Patents Assigned to Childrens Hospital Medical Center Corp.
  • Patent number: 5639725
    Abstract: The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: June 17, 1997
    Assignee: Children's Hospital Medical Center Corp.
    Inventors: Michael S. O'Reilly, M. Judah Folkman
  • Patent number: 5629327
    Abstract: The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: May 13, 1997
    Assignee: Childrens Hospital Medical Center Corp.
    Inventor: Robert D'Amato