Patents Assigned to École Polytechnique Fédérale de Lausanne
  • Publication number: 20220127310
    Abstract: Aerolysin polypeptides and/or mutant aerolysin monomers include modified amino acid sequences that could have improved substrate analyte, such as (poly)nucleotide and peptide, improved reading properties such as enhanced substrate analyte capture and improved substrate analyte recognition and/or discrimination. Also, aerolysin pores may be derived from the mutant monomers as well as apparatuses and devices may include modified aerolysin polypeptides. Further, methods of using modified aerolysin proteins and pores derive therefrom may be used in characterizing and/or sequencing a polymeric molecule or may be for use as molecular sensors.
    Type: Application
    Filed: October 28, 2020
    Publication date: April 28, 2022
    Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Matteo DAL PERARO, Chan CAO
  • Patent number: 11309896
    Abstract: A reconfigurable logic circuit comprises first, second and third switching circuits arranged for receiving first, second and third input bits, respectively, and each arranged for being configured in a mode wherein the corresponding input bit is passed on or in a mode; a first exclusive OR logic block operable on the outputs of the first, second and third switching circuits and arranged to output a sum bit; fourth, fifth and sixth switching circuits arranged for receiving a fourth, fifth and sixth input bits and arranged for being configured in a mode; first, second and third AND logic blocks, each arranged for receiving a different pair of the outputs of certain switching circuits; a second exclusive OR logic block operable on the outputs of certain AND logic blocks and arranged to produce a carry output bit.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: April 19, 2022
    Assignees: KATHOLIEKE UNIVERSITEIT LEUVEN, UNIVERSITÀ DELLA SVIZZERA ITALIANA, ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Nele Mentens, Francesco Regazzoni, Edoardo Charbon
  • Patent number: 11301750
    Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: April 12, 2022
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Henry Markram, Wulfram Gerstner, Marc-Oliver Gewaltig, Christian Rössert, Eilif Benjamin Muller, Christian Pozzorini, Idan Segev, James Gonzalo King, Csaba Erö, Willem Wybo
  • Patent number: 11298968
    Abstract: A method for marking a product (1) with a photoluminescent mark, said mark comprising a photoluminescent portion (10) which is transparent under normal light conditions and revealed by photoluminescence under UV illumination, said mark further comprising a non photoluminescent portion (9) which is transparent under normal light conditions as well s under UV illumination, said method comprising: deposing on said product a stack, said stack comprising alternatively layers (2,4) such as AlN, with a thickness of less than 1 micron and layers (3) of a second material, such as GaN with a thickness of less than 10 nm; raising the transparency of said non photoluminescent portion (10) with a deposition of transparent material (6) or incorporation of ions into said non photoluminescent portions.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: April 12, 2022
    Assignee: Ecole Polytechnique Federale de Lausanne
    Inventors: Nasser Hefyene, Nicolas Grandjean
  • Publication number: 20220109457
    Abstract: Various embodiments are directed to Reed-Muller decoding systems and methods based on recursive projections and aggregations of cosets decoding, exploiting the self-similarity of RM codes, and extended with list-decoding procedures and with outer-code concatenations
    Type: Application
    Filed: January 17, 2020
    Publication date: April 7, 2022
    Applicants: The Trustees of Princeton University, Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Min Ye, Emmanuel Abbe
  • Patent number: 11278465
    Abstract: The invention concerns an exoskeleton made of elements combined or attached together, said elements being adjustable or not and said elements being made in a sandwich construction. The invention also concerns a method to manufacture such an exoskeleton.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: March 22, 2022
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Tristan Vouga, Paul Bertusi, Mohamed Bouri
  • Publication number: 20220072892
    Abstract: The present invention proposes a method for producing an authenticable moiré shape that simultaneously moves and shows a beating effect. The method relies on a combination of the 1D or the 2D moiré and the level line moiré. When tilting a compound showing such a moiré, the moiré shape moves, its intensity levels change significantly but its shape remains the same and is recognizable. Embodiments comprise a base layer made of patterned metallic tiny shapes and a revealing layer made of a 1D array of cylindrical lenslets or of a 2D array of spherical or aspherical lenslets.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 10, 2022
    Applicant: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Thomas Walger, Roger D. Hersch, Jürgen Brugger
  • Publication number: 20220075171
    Abstract: A light microscope has a light source for illuminating a specimen, a photon-counting detector array with a plurality of photon-counting detector elements for measuring detection light coming from the specimen, wherein the photon-counting detector elements are configured to output respective measured photon count rates, and a control device for controlling the photon-counting detector array. The control device is configured to individually influence the measurable photon count rates which are simultaneously measurable with different photon-counting detector elements and/or which are consecutively measurable with the same photon-counting detector element. Furthermore, in an imaging method the measurable photon count rates of photon-counting detector elements are individually influenced to increase the signal-to-noise ratio for the photon-counting detector array.
