Abstract: In accordance with various aspects of the invention, CXCR4 antagonists may be used to treat hematopoietic cells, such as progenitor or stem cells, to promote the rate of cellular multiplication, self-renewal, proliferation or expansion. CXCR4 antagonists may be used therapeutically to stimulate hematopoietic stem/progenitor cell multiplication/self-renewal.
Type:
Grant
Filed:
September 20, 2004
Date of Patent:
October 14, 2008
Assignees:
Chemokine Therapeutics Corp., The University of British Columbia
Inventors:
Christopher R. Tudan, Ahmed Merzouk, Lakhdar Arab, Geeta Saxena, Connie J. Eaves, Johanne Cashman, Mary A. Richter, legal representative, Michael Clark-Lewis, legal representative, Hassan Salari, Ian Clark-Lewis
Abstract: The present disclosure teaches analogs of human chemokines and methods of using them in the prevention, treatment, and ameliorization of diseases that can benefit from therapeutic angiogenesis. The teachings are generally directed to compositions comprising SDF-1 mimetics, as well as methods that include the use of SDF-1 mimetics to induce neo-vessel formation. The disclosure also teaches articles of manufacture that can be useful in practicing the methods taught herein.
Type:
Grant
Filed:
March 24, 2006
Date of Patent:
May 6, 2008
Assignee:
Chemokine Therapeutics Corp.
Inventors:
Ahmed Merzouk, Carolina Abramovich, Hassan Salari