Patents Assigned to Centre Nationale de la Recherche Scientifique (CNRS)
  • Publication number: 20200088712
    Abstract: The present invention concerns an in vitro process for diagnosing joint disease in a mammal and/or determining the type of joint disease and/or determining the stage of said disease and/or predicting the course of said disease, comprising the following steps: a) depositing a drop of a synovial fluid sample from said mammal onto a flat substrate made of an inorganic material, such as glass; b) drying the drop deposited in step a); c) measuring at least one parameter indicative of the morphological features of the drop dried in step b), whereby a value for said parameter is obtained, and d) comparing each value measured in step c) with a reference value representative of a reference synovial fluid, characterized in that said parameter is selected from (i) the maximum height (H) of the bead formed on the surface of the drop, (ii) the area of the drop and (iii) the surface profile (Z) of the drop.
    Type: Application
    Filed: November 22, 2017
    Publication date: March 19, 2020
    Applicants: ECOLE CENTRALE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE D'INGENIEURS DE SAINT ETIENNE, INSTITUTENSEIGNEMENT SUPERIEUR ET RECHERCHE EN ALIMENATION, SANTE ANIMALE, AGRONOMIQUES ET
    Inventors: Catherine BOSSER, Thierry HOC, Caroline BOULOCHER
  • Patent number: 10583114
    Abstract: The present invention relates to a composition comprising urolithin A, urolithin B, urolithin C, urolithin D, or a combination thereof, for the stimulation of insulin secretion, and to the use of a compound chosen among urolithin A, urolithin B, urolithin C, urolithin D, or a combination thereof, intended for the stimulation of insulin secretion. The present invention also relates to a composition comprising an effective amount of urolithin B, urolithin C, urolithin D, or a combination thereof, for the treatment or the prevention of diabetes mellitus, and in particular for the treatment or the prevention of type 2 diabetes, and to the use of a compound chosen among urolithin B, urolithin C, urolithin D, and a combination thereof, intended for the treatment or the prevention of diabetes mellitus, and in particular of type 2 diabetes.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: March 10, 2020
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier, University of Parma, Ecole Nationale Superieure de Chimie, Centre National de la Recherche Scientifique, Universite de Montpellier
    Inventors: Gerard Cros, Alan Crozier, Margherita Dall'asta, Daniele Del Rio, Richard Magous, Catherine Oiry
  • Publication number: 20200071646
    Abstract: The present invention concerns a module for a photobioreactor suitable for being assembled to an identical adjacent module, comprising: —a panel having a first face and a second face, opposite the first face, the first face delimiting, with the second face of the adjacent panel, a cavity suitable for containing a culture medium when the modules are assembled, the cavity (14) having a thickness of between 1 millimetre and 2 centimetres, and —a gas injection device, capable of injecting gas bubbles into the culture medium contained in the cavity, such that the bubbles rise along the faces of the panels.
    Type: Application
    Filed: November 24, 2017
    Publication date: March 5, 2020
    Applicants: Centre National de la Recherche Scientifique (CNRS), Universite De Nantes, Ecole Nationale Superieure De Chimie De Clermont-Ferrand
    Inventors: Jérémy Pruvost, Jack Legrand, Jean-Francois Cornet
  • Publication number: 20190392612
    Abstract: The invention relates to a process for determining an infiltration profile of biological cells of interest in a biological object of interest from a digital histopathological image of biological tissues, a histological stain having previously been applied to the biological tissues, comprising generating a biological cell detection image, pixels associated with the histological stain on the histopathological image being of a predetermined color on said image, determining a distance map comprising distance iso-curves to the boundary of the biological object, and, from the distance map, calculating a curve representative of the surface density of biological cells of interest as a function of distance to the boundary, by counting, for each boundary distance value, pixels that are both of the predetermined color on the detection image and located between the iso-curve associated with said distance value and the consecutive iso-curve.
