Patents Assigned to Children's Hospital Medical Center
  • Publication number: 20190160267
    Abstract: A ventricular catheter assembly including a proximal catheter and a cooperating cranial cover. The cranial cover includes a base plate having an opening aligned with a burr hole in the skull of a person. A guide extends upwardly from the base plate and receives the proximal catheter.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 30, 2019
    Applicant: Children's Hospital Medical Center
    Inventors: Sudhakar Vadivelu, Kelsey Radabaugh, Heather Smith, Michael Woeste, Brandon Heckman
  • Patent number: 10294517
    Abstract: Methods and compositions disclosed herein generally relate to determination of susceptibility to eosinophilic esophagitis, asthma, and/or allergic diseases, disorders, and/or pulmonary and/or upper gastrointestinal conditions arising therefrom and/or related thereto and the diagnosis, treatment, and/or management of eosinophilic esophagitis, asthma, and/or allergic diseases, disorders, and/or pulmonary and/or upper gastrointestinal conditions arising therefrom and/or related thereto. Embodiments of the invention relate to the association between genes and specific polymorphisms of genes with eosinophilic esophagitis. Embodiments of the invention can be used to determine and manage patient risk factors for development of eosinophilic esophagitis; this determination can then be used to diagnose eosinophilic esophagitis and to treat a patient diagnosed with eosinophilic esophagitis.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: May 21, 2019
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Marc E. Rothenberg, Leah Kottyan, John Harley
  • Patent number: 10288612
    Abstract: Disclosed are methods of diagnosing and treating a subject with active or inactive eosinophilic esophagitis (EoE). The methods may include the steps of detecting whether a level of eosinophil lineage-committed progenitor (EoP) is elevated in a blood sample obtained from a subject, diagnosing the subject with active EoE when an EoP level in the sample is elevated above a pre-determined cut-off value and diagnosing the subject with inactive EoE when the EoP level in the sample is below a pre-determined cut-off value; and treating the subject diagnosed with active EoE. Kits related to same are also disclosed.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: May 14, 2019
    Assignee: Children's Hospital Medical Center
    Inventor: Patricia C. Fulkerson
  • Publication number: 20190133890
    Abstract: One or more techniques and/or systems are disclosed for a gastrojejunostomy tube (G-J tube) with a replaceable balloon portion. An example G-J tube can comprise a connection point that is appropriately disposed distally from the balloon portion. The connection can be used to detach a proximal portion from a distal portion of the G-J tube; and a replacement proximal portion can be attached, and the G-J tube can be moved to the desired location. The example G-J tube can comprise a jejunal tube, a gastric tube, and a balloon tube, respectively sized to dispose the distal opening in an appropriate location in the target patient. The proximal portion can comprise at least the balloon tube, the port of the gastric tube, and the port of the jejunal tube.
    Type: Application
    Filed: November 5, 2018
    Publication date: May 9, 2019
    Applicant: Children's Hospital Medical Center of Akron
    Inventors: Reinaldo Garcia-Naveiro, Todd Ponsky
  • Publication number: 20190110708
    Abstract: A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 18, 2019
    Applicant: Children's Hospital Medical Center
    Inventor: Jing XIANG
  • Patent number: 10258665
    Abstract: Disclosed are methods for identifying patients at increased risk of developing disseminated staphylococcal infection, which includes the steps of determining that the patient has a mutation in one or more genes selected from a MPDZ network gene, a CGNL1 network gene, a PRKRIR network gene, a MED26 network gene, a tight junction protein gene, or an immune modulator gene; and treating the patient for disseminated staphylococcal infection. Also disclosed are solid substrates and/or assays useful for carrying out the disclosed methods.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: April 16, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: Bruce J. Aronow, John B. Harley, Margaret Hostetter, Kenneth Kaufman
  • Patent number: 10261068
    Abstract: The methods disclosed herein relate to an improved tool incorporating platelet count into a multi-biomarker based outcome risk stratification model for evaluating mortality risk in pediatric patients having sepsis. The methods described here are useful for treating sepsis, for point of care clinical decision support, for stratifying septic shock patients based on baseline mortality risk, and for clinical trial design, among other uses.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: April 16, 2019
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventor: Hector R. Wong
  • Patent number: 10251852
    Abstract: Disclosed are compositions and methods for treating a condition characterized by a dysregulation in macrophage lipid homeostasis. The disclosed methods may include the administration of an agent selected from a PPAR? agonist, a LXR agonist, or a combination thereof. In certain aspects, the disclosed methods may be used to prevent, treat, or ameliorate conditions such as pulmonary alveolar proteinosis (PAP) and/or symptoms associated therewith.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: April 9, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: Bruce Trapnell, Tony Sallese, Brenna Carey, Takuji Suzuki
  • Publication number: 20190099435
    Abstract: A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
    Type: Application
    Filed: August 16, 2018
    Publication date: April 4, 2019
    Applicants: Children's Hospital Medical Center, The General Hospital Corporation d/b/a Massachusetts General Hospital, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Patent number: 10234518
