Patents Assigned to Centre National de la Recherche Scientifque
  • Patent number: 10241169
    Abstract: Method for analyzing, using nuclear magnetic resonance, at least one sample including at least one species to be characterized and a reference species having a content, in the sample, that is more than twice greater than the content of the species to be characterized, the method includes: applying at least one constant field B0 to the at least one sample; acquiring, using one or more antenna(s), one or more complex free induction decay (FID) signal(s) S(t), with each complex FID signal S(t) including a real part and an imaginary part; with the acquisition step being carried out such that, in each complex FID signal S(t), the amplitude of the signal of the reference species is at least twice greater than the amplitude of the signal of the at least one species to be characterized; and for each complex FID signal S(t), calculating the module of each complex FID signal S(t).
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: March 26, 2019
    Inventor: Yann Le Fur
  • Patent number: 10215740
    Abstract: The present invention relates to a method for manufacturing a chromatography column, in particular for a gas phase chromatography, comprising a stationary phase made from a sol. This method comprises the following steps: (a) introducing this sol at the first end of the column, (b) moving said sol towards the second end of the column, so that a sol layer is formed on the internal wall of the column, this layer being able to form a gel on said internal wall, and (c) drying of the gel. The present invention also relates to a capillary column as well as to a microcolumn which may be manufactured according to this method.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: February 26, 2019
    Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE, UNIVERSITE Claude Bernard LYON 1, CPE Lyon FCR
    Inventors: David Lefebvre, Bernadette Charleux, Florence Ricoul, Chloe Thieuleux
  • Patent number: 9471061
    Abstract: The invention relates to a method for generating control commands for coordinating displacement members of a moving platform, so as to make said moving platform progress between an initial speed and a final speed according to at least two locomotive situations.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: October 18, 2016
    Assignees: Inria Institut National de Recehrche en Informatique et en Automatique, Université Versailles Saint-Quentin-en-Yvelines, Museum National D'Histoire Naturelle, Centre National de la Recherche Scientifque (C.N.R.S.)
    Inventors: Anick Abourachid, Ludovic Maes, Lionel Reveret, Vincent Hugel
  • Patent number: 9446360
    Abstract: A method and chip for fusing droplets in a chip comprising (i) providing a first set of droplets which are partially or not stabilized by surfactant, (ii) providing a second set of droplets which are stabilized by surfactant, (iii) contacting each droplet of the first set with single or multiple droplets of the second set in a pairing module and (iv) fusing droplets of the first set with droplets of the second set through a droplet fusion module in which the droplets experience at least one acceleration and/or deceleration and/or reorientation and/or rearrangement in space and time.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: September 20, 2016
    Inventor: Linas Mazutis
  • Patent number: 9216912
    Abstract: The invention relates to a method for preparing an alkali metal and transition metal fluorosulfate that is useful as an electrode material in an electrochemical battery that operates by alkali ion exchange. The method includes a first step that involves: preparing a mixture of precursors of elements making up fluorosulfate, placing said mixture in contact with a solid polymer at ambient temperature, subjecting the reaction medium to a heat treatment that aims to melt the polymer, and subsequently reacting the precursors with one another. Said polymer is one that is solid at ambient temperature, has a melting point lower than the reaction temperature of the precursors, is stable at least up to the reaction temperature of the precursors, and is soluble in a nonpolar aprotic organic solvent.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: December 22, 2015
    Assignee: Centre National de la Recherche Scientifque
    Inventors: Jean-Marie Tarascon, Mohamed Ati, Michel Armand, Nadir Recham
  • Publication number: 20150295236
    Abstract: The present invention relates to a negative electrode material for a sodium ion battery, and to a method for producing it. The active material of the electrode material is composed of an oxide with a structure corresponding to the layered structure of the compound Na2Ti3O7, said oxide conforming to the formula NaxTi(IV),Ti(III)bMcO7 (A), in which x denotes the number of Na+ ions inserted between the layers, per Ti3O7 structural unit, with 0<x?5; Ti(IV) and Ti(III) represent titanium in the oxidation states IV and III, respectively; M represents one or more elements selected from 3d transition metals and 4d transition metals; the values of x, a, b and c are such that the compound is electronically neutral in view of the oxidation state of the element or elements represented by M; and the ratio (a+b)/c is greater than 0.5. The electrode material is obtained by electrochemical reduction of an oxide Nax?Ti(IV)a?McO7(B).
