Patents Assigned to Children's Hospital Medical Center
  • Patent number: 11172673
    Abstract: Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: November 16, 2021
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITY OF CINCINNATI
    Inventors: Yi Zheng, Jose Cancelas
  • Patent number: 11147501
    Abstract: A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body. Alternately, a frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in a high-definition frequency band comprising frequencies greater than 70 Hz, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: October 19, 2021
    Assignee: Children's Hospital Medical Center
    Inventor: Jing Xiang
  • Publication number: 20210299144
    Abstract: A method for the treatment or the prevention of a kidney disorder is disclosed. The method involves administering an effective concentration of pregnenolone sulfate to a subject to increase cytoplasmic Ca2+ in kidney cells.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 30, 2021
    Applicants: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Steven J Kleene, Nancy K Kleene, Bradley P Dixon, Brian J Siroky
  • Patent number: 11129886
    Abstract: Disclosed herein are virus-like particle (VLP)-based bivalent vaccine compositions. The compositions may comprise a spherical retroviral Group—specific Antigen (“Gag”) protein core and at least two Ebola glycoproteins. The at least two Ebola glycoproteins may be located at the exterior surface of the spherical Gag protein core, such that the VLP-based vaccine presents at least two Ebola glycoprotein antigens. In one aspect, the at least two Ebola glycoproteins are a Zaire (EBOV) glycoprotein, and a Sudan (SUDV) glycoprotein.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: September 28, 2021
    Assignee: Children's Hospital Medical Center
    Inventors: Karnail Singh, Paul Spearman
  • Publication number: 20210283155
    Abstract: A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 16, 2021
    Applicants: Children's Hospital Medical Center, The General Hospital Corporation d/b/a Massachusetts General Hospital, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20210267557
    Abstract: A patient table adapted for use in association with an MR scanner for neonatal infants is provided. The patient table has an extendable patient bed attached to and extendable from the patient table. The patient bed may be at least partially inserted into an MR scanner without requiring the patient table to enter the MR scanner. A transport mechanism is on the underside of the patient table so that it may be readily moved over the floor on which it rests. The patient table includes a latching mechanism that may operate to releasably attach the patient table to a patient table docking assembly. The docking assembly is operative to selectively move the patient table towards, into and away from the MR scanner.
    Type: Application
    Filed: May 17, 2021
    Publication date: September 2, 2021
    Applicant: Children's Hospital Medical Center
    Inventor: Charles L. Dumoulin
  • Patent number: 11104953
    Abstract: Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in pediatric patients. In particular, the invention relates to identifying two or more biomarkers associated with septic shock in pediatric patients, obtaining a sample from a pediatric patient having at least one indication of septic shock, then quantifying from the sample an amount of two or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: August 31, 2021
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITY OF CINCINNATI
    Inventors: Hector R. Wong, Christopher John Lindsell
  • Patent number: 11103210
    Abstract: An image guided autonomous needle insertion device including a delivery system, a path planner, an image processor, and a human machine interface. The system also includes an ultrasound probe in communication with a frame grabber, a percutaneous insertion device, and at least a first actuator for moving the percutaneous insertion device within a first degree of freedom and a second actuator for moving the percutaneous insertion device within a second degree of freedom. Each actuator has a corresponding position sensor for detecting its location with respect to a target. The system can further comprise an image processor for removing noise and segmenting the ultrasound images to highlight potential targets.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: August 31, 2021
    Assignees: Children's Hospital Medical Center, B.G. Negev Technologies and Applications Ltd.
    Inventors: Daniel Von Allmen, Hugo Guterman
  • Publication number: 20210253655
    Abstract: Some embodiments of the invention include polypeptides comprising a myomerger polypeptide or an extracellular myomerger polypeptide. Other embodiments of the invention include nucleic acid molecules encoding polypeptides comprising a myomerger polypeptide or an extracellular myomerger polypeptide. Other embodiments of the invention include vectors comprising the nucleic acid molecule. Yet other embodiments of the invention include methods of using a myomerger polypeptide or an extracellular myomerger polypeptide. Additional embodiments of the invention are also discussed herein.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 19, 2021
    Applicants: CHILDREN'S HOSPITAL MEDICAL CENTER, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    Inventors: Douglas MILLAY, Dilani GAMAGE, Leonid CHERNOMORDIK, Evgenia LEIKINA
  • Publication number: 20210220445
    Abstract: Administering a pulmonary surfactant and a corticosteroid in a low dose is effective for the prophylaxis of bronchopulmonary dysplasia (BPD) in preterm neonates.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 22, 2021
    Applicants: CHIESI FARMACEUTICI S.p.A., CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Alan JOBE, Augusto SCHMIDT, Noah HILLMAN, Matthew KEMP
  • Publication number: 20210223337
    Abstract: A birdcage coil for a magnetic resonance imaging (MRI) system, the birdcage coil includes: a relatively planar birdcage coil section, including a pair of relatively planar ring portions and a plurality of conductive, elongated rungs extending between the pair of relatively planar ring portions; and a relatively domed birdcage coil section, including a pair of relatively domed ring portions and a plurality of conductive, elongated rungs extending between the pair of relatively domed ring portions. The relatively domed birdcage coil section is releasably coupled to the relatively planar birdcage coil section. In an embodiment, at least two sets of the relatively planar and domed birdcage coil sections are provided, where each of the at least two sets is configured to a different MRI application.
