Patents Assigned to CHANG GUNG MEMORIAL HOSPITAL, LINKOU
  • Publication number: 20190147136
    Abstract: A method of using machine learning algorithms in analyzing laboratory test results of body fluid to detect microbes in the body fluid includes using a body fluid detection module for analytic measurements in body fluid of a person to create biological samples; sending the biological samples of a plurality of persons and corresponding microbes infection statuses to perform machine learning algorithms to establish a microbes in body fluid prediction model; and sending data obtained from the body fluid detection of a patient for testing to the microbes in body fluid prediction model for operation and analysis in order to determine whether the microbes is present in body fluid.
    Type: Application
    Filed: November 13, 2017
    Publication date: May 16, 2019
    Applicants: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, Chang Gung University
    Inventors: Jang-Jih Lu, Chung-Chih Hung, Hsin-Yao Wang, Yi-Ju Tseng
  • Patent number: 10272086
    Abstract: Methods for treating androgen receptor related diseases and suppressing androgen receptor related function by administering an effective amount of minoxidil are provided. Methods for treating or prophylactically treating acne by administering an effective amount of minoxidil are also provided. An anti-acne medication is optionally administered to treat or prophylactically treat acne.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: April 30, 2019
    Assignees: Chang Gung Memorial Hospital, Linkou
    Inventor: Cheng-Lung Hsu
  • Publication number: 20190012430
    Abstract: A method of creating characteristic peak profiles of mass spectra and identification model for analyzing and identifying microorganisms are provided. MALDI-TOF MS data of microorganisms having the same feature are gathered. Discretization of the data is performed. Density-based clustering is used to find m/z values of spectral peaks with high probability of occurrence from the discretized data. A characteristic MS peak profile is created for every specific feature of microorganisms. Every such a characteristic profile forms a feature template. The mass spectrum of each known isolate is matched against all the feature templates and a number of matched vectors are obtained. The matched vectors are then concatenated into a single “integrated vector.” Then, a machine learning method and the integrated vectors generated from all known isolates are used to create a classification model for microorganism identification.
    Type: Application
    Filed: July 10, 2017
    Publication date: January 10, 2019
    Applicants: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, Chang Gung University
    Inventors: JANG-JIH LU, CHUN-HSIEN CHEN, HSIN-YAO WANG, TSUI-PING LIU
  • Publication number: 20180344326
    Abstract: A method for designing an instrument for orthopedic surgery includes obtaining imaging information associated with a bone segment of a subject and an implant fastened to the bone segment, creating a bone segment model and an implant model based on the imaging information associated with the bone segment and the implant, and generating information regarding a shape of an instrument based on the bone segment model and the implant model. The instrument is to be disposed on the bone segment and the implant. The instrument is formed with a path to align a positioning component with a location of the bone segment which is not covered by the implant and at which the positioning component is to engage the bone segment.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 6, 2018
    Applicants: Chang Gung Memorial Hospital, Linkou, National Taiwan University of Science and Technology
    Inventors: Yi-Sheng Chan, Chi-Pin Hsu, Shang-Chih Lin, Shih-Sheng Chang
  • Patent number: 10052133
    Abstract: A Kirschner wire fixation structure, including: at least two joint elements, each having a plurality of through-hole passages extending in different directions; and at least one connection rod; wherein the plurality of through-hole passages of the at least two joint elements are for at least two Kirschner wires and the at least one connection rod to fit through respectively, the at least two Kirschner wires are for inserting into at least one bone, and the at least one connection rod is for connecting with the at least two joint elements to form a fixation structure outside the at least one bone to stabilize and hold the at least two Kirschner wires in place.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: August 21, 2018
    Assignees: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, MING CHI UNIVERSITY OF TECHNOLOGY
    Inventors: Hsuan-Kai Kao, Chih-Chung Hu
  • Patent number: 10004844
    Abstract: The present invention relates to a fat graft injection device, which comprises: an injection unit having a connection end and a terminal; The injection unit is operated by robotic arm system in controlled speed, multiple layers, multiple lines, a storage unit connected to the injection unit; and a pump unit connected to the storage unit, wherein the storage unit is between the injection unit and contains fat grafts. Fat grafts in the storage unit are injected into the subcutaneous layer through the injection unit by the pump unit with the guiding of navigation system, thus completing the fat graft injection, with accurate and effective, manner without exhausted back and forth surgeon's arm movement.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: June 26, 2018
    Assignee: CHANG GUNG MEMORIAL HOSPITAL, LINKOU
    Inventor: Ming-Huei Cheng
  • Patent number: 9885044
    Abstract: The present invention provides methods of inhibiting or reducing the growth of cancer cells in a subject, by administering a therapeutic effective amount of Puf-A inhibitor, whereby the symptoms and signs of cancer in the subject are reduced. Also provided are polynucleotides and vectors encoding the shRNAs which target Puf-A expression, which are useful for the treatment of cancer.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 6, 2018