    Type: Application
    Filed: July 2, 2012
    Publication date: October 15, 2015
    Applicants: Universite De Picardie Jules Verne, Centre National De La Recherche Scientifque, Agencia Estalal Consejo Superior De Investigaciones Cientifcas
    Inventors: Premkumar Senguttuvan, Rosa Maria Palacin, Jean-Marie Tarascon
  • Publication number: 20150168507
    Abstract: A micromagnetometry system for detecting the presence of very small quantities of magnetic particles comprises a first magnetic hybrid AMR/PHR multi-ring sensor using a Wheastone bridge electrical configuration, a first current source, a first voltage measurement device, a set of at least one magnetic particles deposited on the first magnetic sensor and a processing unit for detecting from a set of different measured differential voltages a magnetic flux shift representative of the presence of a least one deposited magnetic particle. The micromagnetometry system comprises means for creating a magnetic excitation field HAC to make produce by each motionless magnetic particle a stray magnetic field oscillating along the time at a constant frequency ? ranging from 10 Hz to 3 KHz.
    Type: Application
    Filed: July 12, 2013
    Publication date: June 18, 2015
    Inventors: Férial Terki, Azzedine Bousseksou, Quang Hung Tran, Souleyman Kamara, CheolGi Kim, Kun Woo Kim, Philippe Gandit
  • Publication number: 20150150929
    Abstract: The present invention concerns various cosmetic uses of compositions comprising an essential oil or one of its constituents, preferably a major constituent, in the targeted treatment and prevention of benign keratoses, and more particularly keratoses induced by solar radiation on the skin of a subject. More particularly, the present invention concerns compositions based on the essential oil of oregano or of rosewood, or on linalool, thymol or carvacrol. The present invention also concerns therapeutic applications of a composition as described in the prevention or targeted treatment of actinic keratoses, essentially for prophylactic purposes.
    Type: Application
    Filed: February 28, 2011
    Publication date: June 4, 2015
    Applicants: L O'real, Centre National De La Recherche Scientifque, Institut Curie
    Inventors: Laurent Marrot, Jérémie Soeur
  • Publication number: 20140249122
    Abstract: The present invention relates to novel aminosteroid derivatives substituted in position 3 andor 6, and to the use thereof in the context of the treatment of type 2 diabetes and of insulin resistance.
    Type: Application
    Filed: October 16, 2012
    Publication date: September 4, 2014
    Inventors: Roland Marinus Theodorus Govers, Jean-Michel Brunel
  • Patent number: 8742734
    Abstract: The invention relates to an active filter device for a power supply comprising a source having a source of current iS and a voltage VE, a power converter presenting an input inductor L, a power switch T controlled by a chopper signal and delivering an output voltage VS, and a load, the device being characterized in that it includes an active filter converter (10) for generating at its output a compensation current minus harmonics of the source current due to the chopping, in response to an input signal representative of the chopping of the power converter.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: June 3, 2014
    Assignees: Centre National de la Recherche Scientifque, Institut National Polytechnique de Lorraine, Universite Henri Poincare
    Inventors: Jean-Philippe Martin, Serge Lionel Pierfederici, Bernard Davat, Farid Meibody-Tabar
  • Publication number: 20130345441
    Abstract: Disclosed is a method for preparing, by transcarbonation, a compound of formula (I), including reacting a polyol of formula (II) with an alkyl carbonate or an alkylene carbonate in the presence of a catalytic system consisting of a catalytic entity selected from among the rare earth oxides or the mixtures thereof, and optionally an inert substrate.
    Type: Application
    Filed: January 11, 2012
    Publication date: December 26, 2013
    Inventors: Gerard Mignani, Marc Lemaire, Eric Da Silva, Wissam Dayoub, Yann Raoul
  • Publication number: 20130017547
    Abstract: The present invention relates to isolated organ-specific feline endothelial cells. Specifically, the present invention relates to established organ-specific feline endothelial cells. The present invention also relates to organ-specific feline endothelial cells derived from micro- and macro-vascularisation. The present invention also relates to methods for screening molecules, for studying pathologies and for producing pathogens using same.
    Type: Application
    Filed: January 11, 2011
    Publication date: January 17, 2013
    Inventors: Claudine Kieda, Maria Paprocka, Michele Mitterand, Nathalie Lamerant-Fayel, Henri-Jean Boulouis, Nadia Haddad, Martine Monteil
  • Publication number: 20110273711
    Abstract: The invention relates to a method and to a device for determining a piece of polarisation information on a measurement point of a target sample, the device comprising: -a light source capable of emitting a rectilinearly polarised light beam in a predefined direction, the light beam being intended to be reflected by the measurement point of the target sample; -a unit for computing the piece of polarisation information on the measurement point using the beam reflected by the target sample; -a waveguide for guiding the incident beam towards the target sample and the reflected beam towards the computing means; and -a unit for rotating the polarisation, capable of rotating two orthogonal polarimetric components of the incident beam exiting the waveguide and two orthogonal polarimetric components of the reflected beam before passing through the waveguide.
