Patents Assigned to Children's Medical Center Corporation
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Publication number: 20240124557Abstract: The invention features compositions and methods for delivering antibodies to the fetal circulation to be used for preventing and/or treating a fetal alloimmune disorder and/or to treat and/or prevent perinatal infections and/or to prevent neonatal necrotizing enterocolitis.Type: ApplicationFiled: December 21, 2023Publication date: April 18, 2024Applicant: The Children's Medical Center CorporationInventor: Dario O. FAUZA
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Patent number: 11957713Abstract: The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.Type: GrantFiled: October 16, 2017Date of Patent: April 16, 2024Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, OSPEDALE SAN RAFFAELE S.R.L., POLITECNICO DI MILANO, FONDAZIONE TELETHON ETS, DANA-FARBER CANCER INSTITUTE, INCInventors: Alessandra Biffi, Marco Peviani, Davide Moscatelli, Alessia Capotondo, Rita Milazzo, Umberto Capasso Palmiero
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Publication number: 20240117437Abstract: The invention features panels of genes associated with Sudden Unexpected Death in Pediatrics (SUDP), and methods of using such panels to identify a cause of death, and to select children at risk of SUDP for therapies to treat pathologies that predispose them to SUDP.Type: ApplicationFiled: December 7, 2023Publication date: April 11, 2024Applicant: The Children's Medical Center CorporationInventor: Richard D. GOLDSTEIN
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Publication number: 20240117006Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.Type: ApplicationFiled: September 29, 2023Publication date: April 11, 2024Applicant: The Children's Medical Center CorporationInventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
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Publication number: 20240115693Abstract: Provided herein are nanoparticles which enhance the immunogenicity of antigens for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) vaccines, as well as immunogenic compositions comprising the antigen nanoparticles and additional adjuvants for further enhancing immunogenicity.Type: ApplicationFiled: June 23, 2022Publication date: April 11, 2024Applicants: Children's Medical Center Corporation, Dana-Farber Cancer Institute, Inc.Inventors: Francesco Borriello, Ofer Levy, David J. Dowling, Sirano Dhe-Paganon, Hyuk-Soo Seo
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Patent number: 11944625Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.Type: GrantFiled: February 12, 2021Date of Patent: April 2, 2024Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, DANA-FARBER CANCER INSTITUTE, INC.Inventors: James Bradner, Jun Qi, Dennis Buckley, Leonard I. Zon, Elizabeth Macari
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Publication number: 20240099592Abstract: A system includes a sensor configured to generate thoracic impedance data associated with a patient for a period of time, a memory storing machine-readable instructions, and a control system communicatively coupled to the sensor. The control system is arranged to provide control signals to one or more electronic devices and including one or more processors configured to execute the machine-readable instructions to analyze the generated thoracic impedance data associated with the patient; determine, based at least in part on the analysis, respiratory function signals and cardiac function signals, and whether the respiratory function signals and cardiac function signals satisfies a predetermined threshold, and cause an operation of the one or more electronic devices to be modified in response to determining the respiratory function signals and cardiac function signals satisfies the predetermined threshold.Type: ApplicationFiled: October 8, 2020Publication date: March 28, 2024Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Benjamin MATTHEWS, Christopher NORVE
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Publication number: 20240092845Abstract: Provided herein are methods and compositions comprising or using mutant semaphorin polypeptides.Type: ApplicationFiled: March 10, 2023Publication date: March 21, 2024Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: David M. BRISCOE, Diane BIELENBERG, Johannes WEDEL
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Publication number: 20240091405Abstract: Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally, methods and related kits for the repair of articular tissue using the collagen material are provided.Type: ApplicationFiled: November 27, 2023Publication date: March 21, 2024Applicant: The Children's Medical Center CorporationInventor: Martha M. MURRAY
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Publication number: 20240091238Abstract: The present invention relates generally to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of calmodulin inhibitors and calcium channel blockers for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA).Type: ApplicationFiled: April 7, 2023Publication date: March 21, 2024Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Leonard I. ZON, Alison M. TAYLOR
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Publication number: 20240092736Abstract: Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and/or compositions to a subject.Type: ApplicationFiled: October 29, 2020Publication date: March 21, 2024Applicant: Children's Medical Center CorporationInventors: Daniel S. Kohane, Yueqin Zheng
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Patent number: 11931023Abstract: A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.Type: GrantFiled: February 18, 2021Date of Patent: March 19, 2024Assignee: Children's Medical Center CorporationInventors: Pedro J. del Nido, Nikolay V. Vasilyev, Franz Freudenthal
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Publication number: 20240082369Abstract: Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified receptor binding domain of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations. Isolated modified receptor binding domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed.Type: ApplicationFiled: December 20, 2021Publication date: March 14, 2024Applicant: Children's Medical Center CorporationInventors: Min Dong, Pyung-Gang Lee
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Publication number: 20240082312Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.Type: ApplicationFiled: June 6, 2023Publication date: March 14, 2024Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Guoping Feng, Boaz Barak, Zhigang He
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Publication number: 20240081728Abstract: Described herein are techniques to aid clinicians and researchers in determining a condition of connective tissue as it relates to tissue development, growth and maturation, tissue remodeling and healing following injury, and risk of injury based on a magnetic resonance (MR) image of the tissue. Such techniques may be useful to clinicians by providing insights on factors that influence the growth and maturation of connective tissues as well as those that impact the risk of connective tissue injury and response to treatment. These insights can be used in a variety of ways, including to guide or develop patient specific risk assessment and prevention strategies, treatment plans, and postoperative care plans for individuals at risk of connective tissue injuries and those with injured connective tissues, such as an anterior cruciate ligament (ACL) injury.Type: ApplicationFiled: January 27, 2022Publication date: March 14, 2024Applicants: Children's Medical Center Corporation, Rhode Island HospitalInventors: Ata Kiapour, Braden C. Fleming, Martha M. Murray
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Publication number: 20240076382Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.Type: ApplicationFiled: July 19, 2023Publication date: March 7, 2024Applicants: Pfizer Inc., Children's Medical Center CorporationInventors: Florian WINAU, Oleg V. KOVALENKO, Chew Shun CHANG, Di WU, Nicholas Andrew MARZE, Shian-Huey CHIANG
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Publication number: 20240076715Abstract: Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte.Type: ApplicationFiled: February 13, 2023Publication date: March 7, 2024Applicant: Children's Medical Center CorporationInventors: Wesley Philip Wong, Johanna Blass, Darren Yang, Clinton H. Hansen
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Patent number: 11918773Abstract: Methods and apparatus for cleaning a central venous catheter port are disclosed. An apparatus includes a body, a coupling configured to connect the body to the hub, a cleaning cap coupled to the body, and an actuator disposed within the body for rotating and translating the cap relative to the hub. The cleaning cap includes a cap body defining a cavity and a cleaning member disposed within the cavity, the cleaning member having threads that engage with the threads on the hub.Type: GrantFiled: June 7, 2021Date of Patent: March 5, 2024Assignee: Children's Medical Center CorporationInventors: John Kheir, Pierre DuPont, Asghar Ataollahi, Sarah Ward Goldberg, Brian D. Polizzotti
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Publication number: 20240067947Abstract: Provided herein are polypeptides that are truncated modified recombinant forms of ADAMTS13, nucleic acid molecules encoding the polypeptides, drug delivery compositions and pharmaceutical compositions comprising the polypeptides, and methods of using the polypeptides and compositions (e.g., in the treatment of thrombotic thrombocytopenic purpura (TTP)).Type: ApplicationFiled: October 28, 2021Publication date: February 29, 2024Applicants: Children's Medical Center Corporation, The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Daniel S. Kohane, Juan C. Ibla, Upendra Katneni, Chava Kimchi-Sarfaty
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Patent number: 11913872Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.Type: GrantFiled: February 4, 2021Date of Patent: February 27, 2024Assignees: President and Fellows of Harvard College, Children's Medical Center CorporationInventors: Darren Yang, Andrew Ward, Wesley Philip Wong, Kenneth Anders Halvorsen