Patents Assigned to Centre National de la Recherche Scientifique
  • Patent number: 11866373
    Abstract: A method for coating fibers, includes desizing sized short fibers having an average length less than or equal to 5 mm, the short fibers being made of ceramic material or carbon, sieving the desized short fibers in order to separate them from any agglomerates of sized short fibers still present, introducing the desized and sieved short fibers into a reactor, and coating the short fibers in the reactor by chemical vapor deposition in a fluidized bed.
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: January 9, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SAFRAN CERAMICS, UNIVERSITE DE BORDEAUX
    Inventors: Arnaud Delehouze, Eric Bouillon, Amine El Mansouri, Nathalie Dominique Bertrand, Alain Jean-Michel Guette
  • Patent number: 11865185
    Abstract: The invention is directed to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. The present invention further relates to a method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L and to a Recombinant Adeno-Associated Virus (rAAV) vector particle obtained by said method as well as a pharmaceutical composition comprising it and their corresponding medical use.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: January 9, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), NANTES UNIVERSITE, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
    Inventors: Mathieu Mevel, David Deniaud, Eduard Ayuso
  • Publication number: 20240002776
    Abstract: The present invention relates to a device (2) for providing a liquid medium with a controlled flow rate and with a controlled concentration of a dissolved gas, the device (2) comprising: —a liquid reservoir (4) provided with: —at least one gas inlet (7); —at least one gas outlet (8); and—at least one liquid outlet (9); —an admission line (5) configured to provide a gaseous medium into the liquid reservoir (4), the admission line (5) being connected to the at least one gas inlet (7) and comprising at least one control valve (12); and an emission line (6) configured to withdraw the gaseous medium from the liquid reservoir (4), the emission line (6) being connected to the at least one gas outlet (8) and comprising at least one control valve (15). The present invention further relates to an assembly comprising said device, and to a method for providing a liquid medium with a controlled flow rate and with a controlled concentration in a dissolved gas.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 4, 2024
    Applicants: Sorbonne Universite, Centre National De La Recherche Scientifique, Institut Curie, Fluigent
    Inventors: William Cesar, Charlotte Bouquerel, Marine Verhulsel, Jean-Louis Viovy, Stéphanie Descroix
  • Publication number: 20240003870
    Abstract: A method of selecting T cells with improved anti-cancer activity, the method including: a) quantifying glucose transporter 1 (GLUT1) expression level at the cell surface of a population of T cells by using a GLUT1 ligand, b) selecting T cells having a low GLUT1 expression level, wherein the T cells having a low GLUT1 expression level have improved anti-cancer activity. Also, a population of T cells with improved anti-cancer activity for use in the treatment of cancer, to the use of a GLUT1 ligand for selecting T cells with improved anti-cancer activity, and to the use of GLUT1 as a biomarker of the anti-cancer therapeutic efficacy of T cells.
    Type: Application
    Filed: November 5, 2021
    Publication date: January 4, 2024
    Applicants: METAFORA BIOSYSTEMS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, THE UNITED STATES OF AMERICA ,ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE
    Inventors: Naomi TAYLOR, Marie Charlotte Chantal POUZOLLES, Valérie DARDALHON, Vincent PETIT
  • Publication number: 20240002832
    Abstract: A method for isolating molecules and/or molecular complexes having a radius of gyration smaller or equal to 2 ?m from a complex fluid, including the steps of: a) contacting a complex fluid with a structured capture array having topographical features, wherein the structured capture array is placed in an environment with surrounding humid air humidity of at least 40% based on the maximal moisture content, b) covering the deposited complex fluid with a covering element, wherein the surface tension of the complex fluid between the covering element and the structured capture array defines at least a front and a rear meniscus; and c) dragging either the covering element or the structured capture array in one direction at a speed of at most 2 mm·s?1 for displacing the complex fluid, resulting in that the molecules and/or the molecular complexes are trapped inside the cavities.
