Abstract: Given longstanding problems with patient engagement across the continuum of care and the need to address growing health disparities, individualized assessments represent an important element in clinical interventions. The present method (and system that executes this method) is a novel procedure that employs idiographic techniques, an n-tier cross-platform architecture, and system features that automatically and quickly generate individualized patient assessment data for use in clinical interventions.

Abstract: Infectious diseases have been sources of large-scale epidemics and pandemics resulting in millions of casualties worldwide. Detection of these biological agents normally involves several lab processes including sample preparation, nucleic acid separation and amplification, and diagnostic analysis. These steps, either performed manually or automated by high-throughput machinery, are tedious, expensive, and highly susceptible to cross-contamination. The present system is an integrated lab-on-a-device designed, developed, and tested in compatibility with a mechanical fixture for sample-to-answer biological analysis of infectious diseases.

Abstract: A system is disclosed that includes a holder having a pressurized chamber and configured to secure an aerosol delivery device at least partially within the pressurized chamber. A test chamber is connected to the holder, the test chamber having an inlet allowing an aerosol from the aerosol delivery device to enter the test chamber.

Abstract: Presented herein are MCT4 inhibitors and uses thereof for treating cancer.

Abstract: The invention provides methods, compositions, uses of compositions, assays and kits for modulating brown adipose tissue (BAT) in animals and patients with obesity, insulin resistance and perturbed glucose homeostasis are disclosed. Accordingly, methods, compositions, uses of compositions, and kits are useful for the amelioration of pathological conditions characterized by storage of excess energy, insulin resistance and related metabolic syndromes often associated with obesity.

Abstract: Provided herein are novel nucleic acid sequences, vectors comprising such nucleic acid sequences, host cells comprising such vectors, and transgenic animals comprising such nucleic acid sequences, and related molecules and methods relating thereto. Such novel nucleic acid sequences, vectors comprising such nucleic acid sequences, host cells comprising such vectors, and transgenic animals comprising such nucleic acid sequences, and related molecules and methods provide conditional overexpression of genes, such as myostatin, and transgenic animals conditionally overexpression genes, such as myostatin.