Abstract: The invention relates to an optoelectronic and/or photoelectrochemical device including a conductive support layer, n-type semiconductor, a sensitizer or light-absorber layer, a hole transporting layer, a spacer layer and a back contact, wherein the n-type semiconductor is in contact with the sensitizer or light-absorber layer, the sensitizer or light-absorber layer includes a perovskite or metal halide perovskite material, the hole transporting layer is in direct contact with the sensitizer or light-absorber layer and includes an inorganic hole transporting material or inorganic p-type semiconductor, the spacer layer is between the hole transporting layer and the back contact and includes a material being different from the inorganic hole transporting material and the material of the back contact.

Abstract: The present invention relates to engineered extra-cellular vesicle internalizing receptors that have the ability to enhance uptake, processing, and presentation to T-cells of tumor-associated antigens by an antigen-presenting cell. It further relates to vectors or antigen presenting cells expressing said receptors, composition and uses thereof for the prevention and/or treatment of a cancer.

Abstract: A device for aggregating cells includes a cavity. The cavity includes a plurality of microwells for receiving at least one cell. Each of the microwells includes a vertical sidewall and a curved bottom. The microwells are made in a hydrogel layer. Each of said microwells has a diameter and an interwell distance between one microwell and another microwell, wherein a ratio for the interwell distance to the diameter is less than or equal to 1/10.

Abstract: A method for manufacturing glass-based micro- and nanostructure comprising the step of dewetting a thin-film glass layer on a textured substrate to form the micro- and nanostructure from the thin-film glass layer.

Abstract: The composition for bone regeneration, comprises a) a first phase (3) comprising a plurality of cross-linked hydrogel chunks (1) having a mean diameter of less than 1000 ?m and incorporating an amount of mineral particles (2); and b) a second phase (4) comprising a physiologically-compatible aqueous liquid acting as a carrier for the chunks; the chunks being embedded in the second phase (4). The mineral particles (2) have a mean diameter of less than 10 ?m and the amount of the mineral particles (2) is less than 20 weight-% of the first phase.

Abstract: The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

Abstract: The present disclosure provides devices, systems, and methods for spinal cord stimulation. In some exemplary embodiments, a lead is provided. In one exemplary embodiment, the lead includes a paddle and an electrode array distributed in the paddle. The electrode array includes a first column of electrodes and a second column of electrodes. The first column of electrodes and the second column of electrodes are symmetric about the midline of the paddle. The first column of electrodes includes a first electrode, a second electrode, and a third electrode. The second column of electrodes includes a fourth electrode corresponding to the first electrode, a fifth electrode corresponding to the second electrode, and a sixth electrode corresponding to the third electrode. A vertical inter-electrode distance between the first electrode and the second electrode is larger than that between the second electrode and the third electrode.

Abstract: A data processing apparatus locates source cells responsible for an electrical anomaly in a subject's body part. The apparatus comprises means for: obtaining one or more electrical signals resulting from electrical activity of one or more source cells in the subject's body part; time-reversing the one or more electrical signals for obtaining one or more time-reversed electrical signals; feeding the one or more time-reversed electrical signals into a simulation model of the subject's body part, which is configured to model anatomy and/or electrical activity of the subject's body part, to cause the time-reversed electrical signals when fed into the simulation model to converge in the simulation model at one or more convergence locations; and identifying the one or more convergence locations in the simulation model thereby allowing locating the source cells responsible for the electrical anomaly.

Abstract: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (

Abstract: The present invention relates to a free-standing single crystalline diamond part and a single crystalline diamond part production method. The method includes the steps of: —providing a single crystalline diamond substrate or layer; —providing a first adhesion layer on the substrate or layer; —providing a second adhesion layer on the first adhesion layer: —providing a mask layer on the second adhesion layer; —forming at least one indentation or a plurality of indentations through the mask layer and the first and second adhesion layers to expose a portion or portions of the single crystalline diamond substrate or layer; and—etching the exposed portion or portions of the single crystalline diamond substrate or layer and etching entirely through the single crystalline diamond substrate or layer.