    Type: Application
    Filed: January 25, 2019
    Publication date: March 10, 2022
    Applicants: Carl Zeiss Microscopy GmbH, Ecole Polytechnique Federale de Lausanne
    Inventors: Tiemo ANHUT, Daniel SCHWEDT, Ivan Michel ANTOLOVIC, Claudio BRUSCHINI, Edoardo CHARBON
  • Patent number: 11257974
    Abstract: The present invention relates to a solar cell comprising a heterojunction photoelectric device comprising, a front electrode layer, a back electrode layer comprising a metallic contact layer, a light-absorbing silicon layer arranged between said front electrode and said back electrode layers and a doped silicon-based layer arranged between said light-absorbing silicon layer and said back electrode layer, characterized in that said heterojunction photoelectric device further comprises a wide band gap material layer having an electronic band gap greater than 1.4 eV, said wide band gap material layer being applied on a surface of the light-absorbing silicon layer between said light-absorbing silicon layer and said doped silicon-based layer. The present heterojunction layer or stack of layers is compatible with thermal annealing and firing processes at T above 600° C.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: February 22, 2022
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Philipp Löper, Andrea Ingenito, Christophe Ballif, Gizem Nogay
  • Patent number: 11248301
    Abstract: The present invention relates to a photo-electrochemical device for production of a gas, liquid or solid using concentrated electromagnetic irradiation. The device comprises a photovoltaic component configured to generate charge carriers from the concentrated electromagnetic irradiation; and an electrochemical component configured to carry out electrolysis of a reactant. The photovoltaic component contacts the electrochemical component at a solid interface to form an integrated photo-electrochemical device; and further includes at least one reactant channel or a plurality of reactant channels extending between the photovoltaic component and the electrochemical component to transfer heat and the reactant from the photovoltaic component to the electrochemical component. The integrated photo-electrochemical device and auxiliary devices (such as concentrator, flow controllers) build a system which can flexibly react to changes in operating condition and guarantee best performance.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: February 15, 2022
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Saurabh Tembhurne, Meng Lin, Sophia Haussener
  • Patent number: 11246943
    Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: February 15, 2022
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, Stephan Kontos, Karen Y. Dane
  • Patent number: 11252352
    Abstract: The present invention relates to a pixel sensor cell (1) for a CMOS sensor device comprising: —a photodiode (11) for generating photoelectrons; —a first transfer transistor (12) coupling the photodiode (11) with an intermediate node (IN) and configured to be controlled by a first control signal (TX1); —a gain reducing capacitance (CHD) applied on the intermediate node (IN); —a second transfer transistor (14) coupling the intermediate node (IN) with a sense node (SN) and configured to be controlled by a second control signal (TX2); —an output buffer (15) coupled with the sense node (SN) and configured to amplify a potential on the sense node (SN).
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: February 15, 2022
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventor: Assim Boukhayma
  • Patent number: 11248959
    Abstract: The present disclosure concerns a multi-spectral image printing method. The method includes the steps of:—providing a multi-spectral image;—providing a material;—determining changes in a refractive index value of the material permitting to reproduce the multi-spectral image when the material is illuminated; and—generating the changes in refractive index value in the material.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: February 15, 2022
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Adam Scholefield, Martin Vetterli, Yves Bellouard, Michalina Pacholska, Gilles Baechler, Arnaud Latty
  • Publication number: 20220026379
    Abstract: MR device (100) comprising a miniaturized magnetic resonance system (101) and a cell culture chamber (502) for the analysis of biological samples of less than about 1000 ?m in size, wherein said device (100) is at least partially covered by a passivation-binding layer (800). The invention also concerns a method for manufacturing said device (100), comprising a step of depositing a thin passivation-binding layer (800) on said system (101) The depositing step is preferably performed through a deposition process selected from chemical vapor deposition and physical vapor deposition.
    Type: Application
    Filed: September 20, 2019
    Publication date: January 27, 2022
    Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Marco GRISI, Giovanni BOERO, Juergen BRUGGER, Gaurasundar Marc CONLEY
  • Patent number: 11232609
    Abstract: A method of displaying an image on a see-through display comprises: obtaining a first electro-magnetic radiation matrix of radiation intensity values of an object; dividing the first matrix into a second matrix representing a first subset of the radiation intensity values, and a third matrix representing a second subset of the radiation intensity values; generating a first grayscale image with an enhanced contrast representing the first subset of the radiation intensity values from the second matrix; colouring the first grayscale image with a first colourmap to obtain a first colour image; generating a second grayscale image representing the second subset of the radiation intensity values; colouring the second grayscale image with a second colourmap to obtain a second colour image; combining the first colour image and the second colour image; and displaying the combined colour image on the see-through display.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: January 25, 2022
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Adrien Birbaumer, Martinus Bosch, Jason Racine, Sabine Süsstrunk
  • Patent number: 11226232
    Abstract: A Multichromatic Calibration (MC) method of at least a spectral sensor which is one of a list comprising at least a spectrometer, a multispectral sensor, a hyperspectral sensor, a spectral camera, a color camera. The method comprises a. generating a plurality of different multichromatic spectra, wherein i. a spectrum from the plurality of different multichromatic spectra contains light intensity measurable by the at least one spectral sensor and by a reference spectral device, and ii. a spectrum from the plurality of different multichromatic spectra contains light centered around at least two different wavelengths and is configured to be integrated during an exposure time of a single measurement from any of the at least one spectral sensor or the reference spectral device; b.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: January 18, 2022
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Dragos Constantin, Simon De Visscher
  • Patent number: 11219703
    Abstract: The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: January 11, 2022
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Amélie Barbara Hildegarde Béduer, Thomas Braschler, Philippe Renaud, Giorgio Pietramaggiori, Saja Scherer
  • Patent number: 11211115
    Abstract: A random access memory array including a plurality of local memory group ways, each local memory group way including, a plurality of local memory groups, each local memory group including, a memory column including a plurality of memory cells, a pair of local bitlines operatively connected to the plurality of memory cells, and a local group periphery including a local bitline multiplexer operatively connected with the pairs of local bitlines of the corresponding local memory group; and a pair of global read bitlines operatively connected to outputs of the plurality of local group peripheries, a global read bitline multiplexer operatively connected to outputs of the plurality of pairs of the global read bitlines from the local memory group ways, and a bitline operational block operatively connected an output of the global read bitline multiplexer.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: December 28, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Marco Antonio Rios, William Andrew Simon, Alexandre Sébastien Levisse, Marina Zapater, David Atienza Alonso
  • Patent number: 11202911
    Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: December 21, 2021
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
  • Patent number: 11204375
    Abstract: A method for performing synchrophasor estimation of an input signal, whereby the input signal is a sinusoidal power system voltage or current signal, comprising: a. Periodic sampling of a continuous time-domain waveform, consisting of a power system voltage or current signal, to obtain a discrete time-domain function; b. Transforming a discrete time-domain function to a discrete frequency-domain function; c. Estimating from the discrete frequency-domain function the instantaneous parameters of a synchrophasor of the sampled continuous time-domain waveform, the instantaneous parameters comprising a frequency, an amplitude and a phase angle. The method is directed to an improvement of the enhanced IpDFT-based synchrophasor estimation which takes into account interharmonic tones.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 21, 2021
    Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
    Inventors: Asja Derviskadic, Paolo Romano, Mario Paolone