    Type: Application
    Filed: June 4, 2019
    Publication date: December 26, 2019
    Applicants: Centre National de la Recherche Scientifique (CNRS), Universite Paris Descartes, Ecole Nationale Superieure de Chimie de Paris, Assistance Publique-Hopitaux de Paris, Universite De Versailles-St Quentin En Yvelines, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Kathia Lemdani, Johanne Seguin, Armand Tiede Djiro, Jean-Francois Emile, Camille Kurtz, Nicolas Lomenie
  • Patent number: 10401161
    Abstract: The present invention relates to a method for dimensioning a turbomachine comprising a casing and a disc to which at least one blade is secured, said disc being rotationally driven by a shaft about a turbomachine axis (z), comprising: —acquisition (E1) of the coordinates (P) of the ends of the leading edge and of the trailing edge of the blade in a frame of reference connected with the disc; —expression (E2) of the coordinates (P?) of the ends of the leading edge and of the trailing edge of the blade in a frame of reference connected with the casing; —calculation (E3) of the distance (g) between the casing and the ends of the leading edge and trailing edge of the blade from the coordinates (P?) expressed in the frame of reference connected with the casing; —calculation (E4) of the contact pressures between the blade and the casing along the end of the blade from the calculated distance (g); —calculation (E5) of the reaction forces and moments resulting from contact between the blade and the casing from the ca
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: September 3, 2019
    Assignees: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE CENTRALE DE LYON, ECOLE NATIONALE D'INGENIEURS DE SAINT ETIENNE
    Inventors: Marie-Oceane Parent, Fabrice Joel Luc Chevillot, Fabrice Hugues Jean Pierre Thouverez
  • Publication number: 20190256754
    Abstract: A coolant mixture including water and at least one of the compounds chosen from 1-methoxy-2-propanol and 1-ethoxy-2-propanol in the proportions of the corresponding azeotrope or in near-azeotropic proportions. Such a mixture can be used as a heat-transfer fluid in a heat-exchange device, which can be incorporated into an aircraft or spacecraft. A method for obtaining a mixture by fractional distillation is also disclosed.
    Type: Application
    Filed: June 15, 2017
    Publication date: August 22, 2019
    Applicants: Safran Electrical & Power, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL POLYTECHNIQUE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE
    Inventors: Nicolas DELALANDRE, Benjamin Roland Stanislas JOOSSEN, Jean-Marie AUBRY, Vincent GERBAUD, Ivonne RODRIGUEZ-DONIS
  • Publication number: 20190247551
    Abstract: The present invention relates to an efficient method for grafting a properties-imparting compound onto a polymeric substrate containing carbon-hydrogen (C—H) bonds using clip chemistry. The method of the invention includes coating the substrate with the properties-imparting compound and irradiating it with a reactive light source, and repeating this sequence at least once. The present invention further relates to surface-modified polymeric substrates grafted with a properties-imparting compound, in particular obtained with the method of the invention, medical devices comprising same, and non-medical of said surface-modified polymeric substrates.
    Type: Application
    Filed: June 23, 2017
    Publication date: August 15, 2019
    Applicants: Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier, Ecole Nationale Superieure de Chimie de Montpellier - ENSCM
    Inventors: Benjamin Nottelet, Anita Schulz épouse Luxenhofer, Jean Coudane
  • Publication number: 20190233699
    Abstract: The present invention relates to a cooling mixture comprising a fluorinated compound and a non-fluorinated compound, wherein the fluorinated compound is a hydrofluoroether and the non-fluorinated compound includes a carbonyl function, which has a flash point no lower than 23° C. and which is characterised by having low relative volatility. The present invention likewise relates to the use of such a mixture as a coolant in a heat-exchange device.
    Type: Application
    Filed: June 15, 2017
    Publication date: August 1, 2019
    Applicants: Safran Electrical & Power, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL POLYTECHNIQUE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE
    Inventors: Nicolas DELALANDRE, Benjamin Roland Stanislas JOOSSEN, Jean-Marie AUBRY, Vincent GERBAUD, Ivonne RODRIGUEZ-DONIS
  • Publication number: 20190192430
    Abstract: The present invention relates to gelling compositions, which changes from liquid state to gel state in function of temperature comprising: at least a poloxamer or mixture of poloxamers; at least a gelling agent; and at least an anticancer agent. Said compositions are advantageously used for local administration of an anticancer agent. Said compositions are useful for size-reduction of a tumour before surgical removal of said tumour, for preventing tumour recurrence after surgical removal of a tumour, and/or treating small tumours. They are therefore useful for the treatment of cancer, preferably a cancer of a wall of the digestive system or a gynaecologic cancer. The present invention also relates to a method for preparing said gelling compositions.