    Type: Application
    Filed: December 7, 2021
    Publication date: January 4, 2024
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
    Inventors: Aline CERF, Christophe VIEU, Hélène CAYRON, Mouhanad BABI, Denis ESTRADE, Alexiane LARROCHE
  • Publication number: 20240002522
    Abstract: Novel anti-human CD25 antibodies or antigen-binding fragments thereof and their use for treating cancer and infectious diseases. Also, a nucleic acid encoding an anti-human CD25 antibody or antigen-binding fragment thereof, and a fusion protein including an isolated anti-human CD25 antibody or antigen-binding fragment thereof. Further, a pharmaceutical composition including an isolated anti-human CD25 antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: November 19, 2021
    Publication date: January 4, 2024
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INSTITUT JEAN PAOLI & IRENE CALMETTES, ALDERANN BIOTECHNOLOGY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE, UNIVERSITE PARIS CITE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Daniel OLIVE, Armand BENSUSSAN, Jerome GIUSTINIANI, Anne MARIE-CARDINE, Amaud FOUSSAT, Jemila HOUACINE
  • Patent number: 11859150
    Abstract: Compositions resulting from the mixing of at least one copolymer A1, resulting from the copolymerization of at least one monomer functionalized by diol functions with at least one styrenic monomer, and at least one compound A2 comprising at least two boronic ester functions. They have very varied rheological properties depending on the proportion of compounds A1 and A2 used. Composition resulting from the mixing of at least one lubricating oil with such a composition of associative and exchangeable polymers and use of this composition for lubricating a mechanical part.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: January 2, 2024
    Assignees: TOTAL MARKETING SERVICES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thibault Derouineau, Fanny Briand, Gregory Descroix, Renaud Nicolay
  • Patent number: 11857616
    Abstract: The present invention relates to recombinant measles virus expressing Zika virus proteins and their applications, in particular in inducing preventive protection against Zika virus. The present invention is directed to recombinant measles virus (MV) expressing at least (i) the precursor of membrane (prM) protein of a Zika virus (ZIKV), and the envelope (E) protein of a ZIKV or a truncated version thereof, or (ii) the E protein of a ZIKV or a truncated version thereof, and concerns recombinant infectious particles of said MV-ZIKV able to replicate in a host after an administration, and also Virus Like Particles (VLPs) that contain these ZIKV proteins at their surface. The present invention provides means, in particular nucleic acids, vectors, cells and rescue systems to produce these recombinant infectious particles and VLPs.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: January 2, 2024
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frederic Tangy, Etienne Simon-Loriere
  • Patent number: 11858859
    Abstract: A method for treating a carbon or ceramic yarn includes forming a coating on the yarn in a reaction zone of a reactor by heating a segment of the yarn in the presence of a gas phase in a microwave field, wherein the gas phase includes a mixture of a diluent gas and a coating precursor in the vapor state, and wherein the gas phase is formed at least by introducing the diluent gas into the reactor and mixing the introduced diluent gas with the coating precursor in the reactor before the reaction zone.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: January 2, 2024
    Assignees: SAFRAN CERAMICS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX
    Inventors: Arnaud Delehouze, Pierre Fenetaud, Sylvain Lucien Jacques
  • Publication number: 20230421094
    Abstract: A method for optimizing an existing generator system based on photovoltaic cells and provided with an existing photovoltaic panel or a group of existing photovoltaic panels, each panel having a first plurality of cells of a first type interconnected in series or in series/in parallel. The method includes: determining an operating voltage of the panel(s); producing additional panel module(s) having a second plurality of thin-film cells of a second type and having a different band gap width than the cells of the panel(s), the additional module(s) being configured to supply an operating voltage equal, within ±10%, to the voltage of the panel(s); positioning the additional module to overlap on or under the panel or one of the panel(s), the module being connected in parallel to the panel(s), or positioning several additional modules to overlap on or under several panels, the several modules being connected in parallel to panels.
