanem, Fabrice Journe
  • Lichesterinic acid and the derivatives of same as pigmentation inhibitors
    Patent number: 9265706
    Abstract: The invention relates to the cosmetic use of a compound chosen from the compounds of formula (A) and the salts of same as an agent for depigmenting the skin and/or keratinous appendages.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: February 23, 2016
    Assignees: Centre National de la Recherche Scientifique—CNRS, Universite de Rennes 1, Centre Hospitalier Universitaire Pontchaillou
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le Devehat, Marylene Chollet-Krugler, Sophie Tomasi, Nicolas Mouchet, Beatrice Legouin-Gardadennec
  • Paraconic acids as pigmentation activators
    Patent number: 8816101
    Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: August 26, 2014
    Assignees: Centre National de la Recherche Scientifique—CNRS, Universite de Rennes 1, Centre Hospitalier Universitaire Pontchaillou
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi
  • BIOMARKERS AND METHODS FOR THE PROGNOSIS OF GLIOBLASTOMA
    Publication number: 20140011702
    Abstract: The present invention relates to gene promoters whose methylation status correlates with the clinical survival outcome of glioblastoma patients treated according to the Stupp protocol. More specifically, the invention provides methods and kits for the prognosis of survival outcome and/or treatment response in glioblastoma patients.
    Type: Application
    Filed: December 13, 2011
    Publication date: January 9, 2014
    Applicant: CENTRE HOSPITALIER UNIVERSITAIRE PONTCHAILLOU
    Inventors: Jean Mosser, Amandine Etcheverry, Marc Aubry, Jean-Yves Delattre
  • PARACONIC ACIDS AS PIGMENTATION ACTIVATORS
    Publication number: 20120329868
    Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).
    Type: Application
    Filed: March 4, 2011
    Publication date: December 27, 2012
    Applicants: Centre National de la Recherche Scientifique - CNRS, Centre Hospitalier Universitaire Pontchaillou, Universite de Rennes 1
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi