Patents Assigned to Chrono Therapeutics, Inc.
  • Publication number: 20190275308
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Application
    Filed: February 25, 2019
    Publication date: September 12, 2019
    Applicant: Chrono Therapeutics Inc.
    Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
  • Patent number: 10258738
    Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 16, 2019
    Assignee: Chrono Therapeutics Inc.
    Inventors: Guy DiPierro, Steven A. Giannos
  • Patent number: 10258778
    Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: April 16, 2019
    Assignee: Chrono Therapeutics Inc.
    Inventors: Guy DiPierro, Steven A. Giannos
  • Patent number: 10232156
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: March 19, 2019
    Assignee: Chrono Therapeutics Inc.
    Inventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
  • Patent number: 10213586
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: February 26, 2019
    Assignee: Chrono Therapeutics Inc.
    Inventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
  • Patent number: 10105487
    Abstract: Optimized bio-synchronous drug delivery begins with establishing a bio-synchronous treatment protocol that incorporates individual temporal and innate biological characteristics into a pharmacological treatment plan. The bio-synchronous treatment protocol is thereafter initiated using bioactive agent delivery device. Bio-synchronous drug delivery includes continual collection of patient data such as physical, psychological, temporal and environmental characteristics. This data is analyzed so to not only determine an initial treatment protocol but to also determining whether modification to the ongoing bio-synchronous treatment protocol is required. And, responsive to determining a modification is required the system modifies the bio-synchronous treatment protocol and use of delivery device. These modifications and treatment protocols can include reactive and proactive psychological support supplied to the patient in a variety of formats.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: October 23, 2018
    Assignee: CHRONO THERAPEUTICS INC.
    Inventors: Guy DiPierro, Alan Joel Levy
  • Publication number: 20180033330
    Abstract: A craving control device comprising a housing, a craving input actuator supported by the housing, a wireless communicator supported by the housing, and a controller is provided. The craving input actuator can be configured to obtain information from a user pertaining to a timing, frequency, or intensity of a craving. The controller can be operatively connected to the craving input actuator and the wireless communicator to communicate craving information received by the craving input actuator via the wireless communicator to a device external to the housing. The device external to the housing can be a personal communication device. The housing can be sized and configured to be enclosed in the user's hand and or to be placed in a pocket of the user's clothing Methods for using the craving control devices are also provided.
    Type: Application
    Filed: March 11, 2016
    Publication date: February 1, 2018
    Applicant: CHRONO THERAPEUTICS INC.
    Inventors: Jennifer A. DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Alan Joel LEVY
  • Patent number: 9669199
    Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: June 6, 2017
    Assignee: Chrono Therapeutics Inc.
    Inventors: Guy DiPierro, Steven A. Giannos
  • Patent number: 9555227
    Abstract: Systems and methods for synchronizing the administration of compounds with the human body's natural circadian rhythms and addiction rhythms to counteract symptoms when they are likely to be at their worst by using an automated and pre programmable transdermal or other drug administration system.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: January 31, 2017
    Assignee: CHRONO THERAPEUTICS INC.
    Inventor: Guy Dipierro
  • Patent number: 9555226
    Abstract: The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: January 31, 2017
    Assignee: CHRONO THERAPEUTICS INC.
    Inventors: Werner Zumbrunn, Georgios Imanidis, Guy Dipierro, Hans Werner Van De Venn
  • Publication number: 20140323423
    Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible.
    Type: Application
    Filed: May 2, 2014
    Publication date: October 30, 2014
    Applicant: Chrono Therapeutics, Inc.
    Inventors: Guy DiPierro, Steven A. Giannos
  • Publication number: 20140207048
    Abstract: Optimized bio-synchronous drug delivery begins with establishing a bio-synchronous treatment protocol that incorporates individual temporal and innate biological characteristics into a pharmacological treatment plan. The bio-synchronous treatment protocol is thereafter initiated using bioactive agent delivery device. Bio-synchronous drug delivery includes continual collection of patient data such as physical, psychological, temporal and environmental characteristics. This data is analyzed so to not only determine an initial treatment protocol but to also determining whether modification to the ongoing bio-synchronous treatment protocol is required. And, responsive to determining a modification is required the system modifies the bio-synchronous treatment protocol and use of delivery device. These modifications and treatment protocols can include reactive and proactive psychological support supplied to the patient in a variety of formats.