    Type: Application
    Filed: September 16, 2016
    Publication date: June 27, 2019
    Applicants: Centre National de la Recherche Scientifique (CNRS), Universite Paris Descartes, Assistance Publique-Hopitaux de Paris, Ecole Nationale Superieure de Chimie de Paris, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Nathalie Mignet, Vincent Pierre-Marie Boudy, Johanne Seguin, Daniel Scherman, Yoran Beldengrun
  • Patent number: 10271539
    Abstract: The invention provides an assay-ready frozen eukaryotic cell (stored frozen) in a composition that includes a cryopreservative and an inhibitor of xanthine oxidase, a kit containing a plurality of the assay-ready frozen eukaryotic cell, and a method of preparation thereof to minimize the variability in the performance of the cell, particularly in terms of undesirable intra- and inter-assay variability.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: April 30, 2019
    Assignees: LE CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (CNRS), BIOMONITOR LIMITED
    Inventors: Michael G. Tovey, Christophe Lallemand
  • Publication number: 20160124286
    Abstract: According to a first aspect, the invention relates to a generator of at least three coherent laser beams at least one beam of which is in the infrared domain and at least one beam of which is in the visible domain, comprising: an elementary source for emitting a first continuous-wave laser beam, at a first given infrared wavelength; a nonlinear crystal frequency doubler, allowing, from a first beam sampled from the first laser beam at the first wavelength, a second laser beam to be generated at a second wavelength; and a nonlinear crystal sum frequency generator, allowing, from a second beam sampled from the first laser beam at the first wavelength and from the second laser beam at the second wavelength, a third laser beam to be generated at a third wavelength.
    Type: Application
    Filed: April 15, 2014
    Publication date: May 5, 2016
    Applicants: Observatoire De Paris, Centre Nationale de la Recherche Scientifique - CNRS
    Inventors: Mohand Ouali Acef, Frédéric Du Burck, Noël Dimarcq
  • Patent number: 9052454
    Abstract: According to one aspect, the invention relates a spectral band-pass filter, which is optimized for the transmission of an incident wave at at least a first given central wavelength ?0, and which includes: a metal grating having a thickness (t) greater than approximately ?0/50 and including at least a first set of substantially identical, parallel slots having a width (W) less than around ?0/10, and being spaced apart periodically or quasi-periodically according to a first period that is less than said first central wavelength, a layer of dielectric material having a thickness (h) and a given refractive index (ng), which is coupled to the metal grating to form a waveguide for the waves diffracted by the grating, said first period of the grating being designed such that only orders 0 and ±1 of a wave having normal incidence and a wavelength ?0 are diffracted in the layer of dielectric material, the assembly of the dielectric layer and grating being suspended, during use, in a fluid having a refractive index of
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: June 9, 2015
    Assignees: Centre Nationale de la Recherche Scientifique-CNRS, Office National d'Etudes et de Recherches Aérospatiales-ONERA
    Inventors: Grégory Vincent, Riad Haidar, Stéphane Collin, Jean-Luc Pelouard
  • Patent number: 7270671
    Abstract: The present invention provides an implantable device for semiautomatic suturing using a surgical thread, the suturing enabling biological and/or artificial tissues to be united, the device comprising: blocking means enabling two strands of the thread of a suture to be connected together in a blocking zone; a bearing element having a bearing surface for bearing against the tissues to be sutured together; and controlled tensioning means for applying controlled tensioning to said thread, and suitable, after the two strands of said thread have been blocked together using said blocking means, for exerting a tension at a first predetermined tension value, with the junction between said bearing element and said blocking zone of the device being provided by said controlled tensioning means.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: September 18, 2007
    Assignees: Unversite de la Mediterranee (Aix-Marseille II), Centre Nationale de la Recherche Scientifique (CNRS)
    Inventors: Jean Fuseri, Yves Alimi, Frédéreic Mouret, Vincent Garitey, Régis Rieu
  • Patent number: 5514807
    Abstract: The present invention relates to new noncentrosymmetric crystal structures consisting of an optionally substituted 2-amino-5-nitropyridinium halide.It also relates to a process for the preparation of these crystal structures. Finally, it relates to a device with an electro-optical effect comprising said crystal structure.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: May 7, 1996
    Assignees: France Telecom, Centre Nationale de la Recherche Scientifique (CNRS)
    Inventors: Jacques Pecaut, Jean-Pierre Levy, Rene Masses, Joseph Zyss, Rolland Hierle
  • Patent number: 4808488
    Abstract: A hybrid superconductive fiber or strand comprises at least two layers surrounding a core wherein the fiber or strand comprises two superconductive materials. One of the superconductive materials is a Chevrel phase, optionally doped, which constitutes one of the layers or the core. The other superconductive material, other than the Chevrel phase, constitutes another layer, optionally lacunar, or the core.
    Type: Grant
    Filed: May 22, 1987
    Date of Patent: February 28, 1989
    Assignee: Centre Nationale de la Recherche Scientifique (CNRS)
    Inventors: Roger A. Chevrel, Marcel M. Sergent, Maryvonne F. Hirrien