    Type: Application
    Filed: April 5, 2021
    Publication date: July 22, 2021
    Applicant: Children's Hospital Medical Center
    Inventors: Wolfgang Manfred LOEW, Charles Lucian DUMOULIN
  • Patent number: 11066650
    Abstract: The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of gastric fundus tissue and/or organoids formed from differentiated definitive endoderm.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: July 20, 2021
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: James Wells, Kyle McCracken
  • Patent number: 11066678
    Abstract: The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: July 20, 2021
    Assignee: Children's Hospital Medical Center
    Inventors: Johannes Van Der Loo, Punam Malik
  • Publication number: 20210213037
    Abstract: Some embodiments of the invention include methods for treating an animal for fibrosis comprising one or more administrations of one or more compositions comprising one or more AURKB (Aurora kinase B) inhibitors. Other embodiments of the methods for treating further include other fibrosis treatments. Still other embodiments of the invention include methods for treating a human for lung fibrosis or idiopathic pulmonary fibrosis, comprising administering one or more compositions comprising AZD1152 or barasertib. Additional embodiments of the invention are also discussed herein.
    Type: Application
    Filed: February 14, 2019
    Publication date: July 15, 2021
    Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Satish Kumar MADALA, Anil Goud JEGGA, Rajesh K. KASAM
  • Patent number: 11058697
    Abstract: A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: July 13, 2021
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, INSTITUTO NACIONAL DE CIENCIAS MEDICAS Y NUTRICION, THE GENERAL HOSPITAL CORPORATION
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20210204919
    Abstract: Provided herein are methods and kits for collecting and/or detecting biological materials from the skin of subjects. Methods and kits for determining a biological profile of a target skin site of subjects are also provided herein.
    Type: Application
    Filed: March 3, 2018
    Publication date: July 8, 2021
    Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Gurjit Khurana HERSHEY, Jocelyn BIAGINI-MYERS, Eric SCHAUBERGER
  • Publication number: 20210204831
    Abstract: The present disclosure relates to a transfer cart suitable for use in association with an MR scanner. The transfer cart may include a transfer table assembly coupled to the support frame such that the transfer table assembly and the horizontal support structure portion of the support frame extend substantially perpendicularly from the vertical support structure of the support frame and in substantially parallel planes to each other. The transfer table assembly may be maintained at substantially the same vertical level of a scanning bore of an MR scanner. The transfer cart may include a frame designed to dock with the MR scanner.
    Type: Application
    Filed: March 24, 2021
    Publication date: July 8, 2021
    Applicant: Children's Hospital Medical Center
    Inventor: Charles L. Dumoulin
  • Patent number: 11053477
    Abstract: Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also disclosed are methods for using the disclosed gastric cells, gastric tissues, and/or gastric organoids derived from precursor cells.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 6, 2021
    Assignee: Children's Hospital Medical Center
    Inventors: James Macormack Wells, Kyle William McCracken
  • Patent number: 11033200
    Abstract: A patient table adapted for use in association with an MR scanner for neonatal infants is provided. The patient table has an extendable patient bed attached to and extendable from the patient table. The patient bed may be at least partially inserted into an MR scanner without requiring the patient table to enter the MR scanner. A transport mechanism is on the underside of the patient table so that it may be readily moved over the floor on which it rests. The patient table includes a latching mechanism that may operate to releasably attach the patient table to a patient table docking assembly. The docking assembly is operative to selectively move the patient table towards, into and away from the MR scanner.
    Type: Grant
    Filed: July 8, 2018
    Date of Patent: June 15, 2021
    Assignee: Children's Hospital Medical Center
    Inventor: Charles L. Dumoulin
  • Patent number: 11026950
    Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 8, 2021
    Assignee: Children's Hospital Medical Center
    Inventors: Jeffrey A. Whitsett, Yutaka Maeda, Takuya Fukazawa