Abstract: A light pulse source and method for generating repetitive optical pulses are described. The light pulse source includes a continuous wave cw laser device, an optical waveguide optically coupled with the laser device, an optical microresonator, and a tuning device. The optical microresonator coupling cw laser light via the waveguide into the microresonator, which, may include, a light field in a soliton state with soliton shaped pulses coupled out of the microresonator for providing the repetitive optical pulses. The laser device includes a chip based semiconductor laser, the microresonator and/or the waveguide may reflect an optical feedback portion of light back to the semiconductor laser, which may provide self-injection locking relative to a resonance frequency of the microresonator. The tuning device is arranged for tuning at least one of a driving current and a temperature of the semiconductor laser such that the microresonator may provide the soliton state.

Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.

Abstract: Sensor system comprising a frame supporting a force-sensing tip arranged to generate a signal based upon a force applied by said force-sensing tip to a material to be tested, the system further comprising: an input drum mounted in said frame such that it can rotate about an input axis of rotation; an output lever supported by said frame by means of an output revolute joint defining an output axis of rotation; wherein said force-sensing tip is mounted on said output lever such that said force-sensing tip is arranged to be brought into contact with a material to be tested; and wherein said sensor system comprises a mechanical transmission arranged to kinematically link said input drum to said output lever such that a rotation of said input drum about said input axis of rotation causes said output lever to pivot in an oscillatory manner about said output axis of rotation.

Abstract: The invention discloses a system and method to obtain a set of corrected projected patterns from an integrated 3D measurement system so that the solidification of the formed object appears at the same time in a volumetric printer such as a tomographic back-projection or multi-beam printer, hence ensuring that the object is formed with the highest fidelity and spatial resolution.

Abstract: The present invention relates to a Semiconductor device including a first electrode, a second electrode and at least one semiconductor material or layer between the first and second electrode. The semiconductor device further includes at least one field plate structure for increasing a breakdown voltage of the semiconductor device. The at least one field plate structure comprises at least two recesses in the at least one semiconductor material or layer, the at least two recesses defining a semiconductor region therebetween, and a third electrode contacting or provided on the semiconductor region.

Abstract: The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention of primary cancer and/or cancer metastasis in a subject in need thereof.

Abstract: Data transformer apparatus comprising at least a dispatcher module (D), a reader module (R), a converter module (C) and a writer module (W). The dispatcher module (D) is configured to: receive a data transformation request (DTR) including: a first information item (X1) associated to a memory address where data to be transformed (Data1) are stored and to a type attribute (T) of said data to be transformed (Data1); a second information item (X2) indicating a memory address where transformed data (Data2), obtained from said data to be transformed (Data1), have to be written. The reader module (R) is configured to: retrieve the data to be transformed, according to said first information item (X1); obtain the type attribute (T) of the data to be transformed (Data1), based on said first information item (X1); send the data to be transformed (Data1) and the type attribute (T) thereof to the converter module (C).

Abstract: A biosensor includes a source element; a drain element; a semiconductor channel element between the source element and the drain element for forming an electrically conductive channel with adjustable conductivity between the source and drain elements; a first gate element configured to be electrically biased to set a given operational regime of the sensor with given electrical conductivity of the channel; and a second gate element, physically separate from the first gate element, configured to contact a solution comprising analytes allowed to interact with a gate contact surface of the second gate element to generate a surface potential change dependent on the concentration of the analytes in the solution. The channel element is substantially fully depleted allowing the first and second gate elements to be electrostatically coupled such that the surface potential change at the second gate element is configured to modify the electrical conductivity of the channel.

Abstract: The present relates to a carbon material having a 3D structure and made of graphene oxide and carbon nanotubes, characterized in that the 3D structure consists in that the carbon nanotubes are located with some agglomeration between the graphene oxide layers so as to extend the spacing between the graphene oxide layers.

Abstract: A fully wearable system used for communication and information transfer between two users or between a user and a machine to render an effective and intuitive physical interface for combined input and output functions, the fully wearable system including a bidirectional wearable skin including distributed actuator and sensing elements, the actuator and sensing elements including a multimodal actuation layer and a sensing layer, the bidirectional wearable skin being flexible and stretchable, and a portable control device for controlling the distributed actuator and sensing elements, and reading signals from the sensing layer, the portable control device is configured to perform pixilated actuation for both micro- and macrostimulation of a body of a wearer by an actuation frequency and stimulation amplitude.