Abstract: Mandelonitrile-.beta.-D-glucuronic acid can be produced by tritylating mandelonitrile-.beta.-D-glucoside, acetylating the obtained product, and then simultaneously detritylating and oxidizing in order to obtain mandelonitrile-.beta.-D-triacetyl glucuronic acid. This compound may then be deacetylated to obtain mandelonitrile-.beta.-D-glucuronic acid or the salt thereof.

Abstract: Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. When nitrile-containing aglycones are used sodium thiosulfate is also administered to avoid cyanide poisoning. A loading dose of glucuronide greater than 2 mMoles per kilogram body weight is first administered with additional administration of one third the initial dose each hour as long as .beta.-glucuronidase activity remains at the tumor site. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention.