Abstract: Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 ?m, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
Abstract: Powdery pharmaceutical compositions including an active ingredient and carrier particles containing only a small amount of lubricant, 0.1-0.5% by weight, are used to prepare dry powder inhalers in order to increase the fine particle dose. A process for coating the surface of the carrier particles with such little amount of lubricant is also provided. Use of limited amount of lubricant is safe and provides ordered stable mixtures without segregation of the active particles during handling and before use.
Type:
Grant
Filed:
June 26, 2000
Date of Patent:
March 4, 2003
Assignee:
Chiesi Farmaceutical S.p.A.
Inventors:
Rossella Musa, Paolo Ventura, Paolo Chiesi
Abstract: Left ventricular dysfunction is treated by a process, comprising:administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of 5,6-dihydroxy-2-methylaminotetralin, or 5,6-diisobutyroyl-oxy-2-methyl-aminotetralin, or a pharmaceutically acceptable salt thereof in combination with an angiotensin-converting enzyme inhibitor.
Type:
Grant
Filed:
June 9, 1999
Date of Patent:
August 15, 2000
Assignee:
Chiesi Farmaceuticals S.p.A.
Inventors:
Paolo Chiesi, Stefano Bongrani, Roberta Razzetti, Maurizio Civelli, Alberto Umile