Patents Assigned to Collagen Corporation
  • Patent number: 4582640
    Abstract: Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous medium at a concentration of 0.1 to 10 mg/ml with glutaraldehyde under conditions that produce cross-linked collagen that when in suspension in physiological saline at a concentration of 35 mg/ml exhibits a shear viscosity whose log varies linearly with the log of the shear rate and is approximated by the formulalog .eta..ltoreq.-0.96 log .gamma.+2.3where .gamma. is the shear rate in sec.sup.-1, log .gamma. is in the range of -6 to +2 and .eta. is the viscosity of the suspension in Pascal-sec; optionally quenching the cross-linking reaction with an amino acid; and separating the cross-linked atelopeptide collagen from the reaction mixture.
    Type: Grant
    Filed: October 22, 1984
    Date of Patent: April 15, 1986
    Assignee: Collagen Corporation
    Inventors: Thomas L. Smestad, John McPherson, Donald G. Wallace
  • Patent number: 4563350
    Abstract: A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when implanted in xenogeneic hosts.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: January 7, 1986
    Assignee: Collagen Corporation
    Inventors: Ranga Nathan, Saied Seyedin, Karl Piez, Hanne Bentz
  • Patent number: 4557764
    Abstract: A collagen preparation having unique properties of elasticity and malleability which is associated with a microscopic structure having an intertwining rope-like characteristic, and a process for preparing same are disclosed. The collagen thus formed is the second nucleation product obtained upon incubation of a supernatant from a quick harvested first stage nucleation product.
    Type: Grant
    Filed: September 5, 1984
    Date of Patent: December 10, 1985
    Assignee: Collagen Corporation
    Inventor: George Chu
  • Patent number: 4501306
    Abstract: An automatic syringe filling system includes a pump for supplying liquid under pressure to a manifold that distributes the liquid to each of a plurality of syringes. Microswitches disposed at predetermined positions detect when the plunger of each syringe connected to the manifold has been extended a particular distance determined by the desired fill volume. When all of the plungers are extended this distance, the supply of liquid to the manifold is discontinued by closing a valve and deactuating the pump.
    Type: Grant
    Filed: November 9, 1982
    Date of Patent: February 26, 1985
    Assignee: Collagen Corporation
    Inventors: George Chu, Sharon Casella
  • Patent number: 4481001
    Abstract: A skin model for use in demonstrating or practicing intradermal injection of fluids is disclosed. The model is a composite laminate of: (1) a subcutaneous tissue-simulating layer made of a foamed elastomer of low compression deflection and hardness; (2) a dermis-simulating layer of about 1 to 3 mm thick of that is substantially nonporous has a slightly greater hardness than the subcutaneous tissue-simulating layer and a penetration value in the range of 30 to 100 mm and is made of a silicone elastomer that contains reinforcing fibers, and, optionally, flesh tone pigment; and (3) in epidermis-simulating layer about 0.1 to 1 mm thick made of a high tear strength, high tensile strength elastomer. One or more of the layers may be contoured so that the surface of the model is shaped to simulate contour defects in natural skin.
    Type: Grant
    Filed: May 26, 1983
    Date of Patent: November 6, 1984
    Assignee: Collagen Corporation
    Inventors: Thomas E. Graham, Eric E. Sabelman
  • Patent number: 4465478
    Abstract: A syringe assist device including a frame and moveable carriage that are respectively attached to a conventional syringe and its plunger. The frame has a toothed rack and the carriage contains a force amplifying gear and lever mechanism. A thumb ring transmits the force applied by the user's thumb to the lever to rotate the gear and move the carriage along the frame. This action in turn applies amplified compression to the syringe plunger. A ratchet connection between the lever and the gear enables the movement of the carriage to be continued without force amplification when the lever has reached the end of its stroke.
    Type: Grant
    Filed: October 14, 1982
    Date of Patent: August 14, 1984
    Assignee: Collagen Corporation
    Inventors: Eric E. Sabelman, Timothy A. Koogle, William Kennedy
  • Patent number: 4440750
    Abstract: A plastic dispersion of demineralized bone powder and reconstituted native atelopeptide collagen fibers in a continuous aqueous phase having a substantially physiologic pH and ionic strength is used to repair or construct bone by injecting or implanting it at the repair or construction site. Once emplaced the dispersion induces rapid and complete osteogenesis at the site.
    Type: Grant
    Filed: February 12, 1982
    Date of Patent: April 3, 1984
    Assignees: Collagen Corporation, President and Fellows of Harvard College
    Inventors: Julianne Glowacki, Bruce B. Pharriss
  • Patent number: 4434094
    Abstract: A process for partially purifying an osteogenic factor from demineralized bone particles in which nonfibrous proteins are extracted from the demineralized bone with a dissociative extractant for nonfibrous proteins, such as urea or guanidine hydrochloride, the extracted nonfibrous proteins are fractionated by anion exchange chromatography using DEAE cellulose at pH 7, the fraction not adsorbed by the DEAE cellulose is further fractionated by cation exchange chromatography using CM cellulose at pH 4.8, the fraction adsorbed by the CM cellulose is eluted therefrom and the partially purified osteogenic factor is recovered from the eluate as a .ltoreq.30,000 dalton protein isolate.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: February 28, 1984
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas
  • Patent number: 4430760
    Abstract: A flexible, nonstress-bearing bone prosthesis is disclosed that comprises demineralized bone powder contained within a medical grade porous flexible casing made from polymeric fibers or a micro-porous membrane. The pores of the casing are smaller than the particle size of the bone powder but large enough to permit ingress of body cells associated with bone formation.
    Type: Grant
    Filed: December 18, 1981
    Date of Patent: February 14, 1984
    Assignee: Collagen Corporation
    Inventor: Thomas L. Smestad
  • Patent number: 4424208
    Abstract: An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this material have improved persistence relative to currently used collagen implant materials.
    Type: Grant
    Filed: January 11, 1982
    Date of Patent: January 3, 1984
    Assignee: Collagen Corporation
    Inventors: Donald G. Wallace, Susan B. Wade
  • Patent number: 4288498
    Abstract: Chrome tanned leather scrap is converted into thermal insulation by shredding the tanned leather scrap into leather fibers, without damaging the structural fiber integrity, and case hardening the shredded leather fibers. The shredded leather fibers are case hardened by reducing the moisture content thereof to less than 5% by weight, and preferably less than 2%.
    Type: Grant
    Filed: May 6, 1980
    Date of Patent: September 8, 1981
    Assignee: Collagen Corporation
    Inventor: Herbert C. Scribner, Jr.
  • Patent number: 4250139
    Abstract: Method for decontaminating proteinaceous host materials from microorganisms, while retaining chemical, physical and physiological properties of said host proteinaceous materials, said method comprising substantially dehydrating said host proteinaceous material, preferably by lyophilization, and subjecting said host material to a lethal dosage of microwave energy while said host material is maintained in substantially ambient conditions.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: February 10, 1981
    Assignee: Collagen Corporation
    Inventors: Edward E. Luck, John R. Daniels
  • Patent number: 4233360
    Abstract: Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM).
    Type: Grant
    Filed: September 25, 1978
    Date of Patent: November 11, 1980
    Assignee: Collagen Corporation
    Inventors: Edward E. Luck, John R. Daniels
  • Patent number: 4140537
    Abstract: The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers.
    Type: Grant
    Filed: November 24, 1976
    Date of Patent: February 20, 1979
    Assignee: Collagen Corporation
    Inventors: Edward E. Luck, John R. Daniels