    Abstract: An MR loop coil design incorporates a balun into the loop coil. With this approach, some components of the coil may be simultaneously part of the imaging coil and the balun. Further, with this approach the number of components used to build an MR coil may be reduced, which may result in a reduction in cost, weight and size. This MR loop coil design may also be used to build phased array coils from the smaller loop size. Such an approach may use small feeder circuit boards oriented generally perpendicular to the coil elements to reduce interactions between the feeder boards and the coils. Such feeder boards may also be made smaller than conventional feeder circuits because the integrated balun coil design may reduce the number of components needed to create balanced coils in the array.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 19, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: Wolfgang Manfred Loew, Randy Otto Giaquinto, Charles Lucian Dumoulin
  • Patent number: 10227387
    Abstract: Embodiments of the invention are directed to compositions comprising a peptide sequence, or a nucleic acid encoding the same, wherein the peptide sequence includes a receptor-binding region of apolipoprotein E (apoE), or a sequence variant or fragment thereof, for directing delivery of a given protein or therapeutic across the blood brain barrier. Embodiments of the invention are also directed to methods of using the compositions for treating or preventing a neurological disorder, disease, or symptom in a subject in need thereof.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: March 12, 2019
    Assignee: Children's Hospital Medical Center
    Inventor: Dao Pan
  • Patent number: 10221151
    Abstract: Inhibitors of EYA tyrosine phosphatase are provided herein, as well as pharmaceutical compositions and methods relating thereto.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: March 5, 2019
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventor: Rashmi Hegde
  • Patent number: 10204707
    Abstract: A method for assessing a neuropsychiatric condition (such as, but not limited to, a risk that a subject may attempt to commit suicide or repeat an attempt to commit suicide, a risk that terminally ill patient is not being care-for or treated according to the patient's true wishes, a risk that a subject may perform or repeat a criminal act and/or a harmful act, a risk of the subject having a psychiatric illness, and/or a risk of a subject feigning a psychiatric illness) may include a plurality of steps. A step may include receiving biomarker data associated from an analysis of the subject's biological sample and a step of receiving thought-marker data obtained pertaining to one or more of the subject's recorded thoughts, spoken words, transcribed speech, and writings. A step may include generating a biomarker score associated with the neuropsychiatric condition from the biomarker data.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: February 12, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: John Pestian, Tracy A. Glauser, Bruce Aronow
  • Patent number: 10195407
    Abstract: A ventricular catheter assembly including a proximal catheter and a cooperating cranial cover. The cranial cover includes a base plate having an opening aligned with a burr hole in the skull of a person. A guide extends upwardly from the base plate and receives the proximal catheter.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: February 5, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: Sudhakar Vadivelu, Kelsey Radabaugh, Heather Smith, Michael Woeste, Brandon Heckman
  • Patent number: 10174289
    Abstract: Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also disclosed are methods for using the disclosed gastric cells, gastric tissues, and/or gastric organoids derived from precursor cells.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: January 8, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: James Macormack Wells, Kyle William McCracken
  • Patent number: 10159716
    Abstract: Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (BPD).
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: December 25, 2018
    Assignee: Children's Hospital Medical Center
    Inventors: Jeffrey A. Whitsett, Machiko Ikegami
  • Patent number: 10159673
    Abstract: Disclosed are methods of alleviating or preventing one or more symptoms associated with fragile X syndrome in an individual in need thereof via administration of a therapeutically effective amount of a GABA(A) alpha 2 and/or 3 partial agonist. The one or more symptoms may include impaired functional communication, anxiety, inattention, hyperactivity, sensory reactivity, autonomic nervous system dysregulation, aberrant eye gaze, self-injury, aggression, seizures, EEG abnormalities, including but not limited to, abnormal spectral analysis, event related potentials which may include auditory and visual responses, abnormalities in cortical responses as evoked by transcranial magnetic stimulation including resting and active motor thresholds and abnormal responses in measures of cortical inhibition and excitation, aberrant impaired cognitive function, compromised daily living skills, or a combination thereof.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: December 25, 2018
    Assignee: Children's Hospital Medical Center
    Inventors: Craig Erickson, Tori Lynn Schaefer
  • Patent number: 10155985
    Abstract: A method to evaluate eosinophilic esophagitis based on information in an eosinophilic esophagitis transcriptome.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: December 18, 2018
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Marc E. Rothenberg, Carine Blanchard
  • Patent number: 10155026
    Abstract: Disclosed are methods of treating pain in a mammal, which may include the step of administering human growth hormone to a mammal in need thereof. The pain treated by the disclosed methods may be of a type caused by inflammation induced mechanical and/or thermal hypersensitivity, and may include, for example, a pain type resulting from one or more conditions selected from peripheral injury pain, post-operative pain, cutaneous inflammation, cutaneous incision, muscle incision, or chronic pain. Disease states in which the disclosed methods may be used include fibromyalgia, sickle cell anemia, epidermolysis bullosa, erythromelalgia, complex regional pain syndrome, or generalized muscle pain.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: December 18, 2018
    Assignee: Children's Hospital Medical Center
    Inventors: Michael P. Jankowski, Xiaohua Liu, John Barns Rose
  • Publication number: 20180346552
    Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increasing a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention also relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia or ?-thalassemia.
    Type: Application
    Filed: June 1, 2018
    Publication date: December 6, 2018
    Applicant: Children's Hospital Medical Center
    Inventor: Punam Malik