    Assignee: Chang Gung Memorial Hospital, Linkou
    Inventors: John Yu, Huan-Chieh Cho, Alice Yu
  • Patent number: 9840563
    Abstract: Disclosed herein is a method for treating and/or preventing atrial fibrillation in a subject, comprising administering to the subject a pharmaceutical composition comprising an anti-CD44 neutralizing antibody or an antigen binding portion thereof which specifically binds to the amino-terminal domain of CD44. The anti-CD44 neutralizing antibody is a monoclonal antibody. The pharmaceutical composition further includes a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 12, 2017
    Assignee: Chang Gung Memorial Hospital, Linkou
    Inventors: Wei-Jan Chen, Yung-Hsinn Yeh, Shang-Hung Chang
  • Patent number: 9823318
    Abstract: In a method for correlating magnetic resonance images with histological sections, a target tissue of a living animal is embedded in an enclosed matrix of an optical cutting temperature compound to obtain a packaged specimen on a platform oriented in a first guiding plane. The packaged specimen on the platform is subjected to an MRI examination by scanning along imaging planes parallel to the first guiding plane, and then subjected to a frozen sectioning procedure along sectioning planes in parallel with a second guiding plane which is parallel to the first guiding plane.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: November 21, 2017
    Assignee: Chang Gung Memorial Hospital, Linkou
    Inventors: Yu-Chun Lin, Jiun-Jie Wang, Chun-Chieh Wang, Yi-Ping Lin, Gigin Lin
  • Patent number: 9724385
    Abstract: The present invention is directed toward pharmaceutical compositions comprising an isolated polypeptide and a pharmaceutically acceptable carrier. The present invention also discloses an antibody or an antigen-binding portion thereof that bind to the isolated polypeptide. Methods of inhibiting cancer cells growth are also disclosed, comprising administering the isolated polypeptide or the antibody described herein to a subject in need thereof.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 8, 2017
    Assignee: Chang Gung Memorial Hospital, Linkou Branch
    Inventors: Tzu-Hao Wang, Chia-Lung Tsai, Angel Chao
  • Patent number: 9612241
    Abstract: The present disclosure provides an optical readout imaging system may include first electrode, a thin film disposed on the first electrode, a biomolecule transfer layer disposed on the thin film, and a second electrode disposed on the biomolecule transfer layer. The present disclosure also provides a biochemical detection method using the optical readout imaging system.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 4, 2017
    Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, CHANG GUNG MEMORIAL HOSPITAL, LINKOU
    Inventors: Pai-chien Chou, Bo-Wen Xiao, Ming-Hua Yeh, Sin-Huei Wu
  • Patent number: 9371107
    Abstract: A stepper comprising: a direction controller having a front wheel set and a steering wheel connected to the front wheel set; a rear wheel transmission having a gear transmission and a rear wheel shaft, the gear transmission having an active gear, a chain and a passive gear, the active gear connected to the passive gear via the chain, the rear wheel shaft having a rear wheel set and connected to the passive gear; a supporting shaft connected to the direction controller and the rear wheel transmission; and a foot-hand swinging set having a pedal and a joystick having a handle, the pedal mounted on two sides of the supporting shaft, one end of the pedal connected to the active gear, the joystick connected to another end of the pedal. The present invention can be propelled by only single leg, and can be rehabilitation and locomotion apparatus.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: June 21, 2016
    Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, LINKOU
    Inventors: Shu-Chun Huang, May-Kuen Wong
  • Publication number: 20150276733
    Abstract: The present disclosure provides an optical readout imaging system may include first electrode, a thin film disposed on the first electrode, a biomolecule transfer layer disposed on the thin film, and a second electrode disposed on the biomolecule transfer layer. The present disclosure also provides a biochemical detection method using the optical readout imaging system.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 1, 2015
    Applicants: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, CHANG GUNG MEMORIAL HOSPITAL, LINKOU
    Inventors: Pai-chien CHOU, Bo-Wen XIAO, Ming-Hua YEH, Sin-Huei WU
  • Patent number: 9145449
    Abstract: The present invention is directed toward pharmaceutical compositions comprising an isolated polypeptide and a pharmaceutically acceptable carrier. The present invention also discloses an antibody or an antigen-binding portion thereof that bind to the isolated polypeptide. Methods of inhibiting cancer cells growth are also disclosed, comprising administering the isolated polypeptide or the antibody described herein to a subject in need thereof.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 29, 2015
    Assignee: CHANG GUNG MEMORIAL HOSPITAL, LINKOU BRANCH
    Inventors: Tzu-Hao Wang, Chia-Lung Tsai, Angel Chao
  • Publication number: 20140220025
    Abstract: The present invention is directed toward pharmaceutical compositions comprising an isolated polypeptide and a pharmaceutically acceptable carrier. The present invention also discloses an antibody or an antigen-binding portion thereof that bind to the isolated polypeptide. Methods of inhibiting cancer cells growth are also disclosed, comprising administering the isolated polypeptide or the antibody described herein to a subject in need thereof.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Applicant: Chang Gung Memorial Hospital, Linkou Branch
    Inventors: Tzu-Hao Wang, Chia-Lung Tsai, Angel Chao