    Type: Application
    Filed: November 19, 2021
    Publication date: December 28, 2023
    Applicants: ELECTRICITE DE FRANCE, INSTITUT PHOTOVOLTAIQUE D'ILE DE FRANCE (IPVF), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, TOTALENERGIES ONETECH, ECOLE POLYTECHNIQUE
    Inventors: Sébastien JUTTEAU, Pierre-Philippe GRAND, Cédric GUERARD, Etienne DRAHI
  • Patent number: 11852704
    Abstract: The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: December 26, 2023
    Assignees: Siemens Healthcare GmbH, Centre National de la Recherche Scientifique (CNRS), Institut National de La Sante et de la Recherche Medicale (INSERM), King's College London, Department of Health and Human Services, UNIV PARIS XIII PARIS-NORD VILLETANEUSE, Universite de Paris
    Inventors: Giacomo Annio, Verena Muller-Reinwald, Ralph Sinkus, Omar Darwish, Wilfried Schnell, Tamara Elisabeth Falkner, Ahmed M. Gharib
  • Patent number: 11852580
    Abstract: A sensor for photoacoustic spectroscopy including a support and a mechanical resonator fastened to the support, including at least one sensor element designed to be vibrated by an acoustic wave, and at least one first capacitive electrode mechanically coupled to the sensor element so as to be moved by the sensor element when it is vibrated; and at least one second capacitive electrode forming with the at least one first electrode, a capacitive sensor; the support facing the sensor element, an apertured part formed by one or more through-openings. Also provided is a detection and/or measurement device and method, for photoacoustic spectroscopy, using such a sensor.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: December 26, 2023
    Assignees: UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Aurore Vicet, Kaim Chamassi, Michaël Bahriz
  • Patent number: 11854801
    Abstract: A method for depositing an object, including: —approaching, in an enclosure, a holder in the direction of a carrier substrate, then—transferring, in the enclosure, the object from the holder to an area for depositing the carrier substrate. The transfer step is preferably carried out when the inside of the enclosure is in a vacuum at a pressure below 10?6 bar.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: December 26, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE, SORBONNE UNIVERSITE, UNIVERSITE DE PARIS
    Inventors: Matthieu Delbecq, Tino Cubaynes, José Palomo, Matthieu Dartiailh, Takis Kontos, Matthieu Desjardins
  • Patent number: 11856093
    Abstract: A method for performing spacetime-constrained oblivious transfer between various laboratories of a first party A and various laboratories of a second party B. The method includes providing the spacetime-constrained oblivious transfer to satisfy various conditions. The method further includes encoding, by the laboratories of the first party A, various messages in a quantum state selected from various non-orthogonal quantum states. The method further includes transmitting, by the laboratories of the first party A, the quantum state to a first laboratory of the second party B. The method further includes applying, by the first laboratory of the second party B, a quantum measurement on the quantum state to obtain a classical measurement outcome. The method further includes transmitting, by the first laboratory of the second party B, the classical measurement outcome to the laboratories of the second party B.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: December 26, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PARIS CITÉ
    Inventors: Damián Pitalúa García, Iordanis Kerenedis
  • Patent number: 11851696
    Abstract: The present invention relates to a recombinant microorganism which exhibits i) a conversion activity from D-ribulose-5-phosphate into D-arabinose-5-phosphate, increased in comparison with the same, non-modified microorganism; ii) a cleavage catalysis activity from D-arabinose-5-phosphate into D-glyceraldehyde-3-phosphate and glycolaldehyde, increased in comparison with the same, non-modified microorganism; iii) an oxidation activity from glycolaldehyde into glycolate, increased in comparison with the same, non-modified microorganism; and iv) an oxidation activity from glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate, decreased in comparison with the same, non-modified microorganism. The present invention also relates to a process for preparing glycolic acid from pentoses and/or hexoses, using such a recombinant microorganism.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: December 26, 2023
    Assignees: Institut National Des Sciences Appliquées De Toulouse, Centre National De La Recherche Scientifique, Institut National Recherche Pour L'Agriculture, L'Alimentation Et L'Environement
    Inventors: Cléa Lachaux, Thomas Walther, Jean-Marie Francois
  • Publication number: 20230411035
    Abstract: The present disclosure relates to a method for arranging atoms in a target array of optical traps with predefined positions comprising: generating a given number of target traps at said predefined positions; generating reservoir traps, said reservoir traps and said target traps forming a traps array; defining allowed paths between traps of the traps array; loading atoms in the traps array to generate an initial loaded traps array; determining the positions of the atoms in the initial loaded traps array; calculating a sequence of moves using a rearrangement algorithm based on said initial loaded traps array and said allowed paths; and applying the sequence of moves to rearrange the atoms in the traps array and form a final loaded traps array.
    Type: Application
    Filed: November 8, 2021
    Publication date: December 21, 2023
    Applicants: Institut d'Optique Théorique et Appliquée, Centre National de la Recherche Scientifique
    Inventors: Kai-Niklas Schymik, Vincent Lienhard, Daniel Barredo, Antoine Browaeys, Thierry Lahaye
  • Patent number: 11845720
    Abstract: A heptane composition obtained from a plant source is described, wherein the plant source comprises Commiphora wildii and wherein the heptane composition is obtained by a process of extraction comprising hydrodistilling or steam distilling a resin of Commiphora wildii to obtain an essential oil. A method of using the heptane composition as a solvent for extracting one or more natural products is also described.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: December 19, 2023
    Assignees: UNIVERSITÉ CÔTE D'AZUR, Centre National de la Recherche Scientifique
    Inventors: Anne-Sophie Bouville, Cyrielle Dieffoldo, Xavier Fernandez, Stéphane Piquart
  • Patent number: 11845830
    Abstract: The present invention relates to a method for producing a composition comprising at least one polyurethane with NCO end groups, and at least one catalyst B selected from among tertiary amines, said method comprising the following steps: a) production of a polyurethane with NCO end groups, comprising a step of polyaddition of a polyol composition and a polyisocyanate composition, in the presence of at least one catalyst A selected from the group consisting of—organo-metallic catalysts excluding tin-based catalysts, —tertiary amines, and—mixtures of same; and b) the addition of at least one catalyst B, selected from among tertiary amines, to the polyurethane with NCO end groups obtained in step a).
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 19, 2023
    Assignees: BOSTIK SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON FORMATION CONTINUE ET RECHERCHE—CPE LYON FCR
    Inventors: Federico Sanz, Guillaume Michaud, Frédéric Simon, Jean Raynaud, Vincent Monteil, Lionel Bosco
  • Patent number: 11846589
    Abstract: A method for manufacturing an ion sensor, especially a pH measurement sensor, based on optical fibre, including the following steps: cleaving the optical fibre, with free hydroxyl groups appearing on the cleavage surface, grafting a layer of trifunctional silane directly on free hydroxyl groups having appeared accordingly on the cleavage surface of the optical fibre, without a prior external activation step, grafting a layer of difunctional silane on the cleavage surface of the optical fibre, and grafting a fluorescent dye.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: December 19, 2023
    Assignees: UNIVERSITE DE FRANCHE-COMTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Bernard Gauthier-Manuel, Rutjaphan Kateklum
  • Patent number: 11845944
    Abstract: The disclosure relates to a promoter induced by fungal rust. More specifically, the promoter is induced by the pathogen Phakopsora pachyrhizi, i.e. the Asian Soybean Rust. The disclosure further provides for recombinant genes comprising the promoter and methods of producing a transgenic plant that involves introducing or providing the recombinant gene to plant cells to create transgenic plant cells, and regenerating transgenic plants from the transgenic cells.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: December 19, 2023
    Assignees: Centre National De La Recherche Scientifique, Institut National des Sciences Appliquees de Lyon, Universite Claude Bernard Lyon 1, BASF Agricultural Solutions Seed US LLC
    Inventors: Lisa Cabre, Sophie Ducerf, Stephane Peyrard, Catherine Sirven, Bernard Pelissier