    Type: Application
    Filed: January 15, 2010
    Publication date: November 10, 2011
    Applicant: Centre National De La Recherche Scientifque -CNRS-
    Inventors: Dominique Pagnoux, Frédéric Louradour, Jérôme Desroches, Alain Barthelemy, Julien Brevier
  • Publication number: 20110217307
    Abstract: The present invention relates to chimeric peptides having a caveolin-1 binding domain of an HIV-1 gp41 (CBD1) peptide or a variant of said CBD1, fused to a T helper epitope. In one aspect, the T epitope is from a peptide selected from the group consisting of a tetanus toxin, an HIV-1 Gag p24 and an HIV-1 Env-gp120. Compositions containing these chimeric peptides and pharmaceutical and immunogenic compositions as well as vaccines comprising these chimeric peptides also are part of the present invention. Methods to induce neutralizing antibodies against HIV-1 activity and uses of the chimeric peptides to treat or to prevent HIV-1 infection are also disclosed.
    Type: Application
    Filed: August 27, 2009
    Publication date: September 8, 2011
    Applicant: Centre National de la Recherche Scientifque (CNRS)
    Inventors: Ara Hovanessian, Bernard Krust
  • Publication number: 20110142741
    Abstract: A method for growing crystals in solution is suitable for the rapid, controlled and effective preparation of crystals of large dimensions from a solution supersaturated with a compound. The crystal growth is carried out under static conditions. To do this: the growth is performed in a crystallisation chamber kept at a constant temperature Tc, which chamber is in fluid communication with a saturation chamber at a temperature Ts, similarly constant and different from Tc, with solubility of the compound at the temperature Ts greater than the solubility of the compound at the temperature Tc. A continuous circulation of the solution between the crystallisation and saturation chambers is established, thus maintaining a constant supersaturation rate within the crystallisation chamber. Furthermore, the circulating solution is subjected to a treatment for eliminating and inhibiting the formation of aggregates, enabling the nucleation of parasitic crystallites to be inhibited.
    Type: Application
    Filed: December 3, 2007
    Publication date: June 16, 2011
    Inventors: Alain Jean Theodore Ibanez, Julien Raphael Zaccaro
  • Patent number: 7955838
    Abstract: The present invention relates to methods and devices for adhering cells in a specific and predetermined position with an adhesive control of internal cell organization, methods for preparing such devices, methods for studying modifications of cell shape and global internal cell organization such as the distribution of cellular compartments, centrosome centering, spindle orientation, internal compartmentalization and internal transports, methods for screening compounds of interest which enhance or inhibit specific cell functions.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: June 7, 2011
    Assignees: Institut Curie, Centre National de la Recherche Scientifque
    Inventors: Michel Bornens, Manuel Thery, Matthieu Piel
  • Publication number: 20110028411
    Abstract: The invention relates to ?-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the ?-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize ?-galactoceramide analogs by a mere metathesis reaction. The ?-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
    Type: Application
    Filed: October 18, 2007
    Publication date: February 3, 2011
    Inventors: Didier Dubreuil, Muriel Pipelier, Laurent Micouin, Thomas Lecourt, Vivien Lacone, Marc Bonneville, Jacques Lependu, Anne-Laure Turcot-Dubois
  • Publication number: 20100256928
    Abstract: A medium is equipped with sources adapted for emitting a wave and sensors adapted for receiving the wave emitted. The method for locating an appearance of a defect in the medium comprises an initialisation step in which reference impulse responses of the wave between the sources and sensors are determined, then at least one defect detection step in which the impulse responses of the wave between the sources and the sensors are measured, a decorrelation coefficient between the impulse responses and the reference impulse responses is calculated, a probability of exploration of a position is calculated, an error function for each source-sensor pair is calculated, and a product of at least some of the error functions of the source-sensor pairs is calculated. The product represents a map of a probability of the appearance of the defect at each position in the medium.
    Type: Application
    Filed: February 1, 2010
    Publication date: October 7, 2010
    Inventors: Eric Francois Larose, Vincent Bruno Robert Rossetto-Giaccherino
  • Publication number: 20100236706
    Abstract: The invention provides a method of fastening lamellae of a lamellar material that is at least partially conductive onto an insulating substrate (2) containing oxides that are suitable for dissociating into mobile ions of given charge and stationary ions of opposite charge, the method comprising the steps of: placing a sample (1) of the lamellar material against a surface of the substrate; causing the oxides of the substrate to dissociate; and subjecting the substrate and the sample to an electric field by means of an electrode in contact with the substrate and an electrode in contact with the sample.
    Type: Application
    Filed: October 3, 2008
    Publication date: September 23, 2010
    Inventors: Abhay Shukla, Javed Mazher
  • Patent number: 7632514
    Abstract: The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: December 15, 2009
    Assignees: Institute Curie, Centre National de la Recherche Scientifque, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie (Paris VI)
    Inventors: Ludger Johannes, Eric Tartour, Bruno Goud, Wolf Herve Fridman