    Type: Application
    Filed: January 16, 2014
    Publication date: July 24, 2014
    Applicant: Chrono Therapeutics, Inc.
    Inventors: Guy DiPierro, Alan Joel Levy
  • Publication number: 20140207047
    Abstract: A bioactive agent delivery device having a plurality of reservoirs wherein each reservoir houses a solvent provides a means for separable and segregated delivery of bioactive agent(s) to a patient. The device can include a plurality of absorbent materials wherein each absorbent material is pretreated with a bioactive agent and a delivery mechanism operable to deliver to any of the plurality of absorbent materials a controlled portion of solvent from any of a plurality of reservoirs. A diffusion layer interposed between the absorbent materials and an epidermis transfers the bioactive agent from the absorbent materials to the epidermis for delivery of the bioactive agent.
    Type: Application
    Filed: January 16, 2014
    Publication date: July 24, 2014
    Applicant: Chrono Therapeutics, Inc.
    Inventors: Guy DiPierro, Michael Barsness, Bireswar Chakroborty, Kuowei Chang
  • Publication number: 20140200525
    Abstract: Systems and methods for synchronizing the administration of compounds with the human body's natural circadian rhythms and addiction rhythms to counteract symptoms when they are likely to be at their worst by using an automated and pre programmable transdermal or other drug administration system.
    Type: Application
    Filed: January 23, 2014
    Publication date: July 17, 2014
    Applicant: Chrono Therapeutics, Inc.
    Inventor: Guy DiPierro
  • Patent number: 8741336
    Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: June 3, 2014
    Assignee: Chrono Therapeutics, Inc.
    Inventors: Guy DiPierro, Steven A. Giannos
  • Patent number: 8673346
    Abstract: The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: March 18, 2014
    Assignee: Chrono Therapeutics, Inc.
    Inventors: Werner Zumbrunn, Georgios Imanidis, Guy DiPierro, Hans Wernher van De Venn
  • Patent number: 8440221
    Abstract: The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: May 14, 2013
    Assignee: Chrono Therapeutics, Inc.
    Inventors: Werner Zumbrunn, Hans Werner Van de Venn, George Imanidis, Guy DiPierro
  • Patent number: 8372040
    Abstract: A device for transdermal drug delivery and administration of differing dosages at specific times of the day automatically pursuant to a pre-programmed dosage profile. The device includes a control and display unit, a two-part dispensing mechanism, a drug reservoir, an administration element, and a solvent removal element. The dispensing mechanism may be a peristaltic pump having an active portion with a motor, a roller, a mounting plate and a detachable passive portion with tubing and a housing. The motor and roller are mounted in the reusable portion of the delivery device with the control unit and a power source. The speed of the micromotor is controlled by the control unit, so that the turning speed of the roller is controlled which, in turn, controls the flow rate to the administration. The passive portion and drug reservoir are detachable along with the administration element for attaching a new dosing reservoir.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: February 12, 2013
    Assignee: Chrono Therapeutics, Inc.
    Inventors: Joseph Zhili Huang, Guy DiPierro
  • Patent number: 8252321
    Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 28, 2012
    Assignee: Chrono Therapeutics, Inc.
    Inventors: Guy Dipierro, Steven A. Giannos
  • Patent number: RE46217
    Abstract: A device for transdermal drug delivery and administration of differing dosages at specific times of the day automatically pursuant to a pre-programmed dosage profile. The device includes a control and display unit, a two-part dispensing mechanism, a drug reservoir, an administration element, and a solvent removal element. The dispensing mechanism may be a peristaltic pump having an active portion with a motor, a roller, a mounting plate and a detachable passive portion with tubing and a housing. The motor and roller are mounted in the reusable portion of the delivery device with the control unit and a power source. The speed of the micromotor is controlled by the control unit, so that the turning speed of the roller is controlled which, in turn, controls the flow rate to the administration. The passive portion and drug reservoir are detachable along with the administration element for attaching a new dosing reservoir.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: November 29, 2016
    Assignee: CHRONO THERAPEUTICS INC.
    Inventors: Joseph Zhili Huang, Guy DiPierro